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Questions and Answers

What type of tumors are known to originate during intrauterine life?

  • Embryonal tumors (correct)
  • Sarcomas
  • Leukemias
  • Lymphomas

Which risk factor is associated with a higher chance of cancer in childhood?

  • Ionizing radiation (correct)
  • Exposure to allergens
  • Living in urban environments
  • Consuming organic food

Which of the following is NOT a common childhood cancer?

  • Melanoma (correct)
  • Neuroblastoma
  • Retinoblastoma
  • Lymphoma

What is a significant factor associated with breast cancer risk in women according to studies?

<p>Hormone Replacement Therapy (B)</p> Signup and view all the answers

Which type of genetic alteration is primarily associated with cancer development?

<p>Alterations in oncogenes and tumor-suppressor genes (D)</p> Signup and view all the answers

Which of the following substances are classified as biochemical markers for tumors?

<p>Hormones (A)</p> Signup and view all the answers

What is the prerequisite for metastasis in cancer progression?

<p>Invasion (B)</p> Signup and view all the answers

Which phenomenon describes the spread of cancer from its primary site to distant sites?

<p>Metastasis (D)</p> Signup and view all the answers

Which step is NOT part of the metastatic process?

<p>Cell duplication (B)</p> Signup and view all the answers

What is the term for the process by which cancer cells evolve to migrate and survive in foreign microenvironments?

<p>Epithelial-mesenchymal transition (B)</p> Signup and view all the answers

What role do lytic enzymes play in cancer invasion?

<p>Break down surrounding tissue (C)</p> Signup and view all the answers

Which of the following factors can influence organ tropism in cancer cells?

<p>Chemokines (B)</p> Signup and view all the answers

Which statement about the metastatic process is true?

<p>Metastasis occurs via lymphatic and vascular systems. (A)</p> Signup and view all the answers

What term describes the loss of differentiation in cancer cells?

<p>Anaplasia (D)</p> Signup and view all the answers

Which characteristic distinguishes malignant tumors from benign tumors?

<p>Invasive nature (C)</p> Signup and view all the answers

What mechanism allows cancer cells to develop a selective growth advantage?

<p>Clonal proliferation (C)</p> Signup and view all the answers

What is the role of oncogenes in cancer development?

<p>They drive abnormal cell proliferation. (D)</p> Signup and view all the answers

Which is NOT one of the stages of cancer development?

<p>Tumor suppression (B)</p> Signup and view all the answers

What is a characteristic of poorly differentiated cancer cells?

<p>High mitotic index (C)</p> Signup and view all the answers

Which of the following best describes genetic mutations in cancer?

<p>A critical number of mutations is needed for cancer. (C)</p> Signup and view all the answers

What is the primary function of proto-oncogenes in normal cells?

<p>To regulate normal cell proliferation (C)</p> Signup and view all the answers

How does chronic inflammation contribute to the development of cancer?

<p>By promoting conditions favorable for tumor growth (C)</p> Signup and view all the answers

What role do tumor-associated macrophages (TAM) play in cancer progression?

<p>Promoting tumor survival and growth (D)</p> Signup and view all the answers

What does the presence of tumor markers indicate?

<p>Potential risk for developing cancer (C)</p> Signup and view all the answers

What is the primary difference between an oncogene and an anti-oncogene?

<p>Oncogenes are mutated versions of normal genes that promote cancer, whereas anti-oncogenes prevent it (A)</p> Signup and view all the answers

How do cancer cells achieve replicative immortality?

<p>Through the activation of telomerase (D)</p> Signup and view all the answers

What does the TNM staging system primarily evaluate?

<p>Extent of tumor spread and metastasis (C)</p> Signup and view all the answers

What is angiogenesis's role in cancer development?

<p>It facilitates the growth and spread of cancer by creating a blood supply (B)</p> Signup and view all the answers

How might mutagen exposure affect future generations in terms of cancer risk?

<p>Exposure in somatic cells can also transmit risks through epigenetic changes (C)</p> Signup and view all the answers

What is a common consequence of chronic inflammation caused by Helicobacter pylori?

<p>Increased risk of stomach cancer (C)</p> Signup and view all the answers

Which of the following is a recognized carcinogen linked to increased cancer risk?

<p>Tobacco (A)</p> Signup and view all the answers

Among the following options, which dietary factor can increase cancer risk?

<p>Excessive consumption of fried foods (B)</p> Signup and view all the answers

Which viral infection is associated with an increased risk of cervical cancer?

<p>Human papilloma virus (HPV) (D)</p> Signup and view all the answers

What risk factor is associated with increased cancer risk in women who use oral contraceptives?

<p>Increased breast cancer risk (B)</p> Signup and view all the answers

What impact does obesity have on cancer risk?

