Are You an AIDS Expert?

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Questions and Answers

What are the two classes of immuno-deficiency states?

Congenital and acquired

Primary and secondary (correct)

Inherited and acquired

Acute and chronic

Which type of immuno-deficiency state is more common?

It depends on the age of the patient

Secondary (correct)

Primary

Both are equally common

What is the cause of AIDS?

A viral disease caused by HIV (correct)

A genetic disorder

A fungal infection

A bacterial infection

What is AIDS?

A retroviral disease caused by HIV Signup and view all the answers

What are the major routes of HIV transmission?

Sexual contact, parenteral inoculation, and vertical transmission Signup and view all the answers

What is the most common route of HIV transmission?

Sexual contact Signup and view all the answers

What are the groups at risk of developing AIDS?

Homosexual or bisexual males, intravenous drug abusers, heterosexual contacts with multiple sexual partners, and recipients of blood contaminated with HIV (e.g., hemophiliacs) Signup and view all the answers

Which groups are at risk of developing AIDS?

Homosexual or bisexual males, intravenous drug abusers, heterosexual contacts with multiple sexual partners, and recipients of blood contaminated with HIV Signup and view all the answers

What is the CD4 molecule's role in HIV infection?

It is a high-affinity receptor for HIV that the virus uses to gain entry to T-lymphocytes Signup and view all the answers

What is the major receptor for HIV?

CD4 molecule Signup and view all the answers

What are the clinical phases of HIV infection?

Acute retroviral syndrome, chronic phase, and crisis phase Signup and view all the answers

What are the clinical phases of HIV infection?

Acute retroviral syndrome, chronic phase, and crisis phase Signup and view all the answers

What are some examples of opportunistic infections that patients with AIDS may develop?

Pneumocystis carinii pneumonia, recurrent mucosal candidiasis, disseminated cytomegalovirus infection, herpes simplex, Mycobacterium tuberculosis, atypical mycobacteria, toxoplasmosis, cryptococcal meningitis, and Cryptosporidium or isospora belli infections causing persistent diarrhea Signup and view all the answers

What are some of the opportunistic infections commonly seen in AIDS patients?

What is AIDS-dementia complex?

A progressive encephalopathy clinically called AIDS-dementia complex Signup and view all the answers

What is AIDS-dementia complex?

A progressive encephalopathy Signup and view all the answers

What is the worldwide prevalence of HIV infection?

Over 35 million people Signup and view all the answers

What is the most effective defense in the fight against AIDS?

Prevention and effective public health measures Signup and view all the answers

What is the percentage of patients with clinically evident neurologic dysfunction?

40%-60% Signup and view all the answers

What are the two main types of HIV?

HIV-1 and HIV-2 Signup and view all the answers

What is the origin of HIV?

Western Africa Signup and view all the answers

Why is vaccine development for AIDS difficult?

Due to a huge degree of polymorphism in viral isolates from different AIDS patients Signup and view all the answers

Is HIV infection transmitted by usual personal contact?

No Signup and view all the answers

Why is vaccine development for AIDS difficult?

Because of a huge degree of polymorphism in viral isolates from different AIDS patients Signup and view all the answers

Study Notes

Overview of Immuno-Deficiency States and AIDS

There are two classes of immuno-deficiency states: primary (present at birth, usually due to a genetic disorder) and secondary (much more common and can be caused by various factors, such as old age, chronic malnutrition, widespread malignancy, diseases, drug therapy, and AIDS).
Examples of primary immunodeficiency states include X-linked agammaglobulinemia, isolated IgA-deficiency, severe combined immune deficiency, and acquired immunodeficiency syndrome (AIDS).
AIDS is a retroviral disease caused by human immunodeficiency virus (HIV) and is characterized by severe immune suppression leading to opportunistic infections, secondary neoplasms, and neurological manifestations.
Worldwide, over 35 million people are infected with HIV, most of them in Africa. The virus has originated in Western Africa, and there are two main types of HIV, HIV-1 and HIV-2.
The major routes of HIV transmission are sexual contact, parenteral inoculation (e.g., dirty needles), and vertical transmission (from infected mothers to their newborns).
Groups at risk of developing AIDS include homosexual or bisexual males, intravenous drug abusers, heterosexual contacts with multiple sexual partners, and recipients of blood contaminated with HIV (e.g., hemophiliacs).
HIV infection is not transmitted by usual personal contact like shaking hands or hugging, and there is no convincing evidence for spread by insect bites.
The pathogenesis of HIV disease involves the immune system and the central nervous system (CNS). The virus gains entry to T-lymphocytes by attaching to surface CD4 molecules, and the CD4 molecule is a high-affinity receptor for HIV.
The clinical phases of HIV infection include the acute retroviral syndrome, chronic phase, and crisis phase.
Patients with AIDS have a high incidence of opportunistic infections (e.g., Pneumocystis carinii pneumonia, recurrent mucosal candidiasis, disseminated cytomegalovirus infection, herpes simplex, Mycobacterium tuberculosis, atypical mycobacteria, toxoplasmosis, cryptococcal meningitis, and Cryptosporidium or isospora belli infections causing persistent diarrhea) and certain tumors (e.g., Kaposi sarcoma, non-Hodgkin lymphomas, and cervix uteri carcinoma).
About 40%-60% of patients have clinically evident neurologic dysfunction, and patients may have a progressive encephalopathy clinically called AIDS-dementia complex.
Vaccine development for AIDS is difficult due to a huge degree of polymorphism in viral isolates from different AIDS patients, and prevention and effective public health measures remain the most effective defense in the fight against AIDS.

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Description

Test your knowledge on Immuno-Deficiency States and AIDS with this informative quiz. Learn about the different types of immunodeficiency states, the pathogenesis of HIV disease, clinical phases of HIV infection, and the major routes of HIV transmission. Challenge yourself with questions on the groups at risk of developing AIDS, the clinical manifestations of AIDS, and the challenges of vaccine development. Whether you are a medical student or just interested in learning about this topic, this quiz is perfect for you.