36 Questions
Which enzyme catalyzes the rate-limiting step in glycolysis?
Phosphofructokinase-1
What inhibits PFK-1?
ATP
What activates PFK-1?
Fructose 2,6-bisphosphate
What is the most important allosteric regulator of PFK-1?
Fructose 2,6-bisphosphate
What is the bifunctional enzyme that produces fructose 2,6-bisphosphate?
PFK-2/F-2,6-BPase
What is the non-phosphorylated form of PFK-2/F-2,6-BPase called?
PFK-2
What does PFK-2/F-2,6-BPase do in the liver?
Catalyzes the synthesis of F-2,6-BP
What effect does fructose 2,6-bisphosphate have on PFK-1 activity?
Increases activity
What inhibits glycolysis due to TCA cycle overload?
Citrate
What accumulates in the cell and inhibits glycolysis due to the accumulation of lactate?
H+
What activates glycolysis by increasing PFK-1 activity?
Fructose 2,6-bisphosphate
What is the enzyme that converts fructose 2,6-bisphosphate to fructose 6-phosphate and inorganic phosphate?
F-2,6-BPase
Which enzyme catalyzes the rate-limiting step in glycolysis?
Phosphofructokinase-1
What inhibits PFK-1?
ATP
What activates PFK-1?
Fructose 2,6-bisphosphate
What is the most important allosteric regulator of PFK-1?
Fructose 2,6-bisphosphate
What is the bifunctional enzyme that produces fructose 2,6-bisphosphate?
PFK-2/F-2,6-BPase
What is the non-phosphorylated form of PFK-2/F-2,6-BPase called?
PFK-2
What does PFK-2/F-2,6-BPase do in the liver?
Catalyzes the synthesis of F-2,6-BP
What effect does fructose 2,6-bisphosphate have on PFK-1 activity?
Increases activity
What inhibits glycolysis due to TCA cycle overload?
Citrate
What accumulates in the cell and inhibits glycolysis due to the accumulation of lactate?
H+
What activates glycolysis by increasing PFK-1 activity?
Fructose 2,6-bisphosphate
What is the enzyme that converts fructose 2,6-bisphosphate to fructose 6-phosphate and inorganic phosphate?
F-2,6-BPase
Which enzyme catalyzes the rate limiting step in glycolysis?
Phosphofructokinase-1
What inhibits PFK-1?
ATP
What activates PFK-1?
Fructose 2,6-bisphosphate
What is the most important allosteric regulator of PFK-1?
Fructose 2,6-bisphosphate
What enzyme produces fructose-2,6-bisphosphate?
PFK-2/F-2,6-BPase
What is the bifunctional enzyme that produces fructose-2,6-bisphosphate?
PFK-2/F-2,6-BPase
What form of the bifunctional enzyme functions as PFKinase-2 in the liver?
Non-phosphorylated
What does F-2,6-BP do to the activity of PFK-1?
Activates it
What is the effect of a high energy level on PFK-1?
Inhibition
What is the effect of a low energy level on PFK-1?
Activation
What is the effect of TCA cycle overload on PFK-1?
Inhibition
What is the effect of lactate accumulation on PFK-1?
Inhibition
Test your knowledge on the regulation of glycolysis with this quiz! Learn about the rate limiting step in glycolysis and the factors that inhibit or activate it. Discover the important role of fructose-2,6-bisphosphate as an allosteric regulator of PFK-1. Put your understanding to the test and see how well you know the regulation of glycolysis.
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