28 Questions
What percentage of PCN-allergic patients are allergic to cephalosporins?
2-10%
Which type of PCN reaction would contraindicate giving a cephalosporin?
Anaphylaxis
What type of reaction is associated with hives in response to penicillin (PCN)?
IgE-mediated, Type I reaction
In terms of allergic reactions, why does Rule 3 suggest giving a cephalosporin?
Morbilliform rash indicates safety for cephalosporin use
Which type of PCN-allergic patients can safely take cephalosporins according to the text?
Those allergic to the pink pentagon
What is the suggested course of action if the patient had hives following a penicillin reaction?
Consider giving a cephalosporin with caution
Which type of organisms are classified as gram-positive?
Staphylococcus
Which organisms fall under the category of gram-negative bugs?
Neisseria gonorrhoeae
What is the significance of a beta-lactam ring in antibiotics?
It interacts with penicillin-binding proteins.
Why is printing multiple copies of the Course Manual content considered a violation of copyright?
It violates the terms of use set by the provider.
Which antibiotic class is known for having a wide antimicrobial spectrum?
Fluoroquinolones
Which antibiotic is a good choice for Mycoplasma and community-acquired-MRSA?
Doxycycline
Which antibiotic is effective against Legionella sp.?
Clarithromycin
Which antibiotic is a good choice for Streptococcus and atypical pathogens?
Azithromycin
Which antibiotic is not effective against Enterococcus and Listeria?
Doxycycline
Which antibiotic is a good choice for Proteus mirabilis but not for Staph: MSSA?
Cefdinir
Which antibiotic is indicated for infections caused by Klebsiella?
Cefixime
Can amoxicillin effectively eliminate Drug-resistant Strep pneumoniae (DRSP)?
No, DRSP is resistant to amoxicillin
How can you identify if a bacterial strain produces beta-lactamase?
By using a biochemical test to detect the enzyme
What is the maximum adult dose for Amoxicillin/Clavulanic acid (Augmentin)?
2000 mg twice daily
Which of the following organisms are NOT typically susceptible to Amoxicillin/Clavulanic acid (Augmentin)?
Staphylococcus aureus
Is TMP-SMX (Bactrim, Septra) effective against Strep organisms?
No, TMP-SMX has no activity against Streptococcus species
If a patient is allergic to penicillin, can you safely prescribe a cephalosporin?
Yes, because being allergic to penicillin does not mean they are allergic to cephalosporin
If a patient is allergic to the pink pentagon in penicillin, can they safely take a cephalosporin?
Yes, because the pink pentagon is not present in cephalosporins
If a patient is allergic to the blue box in penicillin, can they safely take a cephalosporin?
Yes, because the blue box is not present in cephalosporins
Do all beta-lactam antibiotics trigger the same type of allergic reactions?
No, because different beta-lactam antibiotics have different side chains that impact allergenicity
Can a patient who is allergic to both penicillin and cephalosporin be prescribed another class of antibiotics?
No, because allergies to penicillins and cephalosporins usually indicate cross-reactivity with other classes of antibiotics
Is being allergic to beta-lactam antibiotics common among patients?
No, beta-lactam allergies are very rare and affect only a small percentage of patients
Test your knowledge on key concepts covered in the Advanced Practice Education Associates Antibiotics course manual. Learn about the differences between gram-positive and gram-negative organisms, beta-lactam ring, allergies, and antimicrobial spectra of antibiotic classes.
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