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Questions and Answers

Which buffer system is the most important for maintaining acid-base balance in the blood?

  • Protein buffer system
  • Carbonic-acid-bicarbonate buffer system (correct)
  • Phosphate buffer system
  • Hemoglobin buffer system

Which type of reactions consume protons in the body?

  • None of the above
  • Proton-neutral reactions
  • Proton-productive reactions
  • Proton-consumptive reactions (correct)

How do buffer systems resist changes in pH?

  • By absorbing excess H+ or OH- ions without significant changes in pH (correct)
  • By converting H+ ions to H2O molecules
  • By removing H+ ions from the solution
  • By adding OH- ions to the solution

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Study Notes

  • The pH of a solution can be affected by the addition or removal of H+ or OH- ions.
  • The carbonic-acid-bicarbonate buffer is the most important buffer for maintaining acid-base balance in the blood.
  • The equilibrium reactions of interest in the buffer system involve H+, HCO3-, H2CO3, and CO2.
  • Three types of reactions can be distinguished from the point of view of acid-base balance: proton-productive, proton-consumptive, and proton-neutral.
  • Examples of proton-productive reactions include anaerobic glycolysis, ketogenesis, lipolysis, and ureagenesis.
  • Examples of proton-consumptive reactions include gluconeogenesis and neutral and dicarboxylic amino oxidation.
  • Examples of proton-neutral reactions include complete glucose oxidation and lipogenesis from glucose acids.
  • The pH of the blood is of interest in the buffer system.
  • The concentration of H+ can be expressed in terms of an equilibrium constant and the concentrations of the other species in the reaction.
  • Buffer systems resist changes in pH.

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