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Apoptosis Mechanism Quiz

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Questions and Answers

What is the main purpose of apoptosis in eukaryotic cells?

To induce an inflammatory response

To prevent cell turnover

To promote cell growth

To eliminate unwanted and defective cells (correct)

Which of the following disorders can result from improper regulation of apoptosis?

Hypertension

Cancer (correct)

Diabetes

Osteoporosis

What type of signals can trigger apoptosis?

A wide variety of signals including Fas ligand, tumor necrosis factor, and growth factor withdrawal (correct)

Only Fas ligand

Only growth factor withdrawal

Only viral or bacterial infection

What is the main role of caspases in the apoptotic process?

To act as effectors of the cell death pathway Signup and view all the answers

Which of the following proteins can be cleaved by activated caspases during apoptosis?

Lamins Signup and view all the answers

What happens to cells during normal development and turnover?

They undergo apoptosis Signup and view all the answers

What is the main purpose of balancing cell loss and cell gain in metazoans?

To maintain the complex architecture of tissues Signup and view all the answers

What is a significant similarity between mitosis and apoptosis?

Both processes involve chromatin condensation Signup and view all the answers

What sets apoptotic cells apart from cells undergoing mitosis?

Apoptotic cells display a nucleosomal ladder pattern during DNA degradation Signup and view all the answers

How can manipulation of the cell cycle affect the apoptotic response?

It can prevent or induce an apoptotic response depending on the cellular context Signup and view all the answers

What role do proliferative proteins play in relation to apoptosis?

They may act to sensitize cells to apoptosis Signup and view all the answers

What is the mechanism by which apoptotic cells are typically removed from the body?

Phagocytosis by adjacent cells or macrophages Signup and view all the answers

What happens to DNA in apoptotic cells that sets them apart from mitotic cells?

DNA is degraded at internucleosomal linker sites, yielding DNA fragments in multiples of 180 bp Signup and view all the answers

What is a common feature of both mitosis and apoptosis?

Cells lose substrate attachment during both processes Signup and view all the answers

Why is it important to balance cell loss and cell gain in metazoans?

To maintain tissue architecture and allow adaptation to changing circumstances Signup and view all the answers

What is the relationship between genes involved in cell cycle progression and apoptosis regulation?

Genes involved in cell cycle progression may regulate apoptosis Signup and view all the answers