<p>Increases risk of multiple types of cancer (C)</p> Signup and view all the answers

Which environmental exposure is linked to an increased risk of lung cancer?

<p>Passive smoke (B)</p> Signup and view all the answers

What is the primary risk factor associated with Kaposi sarcoma?

<p>Human T cell leukemia-lymphoma virus (D)</p> Signup and view all the answers

Flashcards

Embryonal tumors

Tumors that develop before birth. These abnormal growths are a result of early developmental errors.

Ionizing radiation and childhood cancer

Exposure to ionizing radiation, especially during childhood, increases the risk of cancer.

Melanoma and childhood cancer

Melanoma is a skin cancer and is not typically seen in children.

Hormone Replacement Therapy and Breast Cancer

Hormone Replacement Therapy (HRT) has been linked to an increased risk of breast cancer in women.

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Oncogenes and tumor suppressor genes in cancer

Cancer is often caused by changes in genes called oncogenes and tumor suppressor genes.

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Hormones as biochemical markers

Hormones produced by the body or tumor cells can act as indicators of cancer.

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Invasion in cancer progression

The initial step in cancer spreading, where cancer cells break free from the main tumor and invade surrounding tissue.

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Metastasis

The process of cancer spreading from the primary site to distant organs.

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Angiogenesis in cancer

This is the process of getting new blood vessels. It is essential for tumors to grow and spread.

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Cell duplication and metastasis

Cell duplication is not part of metastasis, which involves: 1) invasion, 2) intravasation, 3) extravasation, and 4) colonization.

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Epithelial-mesenchymal transition (EMT)

The ability of cancer cells to adapt and survive in new environments. They become more flexible and can change their form.

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Role of lytic enzymes in cancer

Lytic enzymes breakdown proteins and other tissues and help cancer cells invade.

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Organ tropism in cancer cells

Cancer's tendency to spread to certain organs is influenced by factors like the specific type of cell and the presence of certain attractants.

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Metastatic routes

Metastasis occurs through the lymphatic system and blood vessels. This is how cancer cells travel.

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Anaplasia

Anaplasia is when cancer cells lose their normal characteristics.

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Malignant vs. Benign tumors

Malignant tumors are cancerous tumors that spread and invade surrounding tissues. Benign tumors do not.

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Clonal proliferation

This is a key feature of cancer. Cancer cells multiply and grow uncontrollably, giving them an advantage over normal cells.

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Oncogenes and cancer

Oncogenes are mutated genes that accelerate cell division.

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Stages of cancer development

Cancer develops in stages, including Initiation, Promotion, Progression, and Metastasis.

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Poorly differentiated cancer cells

Cells with low differentiation divide rapidly, which is a sign of aggressive cancer.

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Genetic mutations and cancer

Multiple genetic mutations are needed for cancer to develop and spread.

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Proto-oncogenes

Proto-oncogenes are normal genes involved in controlling cell growth. But they can become oncogenes when mutated.

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Chronic inflammation and cancer

Chronic inflammation can create an environment that promotes tumor growth.

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Tumor-associated macrophages (TAMs)

These immune cells actually help tumors grow and survive.

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Tumor markers

The presence of certain substances in the body can signal the potential for cancer.

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Oncogenes vs. anti-oncogenes

Oncogenes promote cancer, whereas anti-oncogenes, also known as tumor suppressor genes, suppress cancer growth.

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Telomerase and replicative immortality

This is a key step in becoming 'immortal'. Cancer cells can keep dividing by reactivating a special enzyme.

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TNM staging system

The TNM system categorizes tumors by their: 1) T: Tumor Size, 2) N: Lymph Node involvement, and 3) M: Metastasis.

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Mutagens and cancer

Mutagens are substances that can cause mutations in DNA. These mutations can increase cancer risk.

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Helicobacter pylori and cancer

Helicobacter pylori infection can lead to chronic inflammation and increase the risk of stomach cancer.

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Tobacco and cancer

Tobacco is a well-known carcinogen that is linked to an increased risk of various types of cancer.

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Dietary factors and cancer risk

Fried foods, processed meats, and a high intake of saturated fats can increase the risk of cancer.

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HPV and cervical cancer

HPV is a viral infection that can lead to cervical cancer.

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Oral contraceptives and cancer

Oral contraceptives have been linked to an increased risk of breast cancer in some women.

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Obesity and cancer

Obesity is a major risk factor for various types of cancer.

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Passive smoke and cancer

Passive smoke inhalation can increase the risk of lung cancer.

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HTLV and Kaposi Sarcoma

Human T cell leukemia-lymphoma virus (HTLV) is associated with Kaposi sarcoma.

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