Ascorbate Biosynthesis in Animals and Plants
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Questions and Answers

What is the defining characteristic of an essential vitamin?

  • It can be synthesized by the human body
  • It acts as an antioxidant
  • It is involved in catalysis
  • It is only made by microbes (correct)
  • Which type of molecules function as carriers of specific functional groups and participate in catalysis but are not permanently bound to the enzyme?

  • Metal ions
  • Coenzymes (correct)
  • Vitamins E and C
  • Cofactors
  • What is the role of iron as a cofactor in enzymes?

  • Involved in redox reactions and oxygen-binding (correct)
  • Acts as an antioxidant
  • Participates in photosynthesis
  • Essential for biosynthesis of plant hormones
  • Why do some fruits have high concentrations of ascorbic acid?

    <p>Acts as an antioxidant</p> Signup and view all the answers

    In animals, how is ascorbate biosynthesis different from plants?

    <p>It is made from UDP-D-glucose</p> Signup and view all the answers

    Which vitamins are considered redox vitamins?

    <p>Vitamin E and C</p> Signup and view all the answers

    What is the last step in the biosynthesis of ascorbic acid (vitamin C)?

    <p>L-Galactono-1,4-lactone is dehydrated into L-ascorbic acid</p> Signup and view all the answers

    Why does herbivory reduce the evolutionary pressure to maintain ascorbate biosynthesis in plants?

    <p>Herbivores eat a lot of plants anyway.</p> Signup and view all the answers

    What is the role of vitamin C in collagen synthesis?

    <p>It acts as a cofactor for the enzyme that catalyzes hydroxylation of amino acid residues in the collagen protein chains.</p> Signup and view all the answers

    What is the cause of scurvy?

    <p>The inability to convert proline to hydroxyproline.</p> Signup and view all the answers

    Why do some animals always lose the ability to produce vitamin C in their bodies?

    <p>The loss always occurs in the GLO gene.</p> Signup and view all the answers

    What is the main structural feature of collagen?

    <p>Triple helix of similar peptide chains</p> Signup and view all the answers

    What role does acetic acid play when there's not enough oxygen?

    <p>Causes burns of muscles by acidification.</p> Signup and view all the answers

    Why do we evolve antioxidants in response to radical formation?

    <p>To counteract the effects of lipid membrane reactions caused by oxygen free radicals.</p> Signup and view all the answers

    What process does vitamin C assist in for collagen synthesis?

    <p>Hydroxylation</p> Signup and view all the answers

    What is the role of ascorbic acid (vitamin C) during times when there is not enough oxygen?

    <p>Acts as a terminal oxygen acceptor</p> Signup and view all the answers

    Why did the loss of vitamin C biosynthesis occur?

    <p>Herbivory reduces evolutionary pressure to maintain ascorbate biosynthesis, since herbivores eat a lot of plants anyway.</p> Signup and view all the answers

    Why is the loss of vitamin C biosynthesis always in the GLO gene?

    <p>To minimize the number of metabolic intermediates disrupted; mutations in upstream genes may not be tolerated.</p> Signup and view all the answers

    Why is the last step in the biosynthesis of ascorbic acid (vitamin C) similar in animals and plants?

    <p>The last step is similar to animal biosynthesis of vitamin C.</p> Signup and view all the answers

    What is the defining characteristic of an essential vitamin?

    <p>Essential vitamins must be obtained from the diet, as the body cannot produce them in sufficient quantities.</p> Signup and view all the answers

    What is the role of ascorbic acid (vitamin C) in collagen synthesis?

    <p>Vitamin C assists in the hydroxylation of proline and lysine residues in collagen synthesis.</p> Signup and view all the answers

    What process does vitamin C assist in for collagen synthesis?

    <p>Vitamin C assists in the hydroxylation of proline and lysine residues in collagen synthesis.</p> Signup and view all the answers

    What is the quaternary structure of collagen?

    <p>Triple helix of similar peptide chains</p> Signup and view all the answers

    What is the consequence of vitamin C deficiency in terms of collagen synthesis?

    <p>Inefficient collagen synthesis, possibly leading to conditions like scurvy</p> Signup and view all the answers

    What is the role of iron ions in collagen synthesis?

    <p>Cofactors for the enzyme lysyl hydroxylase involved in hydroxylation of lysine residue</p> Signup and view all the answers

    What is the function of flavonoids in the body?

    <p>Act as antioxidants and require oxoacid dependent dioxygenase (ODDO) for their synthesis</p> Signup and view all the answers

    How does ascorbate function in terms of electron transfers?

    <p>It can donate one or two electrons and be oxidized twice, producing dehydroascorbate</p> Signup and view all the answers

    What is the role of vitamin E in radical formation?

    <p>It can donate a single electron and become a radical</p> Signup and view all the answers

    What is the process that results in the acidification of muscles when there is not enough oxygen?

    <p>Conversion of pyruvate to lactate</p> Signup and view all the answers

    What is the role of hydroxyl free radicals in the body?

    <p>They can react with lipid membranes, leading to the need for antioxidants</p> Signup and view all the answers

    What is the consequence of a lack of vitamin C in terms of collagen hydroxylation?

    <p>Inefficient hydroxylation of proline and lysine amino acid residues in collagen protein chains</p> Signup and view all the answers

    What is the relationship between vitamin C and the enzyme prolyl 4-hydroxylase in collagen synthesis?

    <p>Vitamin C is involved as a cofactor for the enzyme prolyl 4-hydroxylase that catalyzes the hydroxylation reactions</p> Signup and view all the answers

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