Asphyxia and Its Classifications
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Questions and Answers

What effect can long-term corticosteroid use have on children?

  • Enhance growth and development
  • Stabilize hormonal levels
  • Promote cognitive advancement
  • Interfere with growth and development (correct)

Which stage of adolescence occurs between the ages of 15 and 17 years?

  • Middle adolescence (correct)
  • Pre-adolescence
  • Late adolescence
  • Early adolescence

According to Erikson's theory, what consequence does failing to achieve a sense of industry in childhood lead to?

  • Developing a sense of independence
  • Developing a sense of inferiority (correct)
  • Establishing a strong identity
  • Achieving better cognitive skills

What is a common cognitive change associated with aging?

<p>Decline in short-term memory (A)</p> Signup and view all the answers

What characterizes the formal operational stage in Jean Piaget's theory?

<p>Ability to think abstractly and reason logically (D)</p> Signup and view all the answers

What characterizes primary apnea in a newborn?

<p>Transient rapid breathing followed by cessation. (A)</p> Signup and view all the answers

Which of the following are identified risk factors for birth asphyxia during labor?

<p>Prolonged or obstructed labor. (B)</p> Signup and view all the answers

What is a primary consequence of asphyxia?

<p>Hypoxic Ischaemic Encephalopathy. (B)</p> Signup and view all the answers

Which intervention helps to minimize fetal heart deceleration during labor?

<p>Maternal positioning to left lateral. (C)</p> Signup and view all the answers

What immediate action is included in the resuscitation protocol for a newborn?

<p>Routine gastric aspiration. (A)</p> Signup and view all the answers

What is a significant physiologic change during chronic fetal hypoxia?

<p>Development of placental insufficiency. (B)</p> Signup and view all the answers

During uterine contractions, what happens to blood flow to the fetus?

<p>It is momentarily interrupted. (A)</p> Signup and view all the answers

What is the primary method to assess the newborn's condition at 30 seconds of life?

<p>Checking for heart rate &lt; 100 bpm. (B)</p> Signup and view all the answers

What is the predominant hemoglobin type found in adults?

<p>Hb A (α2β2) (C)</p> Signup and view all the answers

Which variant of hemoglobin is associated with sickle cell disease?

<p>Hb S (α2βS2) (D)</p> Signup and view all the answers

What does an Apgar score of 3 or lower at 5 minutes indicate?

<p>Poor correlation with adverse future neurological outcomes (A)</p> Signup and view all the answers

What type of red blood cell variation is caused by iron-deficiency anemia?

<p>Microcytes (A)</p> Signup and view all the answers

What is the primary cause of Respiratory Distress Syndrome (RDS) in preterm infants?

<p>Deficiency of surfactant (C)</p> Signup and view all the answers

Which stage of labor involves the most rapid cervical dilation?

<p>First stage - Dilatational division (C)</p> Signup and view all the answers

At what gestational age should corticosteroids be administered to mothers at risk of preterm delivery to aid fetal lung maturity?

<p>Before 32–34 weeks gestation (C)</p> Signup and view all the answers

Which condition is characterized by β-chain abnormalities and can lead to mild hemolytic anemia?

<p>Hemoglobin C (C)</p> Signup and view all the answers

What could potentially cause delayed physical milestones such as walking?

<p>Growth Hormone Deficiency (B)</p> Signup and view all the answers

What physiological change indicates adequate ventilation in a neonate?

<p>Improved heart rate (A)</p> Signup and view all the answers

Which type of leukocytosis is characterized by an increase in neutrophils?

<p>Neutrophilia (D)</p> Signup and view all the answers

In the context of hemopoiesis, which stage occurs during the first two months of intrauterine life?

<p>Mesoblastic stage (D)</p> Signup and view all the answers

What type of red blood cell variation is typically seen in megaloblastic anemia?

<p>Macrocytes (C)</p> Signup and view all the answers

What is the main organ responsible for producing red blood cells during the hepatic stage of hemopoiesis?

<p>Liver (C)</p> Signup and view all the answers

What component is the iron-containing pigment in hemoglobin?

<p>Heme (D)</p> Signup and view all the answers

After the age of 20 years, which bones primarily contribute to the production of red blood cells?

<p>Flat bones such as the pelvis and skull (D)</p> Signup and view all the answers

Flashcards

What is Asphyxia?

