Are you a glycolysis regulation guru?
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Questions and Answers

Which enzyme catalyzes the rate-limiting step in glycolysis?

  • Phosphofructokinase-1 (correct)
  • Pyruvate kinase
  • Hexokinase
  • Lactate dehydrogenase

    • What inhibits PFK-1?

  • ATP (correct)
  • AMP
  • NADH
  • Fructose 2,6-bisphosphate

    • What activates PFK-1?

  • Fructose 2,6-bisphosphate (correct)
  • Citrate
  • Glucose-6-phosphate
  • H+

    • What is the most important allosteric regulator of PFK-1?

    <p>Fructose 2,6-bisphosphate</p> Signup and view all the answers

    What is the bifunctional enzyme that produces fructose 2,6-bisphosphate?

    <p>PFK-2/F-2,6-BPase</p> Signup and view all the answers

    What is the non-phosphorylated form of PFK-2/F-2,6-BPase called?

    <p>PFK-2</p> Signup and view all the answers

    What does PFK-2/F-2,6-BPase do in the liver?

    <p>Catalyzes the synthesis of F-2,6-BP</p> Signup and view all the answers

    What effect does fructose 2,6-bisphosphate have on PFK-1 activity?

    <p>Increases activity</p> Signup and view all the answers

    What inhibits glycolysis due to TCA cycle overload?

    <p>Citrate</p> Signup and view all the answers

    What accumulates in the cell and inhibits glycolysis due to the accumulation of lactate?

    <p>H+</p> Signup and view all the answers

    What activates glycolysis by increasing PFK-1 activity?

    <p>Fructose 2,6-bisphosphate</p> Signup and view all the answers

    What is the enzyme that converts fructose 2,6-bisphosphate to fructose 6-phosphate and inorganic phosphate?

    <p>F-2,6-BPase</p> Signup and view all the answers

    Which enzyme catalyzes the rate-limiting step in glycolysis?

    <p>Phosphofructokinase-1</p> Signup and view all the answers

    What inhibits PFK-1?

    <p>ATP</p> Signup and view all the answers

    What activates PFK-1?

    <p>Fructose 2,6-bisphosphate</p> Signup and view all the answers

    What is the most important allosteric regulator of PFK-1?

    <p>Fructose 2,6-bisphosphate</p> Signup and view all the answers

    What is the bifunctional enzyme that produces fructose 2,6-bisphosphate?

    <p>PFK-2/F-2,6-BPase</p> Signup and view all the answers

    What is the non-phosphorylated form of PFK-2/F-2,6-BPase called?

    <p>PFK-2</p> Signup and view all the answers

    What does PFK-2/F-2,6-BPase do in the liver?

    <p>Catalyzes the synthesis of F-2,6-BP</p> Signup and view all the answers

    What effect does fructose 2,6-bisphosphate have on PFK-1 activity?

    <p>Increases activity</p> Signup and view all the answers

    What inhibits glycolysis due to TCA cycle overload?

    <p>Citrate</p> Signup and view all the answers

    What accumulates in the cell and inhibits glycolysis due to the accumulation of lactate?

    <p>H+</p> Signup and view all the answers

    What activates glycolysis by increasing PFK-1 activity?

    <p>Fructose 2,6-bisphosphate</p> Signup and view all the answers

    What is the enzyme that converts fructose 2,6-bisphosphate to fructose 6-phosphate and inorganic phosphate?

    <p>F-2,6-BPase</p> Signup and view all the answers

    Which enzyme catalyzes the rate limiting step in glycolysis?

    <p>Phosphofructokinase-1</p> Signup and view all the answers

    What inhibits PFK-1?

    <p>ATP</p> Signup and view all the answers

    What activates PFK-1?

    <p>Fructose 2,6-bisphosphate</p> Signup and view all the answers

    What is the most important allosteric regulator of PFK-1?

    <p>Fructose 2,6-bisphosphate</p> Signup and view all the answers

    What enzyme produces fructose-2,6-bisphosphate?

    <p>PFK-2/F-2,6-BPase</p> Signup and view all the answers

    What is the bifunctional enzyme that produces fructose-2,6-bisphosphate?

    <p>PFK-2/F-2,6-BPase</p> Signup and view all the answers

    What form of the bifunctional enzyme functions as PFKinase-2 in the liver?

    <p>Non-phosphorylated</p> Signup and view all the answers

    What does F-2,6-BP do to the activity of PFK-1?

    <p>Activates it</p> Signup and view all the answers

    What is the effect of a high energy level on PFK-1?

    <p>Inhibition</p> Signup and view all the answers

    What is the effect of a low energy level on PFK-1?

    <p>Activation</p> Signup and view all the answers

    What is the effect of TCA cycle overload on PFK-1?

    <p>Inhibition</p> Signup and view all the answers

    What is the effect of lactate accumulation on PFK-1?

    <p>Inhibition</p> Signup and view all the answers

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