Antiseizure Drugs Mechanism Quiz
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Questions and Answers

Which of the following is NOT a mechanism of action of antiseizure drugs?

  • Enhancement of GABAergic (inhibitory) transmission
  • Diminution of excitatory (usually glutamatergic) transmission
  • Increase in dopamine levels in the brain (correct)
  • Modification of ionic conductance
  • Which antiseizure drug produces enhancement of GABA-mediated inhibition?

  • Carbamazepine
  • Phenytoin (correct)
  • Ethosuximide
  • Lamotrigine
  • Which antiseizure drug has an impotent effect on the T-type calcium channels in thalamic neurons?

  • Lamotrigine
  • Carbamazepin
  • Phenytoin
  • Ethosuximide (correct)
  • Which antiseizure drug inhibits central effects of excitatory amino acids?

    <p>Tiagabine</p> Signup and view all the answers

    Which antiseizure drug produces a voltage-dependent inactivation of sodium channels?

    <p>Lamotrigine</p> Signup and view all the answers

    Which drug is indicated for partial and generalized tonic-clonic seizures?

    <p>Valproate</p> Signup and view all the answers

    Phenytoin is used for the treatment of:

    <p>Grand mal epilepsy</p> Signup and view all the answers

    Which adverse effect is dose-related and caused by phenytoin?

    <p>Gingival hyperplasia</p> Signup and view all the answers

    Which antiseizure drug induces hepatic microsomal enzymes?

    <p>Phenytoin</p> Signup and view all the answers

    Which antiseizure drug is the drug of choice for partial seizures?

    <p>Carbamazepine</p> Signup and view all the answers

    The mechanism of action of carbamazepine appears to be similar to that of:

    <p>Phenytoin</p> Signup and view all the answers

    Which antiseizure drug is also effective in treating trigeminal neuralgia?

    <p>Carbamazepine</p> Signup and view all the answers

    The most common dose-related adverse effects of carbamazepine are:

    <p>Diplopia, ataxia, and nausea</p> Signup and view all the answers

    Which antiseizure drug is the drug of choice for status epilepticus in infants and children?

    <p>Phenobarbital sodium</p> Signup and view all the answers

    Barbiturates are used in the emergency treatment of status epilepticus in infants and children because of:

    <p>Short onset and duration of action</p> Signup and view all the answers

    Which antiseizure drug binds to an allosteric regulatory site on the GABA-BZ receptor and increases the duration of the Cl- channels openings?

    <p>Topiramate</p> Signup and view all the answers

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