The term 'asphyxia' refers to a condition where breathing is impaired, leading to a shortage of oxygen (hypoxia) and an excess of carbon dioxide (hypercapnia) in the body. This ultimately results in metabolic acidosis, a state where the body's fluids become too acidic.

What is Birth Asphyxia?

Birth asphyxia occurs when a newborn fails to initiate and maintain breathing immediately after birth, which can lead to lasting harm or even death.

What are the consequences of Birth Asphyxia?

Hypoxic Ischemic Encephalopathy (HIE) is a brain injury that happens when the brain doesn't get enough oxygen during birth. It can lead to long-term disabilities.

What are the classifications of Asphyxia?

Acute asphyxia occurs suddenly due to factors during labor and delivery, while chronic asphyxia happens slowly due to prolonged lack of oxygen before birth.

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What is Intrapartum Resuscitation?

Intrapartum resuscitation focuses on providing support to the mother and fetus during labor to prevent or manage birth asphyxia.

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What are the causes of Acute Fetal Hypoxia?

Maternal hypotension, placental abruption, and cord prolapse can all lead to acute asphyxia due to sudden interruptions in oxygen supply to the fetus.

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What are the causes of Chronic Fetal Hypoxia?

Maternal respiratory disease, placental infections, and fetal infections can contribute to chronic asphyxia due to long-term oxygen deprivation.

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What are the management steps for a newborn with birth asphyxia?

Positive pressure ventilation with room air should be administered to a newborn if they exhibit apnea, gasping respirations, or a heart rate less than 100 bpm after 30 seconds of delivery.

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Surfactant

A complex mix of phospholipids and proteins that are secreted by type II pneumocytes, which helps decrease surface tension in the lung's alveoli.

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Respiratory Distress Syndrome (RDS)

A respiratory condition commonly observed in premature infants, characterized by a deficiency in surfactant, leading to difficulty in breathing and labored breathing.

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Tachypnea

Rapid and shallow breathing.

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Hematopoiesis (Hemopoiesis)

The process by which blood cells are formed, developed, and matured within the body.

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Heme

The pigment part of hemoglobin, containing iron.

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Ferrous (Fe2+)

The iron within hemoglobin.

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Globin

The protein part of hemoglobin.

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Oxygen Saturation

A measure of the percentage of oxygen bound to hemoglobin in the blood.

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What is Hypoxic Ischemic Encephalopathy (HIE)?

A brain injury resulting from the brain not receiving enough oxygen during birth, potentially leading to long-term disabilities.

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What is Acute Asphyxia?

Occurs suddenly due to factors during labor and delivery, interrupting oxygen supply to the fetus.

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What is Chronic Asphyxia?

Happens gradually due to prolonged lack of oxygen before birth, often caused by underlying health conditions.

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Intrapartum Resuscitation

Providing support to the mother and fetus during labor to prevent or manage birth asphyxia.

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Growth Spurt During Adolescence

A rapid increase in height and weight, typically starting earlier in girls (around 10-12 years) than boys (around 12-14 years).

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Formal Operational Stage

The stage of cognitive development in adolescence according to Piaget's theory, where individuals gain the ability to think abstractly, logically, and hypothetically.

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Identity vs. Role Confusion

Erikson's theory suggests adolescence is the stage where individuals strive to develop a sense of self and identity, exploring different roles and values.

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Gerontology

The scientific study of the aging process and its effects on individuals, including physical, cognitive, and social aspects.

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Geriatrics

The medical specialty that focuses on the healthcare and well-being of older adults. It involves the diagnosis, treatment, and management of age-related health conditions.

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Study Notes

Asphyxia

  • Impaired respiratory gas exchange (hypoxia and hypercapnia), accompanied by metabolic acidosis
  • Birth asphyxia: failure to initiate and sustain breathing at birth
  • Consequences/etiology/causes of asphyxia: hypoxic-ischemic encephalopathy, organ failure, and neonatal death

Classifications of Asphyxia

  • Acute: caused by intranatal factors only
  • Chronic: background of prolonged fetal hypoxia and placental insufficiency

Intranatal Risk Factors for Birth Asphyxia

  • Fetal arterial blood oxygen tension: 25 ± 5 mm Hg
  • Oxygen consumption is twice that of the adult per unit weight
  • Fetal oxygen reserve: 1-2 minutes
  • Uterine contractions: momentarily interrupt blood flow
  • Cord compression: during contractions
  • Failure to progress/dystocia: prolonged or obstructed labor exhausts the fetus

