Arterial Blood Pressure and Regulation
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Questions and Answers

Which mechanism involves the vesicular transport of macromolecules across a cell?

  • Hydrostatic transport
  • Diffusion
  • Transcytosis (correct)
  • Filtration
  • What primarily determines the movement of water across capillary membranes?

  • Starling equilibrium (correct)
  • Venous pressure
  • Osmotic pressure only
  • Capillary blood flow rate
  • Which substance diffuses from capillaries into tissues?

  • Lipids
  • Na+
  • Cl-
  • CO2 (correct)
  • How much of the total blood volume is typically contained in veins?

    <p>64%</p> Signup and view all the answers

    What condition causes water to move from the interstitium into the capillary?

    <p>Plasma oncotic pressure higher than hydrostatic pressure</p> Signup and view all the answers

    What is the formula for calculating Mean Arterial Pressure (MAP)?

    <p>MAP = DBP + 1/3 pulse pressure</p> Signup and view all the answers

    Which type of artery is characterized by high compliance and low resistance?

    <p>Elastic arteries</p> Signup and view all the answers

    What primarily regulates blood flow through arterioles?

    <p>Smooth muscle contraction and relaxation</p> Signup and view all the answers

    In a blood pressure reading of 120/80 mmHg, what is the systolic blood pressure (SBP)?

    <p>120 mmHg</p> Signup and view all the answers

    Which of the following statements about pulse pressure (PP) is correct?

    <p>PP is the difference between systolic and diastolic pressure.</p> Signup and view all the answers

    What is the main function of the peripheral arterial system?

    <p>Hemoperfusion</p> Signup and view all the answers

    Which of the following arteries is directly associated with blood pressure measurement?

    <p>Brachial artery</p> Signup and view all the answers

    Which component primarily controls the cardiac output regulation?

    <p>Heart rate and stroke volume</p> Signup and view all the answers

    What does pulse pressure (PP) depend on?

    <p>Stroke volume and aortic compliance</p> Signup and view all the answers

    What is the relationship between venous return and cardiac output according to the Frank-Starling principle?

    <p>Cardiac output equals venous return</p> Signup and view all the answers

    What happens to stroke volume as heart rate increases significantly?

    <p>Stroke volume decreases due to shorter diastole</p> Signup and view all the answers

    What does the Mean Arterial Pressure (MAP) depend on?

    <p>Cardiac output and total peripheral resistance</p> Signup and view all the answers

    What physiological factor influences cardiac output through preload?

    <p>Stretch of cardiac muscle</p> Signup and view all the answers

    Which of the following causes an increase in venous return?

    <p>Venous compression or constriction</p> Signup and view all the answers

    At what heart rate does the increase in heart rate notably affect cardiac output?

    <p>Between 60 and 100 beats per minute</p> Signup and view all the answers

    Which of these statements about stroke volume (SV) is correct?

    <p>SV decreases when heart rate increases due to decreased diastole</p> Signup and view all the answers

    What effect does parasympathetic stimulation have on heart rate?

    <p>Decreases heart rate</p> Signup and view all the answers

    Which type of receptor is implicated in sympathetic nerve activity affecting heart contractility?

    <p>b receptor</p> Signup and view all the answers

    What is the impact of sympathetic stimulation on conduction velocity?

    <p>Increases conduction velocity</p> Signup and view all the answers

    Which term refers to the effect of autonomic regulation on heart rate?

    <p>Chronotropy</p> Signup and view all the answers

    What happens to pacemaker activity during parasympathetic stimulation?

    <p>Decreases pacemaker activity</p> Signup and view all the answers

    What kind of dromotropism is associated with parasympathetic stimulation?

    <p>Negative dromotropism</p> Signup and view all the answers

    During which state does the parasympathetic system predominantly operate?

    <p>Rest</p> Signup and view all the answers

    Which effect is primarily produced by sympathetic stimulation in relation to heart contractility?

    <p>Increased contractility</p> Signup and view all the answers

    What is the pressure difference between the venule and the right atrium?

    <p>10 mmHg</p> Signup and view all the answers

    Which factor does NOT promote venous return?

    <p>High resistance in veins</p> Signup and view all the answers

    What happens to venous return when a person stands up suddenly?

    <p>Venous return decreases</p> Signup and view all the answers

    Which structure is responsible for preventing backflow of blood in veins?

    <p>Venous valves</p> Signup and view all the answers

    What role does the diaphragm play in venous return during respiration?

    <p>Promotes vein expansion</p> Signup and view all the answers

    Which artery supplies blood to the left ventricle?

