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Questions and Answers

Which enzyme catalyzes the rate-limiting step in glycolysis?

  • Phosphofructokinase-1 (correct)
  • Pyruvate kinase
  • Hexokinase
  • Lactate dehydrogenase

What inhibits PFK-1?

  • ATP (correct)
  • AMP
  • NADH
  • Fructose 2,6-bisphosphate

What activates PFK-1?

  • Fructose 2,6-bisphosphate (correct)
  • Citrate
  • Glucose-6-phosphate
  • H+

What is the most important allosteric regulator of PFK-1?

<p>Fructose 2,6-bisphosphate (C)</p> Signup and view all the answers

What is the bifunctional enzyme that produces fructose 2,6-bisphosphate?

<p>PFK-2/F-2,6-BPase (C)</p> Signup and view all the answers

What is the non-phosphorylated form of PFK-2/F-2,6-BPase called?

<p>PFK-2 (D)</p> Signup and view all the answers

What does PFK-2/F-2,6-BPase do in the liver?

<p>Catalyzes the synthesis of F-2,6-BP (B)</p> Signup and view all the answers

What effect does fructose 2,6-bisphosphate have on PFK-1 activity?

<p>Increases activity (C)</p> Signup and view all the answers

What inhibits glycolysis due to TCA cycle overload?

<p>Citrate (D)</p> Signup and view all the answers

What accumulates in the cell and inhibits glycolysis due to the accumulation of lactate?

<p>H+ (B)</p> Signup and view all the answers

What activates glycolysis by increasing PFK-1 activity?

<p>Fructose 2,6-bisphosphate (C)</p> Signup and view all the answers

What is the enzyme that converts fructose 2,6-bisphosphate to fructose 6-phosphate and inorganic phosphate?

<p>F-2,6-BPase (D)</p> Signup and view all the answers

Which enzyme catalyzes the rate-limiting step in glycolysis?

<p>Phosphofructokinase-1 (A)</p> Signup and view all the answers

What inhibits PFK-1?

<p>ATP (C)</p> Signup and view all the answers

What activates PFK-1?

<p>Fructose 2,6-bisphosphate (C)</p> Signup and view all the answers

What is the most important allosteric regulator of PFK-1?

<p>Fructose 2,6-bisphosphate (A)</p> Signup and view all the answers

What is the bifunctional enzyme that produces fructose 2,6-bisphosphate?

<p>PFK-2/F-2,6-BPase (D)</p> Signup and view all the answers

What is the non-phosphorylated form of PFK-2/F-2,6-BPase called?

<p>PFK-2 (B)</p> Signup and view all the answers

What does PFK-2/F-2,6-BPase do in the liver?

<p>Catalyzes the synthesis of F-2,6-BP (C)</p> Signup and view all the answers

What effect does fructose 2,6-bisphosphate have on PFK-1 activity?

<p>Increases activity (B)</p> Signup and view all the answers

What inhibits glycolysis due to TCA cycle overload?

<p>Citrate (C)</p> Signup and view all the answers

What accumulates in the cell and inhibits glycolysis due to the accumulation of lactate?

<p>H+ (A)</p> Signup and view all the answers

What activates glycolysis by increasing PFK-1 activity?

<p>Fructose 2,6-bisphosphate (C)</p> Signup and view all the answers

What is the enzyme that converts fructose 2,6-bisphosphate to fructose 6-phosphate and inorganic phosphate?

<p>F-2,6-BPase (B)</p> Signup and view all the answers

Which enzyme catalyzes the rate limiting step in glycolysis?

<p>Phosphofructokinase-1 (B)</p> Signup and view all the answers

What inhibits PFK-1?

<p>ATP (B)</p> Signup and view all the answers

What activates PFK-1?

<p>Fructose 2,6-bisphosphate (A)</p> Signup and view all the answers

What is the most important allosteric regulator of PFK-1?

<p>Fructose 2,6-bisphosphate (B)</p> Signup and view all the answers

What enzyme produces fructose-2,6-bisphosphate?

<p>PFK-2/F-2,6-BPase (C)</p> Signup and view all the answers

What is the bifunctional enzyme that produces fructose-2,6-bisphosphate?

<p>PFK-2/F-2,6-BPase (A)</p> Signup and view all the answers

What form of the bifunctional enzyme functions as PFKinase-2 in the liver?

<p>Non-phosphorylated (A)</p> Signup and view all the answers

What does F-2,6-BP do to the activity of PFK-1?

<p>Activates it (B)</p> Signup and view all the answers

What is the effect of a high energy level on PFK-1?

<p>Inhibition (B)</p> Signup and view all the answers

What is the effect of a low energy level on PFK-1?

<p>Activation (D)</p> Signup and view all the answers

What is the effect of TCA cycle overload on PFK-1?

<p>Inhibition (D)</p> Signup and view all the answers

What is the effect of lactate accumulation on PFK-1?

<p>Inhibition (C)</p> Signup and view all the answers

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