Causes of Fetal Hypoxia

  • Acute:
    • Maternal hypotension
    • Placental abruption
    • Cord prolapse
    • Maternal infection
    • Maternal respiratory disease
  • Chronic:
    • Any maternal infection
    • Maternal respiratory disease

Intrapartum Resuscitation

  • Maternal positioning to left lateral: reduces fetal heart deceleration risk
  • Stopping contractions (tocolytics or uterine relaxation): restores maternal blood flow to placenta
  • Intravenous fluids: corrects maternal hypovolemia and hypotension
  • Oxygen

Primary Apnea

  • Transient period of rapid breathing with oxygen deprivation
  • If prolonged, breathing stops (primary apnea)
  • Further oxygen deprivation leads to gasping respirations, then secondary apnea
  • Decline in heart rate and blood pressure, and loss of neuromuscular tone

Management of Fetal Distress (Resuscitation Protocol)

  • Basic measures:
    • Warm the newborn to minimize heat loss
    • Clear the airway
    • Dry the infant
    • Routine gastric aspiration
  • Assessment at 30 seconds of life:
    • Apnea, gasping respirations, or heart rate < 100 bpm beyond 30 seconds after delivery: perform positive-pressure ventilation with room air
    • Monitor oxygen saturation with pulse oximetry

Additional Information (Page 2)

  • Assessment at 60 seconds of life:
    • Persistent heart rate below 100 bpm beyond 60 seconds warrants tracheal intubation and head position correction
    • Clear secretions and increase inflation pressure
  • Clinical findings in fetal distress:
    • Acidaemia (pH < 7 in umbilical artery blood sample)
    • Apgar score of 0-3 persisting 10 minutes or longer
  • Apgar Score: Used to identify neonates needing resuscitation and evaluate resuscitative measures
    • 7+ at 1 minute: Normal
    • 9-10 at 5 minutes: Normal
    • 5-minute Apgar score of 3 correlates poorly with adverse neurological outcomes
  • Respiratory distress syndrome (RDS): Hyline membrane disease in preterm infants due to surfactant deficiency, reducing alveolar surface tension
  • Corticosteroids: Given to mothers at risk of delivery before 32-34 weeks to hasten fetal organ maturation

Hemopoiesis (Haematopoiesis)

  • Process of origin, development, and maturation of all blood cells
  • Sites of hematopoiesis:
    • Mesoblastic (first two months of intrauterine life, yolk sac)
    • Hepatic (third month, liver)
    • Myeloid (last three months, red bone marrow, and liver; exclusively from red bone marrow after birth in newborns, children, and adults)(except from flat bones to 20 years and bones ends of long bones after 20 years old)

Hemoglobin Variations

  • Abnormal hemoglobin variations that result in diseases like:
    • Sickle cell disease (Hb S)
    • Mild chronic hemolytic anemia (Hb C)

Leukocytes Variation

  • Pathological leukocytosis occurs when one type of leukocyte increases at the expense of others,
  • Possible causes include infections (e.g., neutrophilia, eosinophilia, basophilia, lymphocytosis, monocytosis) or allergic conditions

Labor Stages

  • First Stage: Preparatory and dilatational divisions, cervix dilation
  • Second Stage: Fetal delivery
  • Third Stage: Placental delivery
  • Pelvic Division: Deceleration and final phase of cervical dilatation

Other Information (Page 4)

  • Causes of growth failure and delayed milestones:
    • Genetic and chromosomal conditions
    • Nutritional deficiencies
    • Hormonal imbalances (growth hormone deficiency and corticosteroid use)
    • Thyroid disorders
  • Eriksson's Theory: Child development sense of industry and inferiority
  • Adolescence: transition from childhood to adulthood (early, middle, late)
  • Physical Growth: Growth spurt in adolescence (earlier in girls than boys)
  • Jean Piaget's Cognitive Development Theory: formal operational stage in adolescence
  • Erik Erikson's Psychosocial Development Theory: Identity vs. role confusion in adolescence
  • Aging: Biological process of growing older; gerontology; geriatrics (health care of older adults)
  • Common diseases of old age: cardiovascular, arthritis, osteoporosis, cognitive changes

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Description

This quiz explores the critical concepts surrounding asphyxia, including its definitions, classifications, and the intranatal risk factors that contribute to birth asphyxia. Delve into the causes of fetal hypoxia and understand the implications of impaired respiratory gas exchange. Test your knowledge on this vital subject in neonatal health.

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