    <p>Left coronary artery</p> Signup and view all the answers

    The coronary sinus drains blood into which part of the heart?

    <p>Right atrium</p> Signup and view all the answers

    Which of the following statements about coronary circulation is true?

    <p>It involves a capillary network</p> Signup and view all the answers

    Study Notes

    Arterial Blood Pressure

    • Mean Arterial Pressure (MAP): Average blood pressure during the cardiac cycle, represents the main driving force for blood flow.
    • Arterial Pulse Pressure (PP): Difference between systolic and diastolic pressure, determined by stroke volume and aortic compliance
    • Peripheral Arterial Pressure Curves: Shows variations in arterial pressure throughout the body's circulatory system.

    Blood Pressure Measurement

    • Measured using a sphygmomanometer and stethoscope.
    • Measured in the brachial artery.
    • Sounds heard during measurement are called Korotkoff's sounds.

    Control of Blood Pressure

    • Determinants of Arterial Pressure: Determined by cardiac output and total peripheral resistance (TPR)
    • Total Peripheral Resistance (TPR): Represents the resistance to blood flow in all the peripheral vessels combined.

    Regulation of Cardiac Output

    • Frank-Starling Principle: Cardiac output is dependent on preload (the amount of stretch in the ventricle), which is determined by venous return.
    • Venous Return (VR): Flow of blood back to the heart.
    • Increase in venous return: Due to increased total blood volume or redistribution of blood via venous compression/constriction
    • Cardiac Output (CO): Amount of blood ejected from the heart per minute.

    Regulation by Baroreceptor and Cardioregulatory Center

    • Baroreceptors: Sensory receptors located in the aortic arch and carotid arteries, sensitive to changes in blood pressure.
    • Cardioregulatory Center: Located in the brainstem, responsible for regulating heart rate, stroke volume, and vascular tone.
    • Sympathetic Nervous System: Increases heart rate, contractility, and conduction velocity.
    • Parasympathetic Nervous System: Decreases heart rate, contractility, and conduction velocity.

    Arterial System & Function

    • Elastic arteries: High in compliance, low in resistance, act as a pressure storage vessel and help to reduce heart work.
    • Arteries: Relatively large diameter compared to vessel wall thickness, contribute to low resistance and a small pressure drop.
    • Arterioles: Small internal diameter, high resistance, considered "resistance vessels" as they cause a significant pressure drop.
    • Arterioles: Control blood flow by constricting and relaxing smooth muscle within their walls which increases/decreases resistance, regulating blood flow.

    Control of Blood Pressure: Physical & Physiological Factors

    • Physical Factors: Influence pulse pressure (PP)
      • PP is proportional to stroke volume (SV) divided by aortic compliance (C)
    • Physiological Factors: Influence mean arterial pressure (MAP)
      • MAP is equal to cardiac output (CO) multiplied by total peripheral resistance (TPR)

    Effect of Heart Rate on Cardiac Output

    • Relationship: Cardiac output (CO) is calculated by multiplying stroke volume (SV) and heart rate (HR).
    • Stroke Volume: Decreases as heart rate increases due to shortened diastole, reduced ventricular filling, and decreased preload.
    • Cardiac Output Changes with Heart Rate:
      • HR increase up to 100: CO increases as the HR-increase effect outweighs SV-decrease effect due to increased contractility.
      • HR between 100-200: No significant change in CO.
      • HR over 200: CO decreases as SV-decrease effect outweighs the HR-effect.

    Autonomic Regulation of the Heart

    • Sympathetic innervation: To both atria and ventricles.
    • Parasympathetic innervation: To the SA and AV nodes, as well as the atria.
    • Parasympathetic effects: Decreases heart rate, contractility, and conduction velocity via M receptors.
    • Sympathetic effects: Increases heart rate, contractility, and conduction velocity via b receptors.

    Effects on SA Node

    • Dromotropism: Changes in conduction velocity influenced by sympathetic and parasympathetic stimulation.
    • Sympathetic stimulation: Positive dromotropism (increased conduction velocity) via NE.
    • Parasympathetic stimulation: Negative dromotropism (decreased conduction velocity) via ACh.
    • Dominant effect: Parasympathetic outweighs sympathetic on the SA node.

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    Description

    This quiz covers the critical concepts and measurements related to arterial blood pressure, including Mean Arterial Pressure, Pulse Pressure, and methods of measurement. Additionally, it explores the determinants and regulation of cardiac output, emphasizing the Frank-Starling Principle. Test your knowledge on these fundamental cardiovascular principles!

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