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Questions and Answers
What is the primary therapeutic effect of hyoscyamine?
What is the primary therapeutic effect of hyoscyamine?
- Relax muscles of the GI tract to treat spasms (correct)
- Stimulate the central nervous system
- Enhance secretion of digestive enzymes
- Increase gastric motility
What is the mechanism of action of hyoscyamine?
What is the mechanism of action of hyoscyamine?
- Enhancing norepinephrine release
- Stimulating serotonin receptors
- Blocking the action of acetylcholine on muscarinic receptors (correct)
- Inhibiting dopamine receptors
Which side effect is NOT commonly associated with hyoscyamine?
Which side effect is NOT commonly associated with hyoscyamine?
- Increased salivation (correct)
- Blurred vision
- Urinary retention
- Dry mouth
Which population may be particularly affected by the side effects of hyoscyamine?
Which population may be particularly affected by the side effects of hyoscyamine?
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What common condition is hyoscyamine most often used to treat?
What common condition is hyoscyamine most often used to treat?
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Study Notes
Antispasmodic Overview
- Prototype Drug: Hyoscyamine is the primary representative drug in the antispasmodic class.
Therapeutic Effects
- Hyoscyamine relaxes the smooth muscles of the gastrointestinal (GI) tract, providing relief from spasms.
- Effective in reducing pain associated with conditions such as Irritable Bowel Syndrome (IBS).
Mechanism of Action (MOA)
- Functions as an anticholinergic agent.
- Blocks the action of acetylcholine specifically on muscarinic receptors located in smooth muscles, secretory glands, and the central nervous system, leading to muscle relaxation and reduced secretions.
Side Effects of Hyoscyamine
- Commonly reported side effects include:
- Dry mouth
- Blurred vision
- Constipation
- Urinary retention
- Dry eyes
- Drowsiness
- Sedation
- Decreased sweating
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