Antiresorptive Agents and Bone Resorption Inhibition
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Questions and Answers

How do bisphosphonates and denosumab affect osteoclast function?

  • Decrease apoptosis
  • Enhance bone resorption
  • Promote osteoclast differentiation
  • Increase apoptosis (correct)

    • What is compromised in patients receiving bisphosphonate therapy?

  • Osteoblastic activity
  • Bone formation
  • Osteoclastic resorption (correct)
  • Bone mineralization

    • What is the role of osteoclasts in the action of bisphosphonates?

  • Osteoclasts stimulate the production of bone-building cells
  • Osteoclasts promote the growth of new bone tissue
  • Osteoclasts are not involved in the action of bisphosphonates
  • Osteoclasts take up the drug during bone remodeling (correct)

    • Which process is inhibited by bisphosphonates and denosumab?

    <p>Osteoclast differentiation</p> Signup and view all the answers

    What aspect of bone health is negatively impacted by bisphosphonate therapy?

    <p>Bone remodeling efficiency</p> Signup and view all the answers

    What effect do bisphosphonates and denosumab have on bone resorption?

    <p>Decrease</p> Signup and view all the answers

    How are bisphosphonates incorporated into the bone matrix?

    <p>By binding to the bone matrix and being incorporated during bone remodeling</p> Signup and view all the answers

    How do bisphosphonates contribute to bone remodeling?

    <p>By inhibiting osteoclastic function and inducing apoptotic cell death</p> Signup and view all the answers

    Which process is hindered by bisphosphonate therapy?

    <p>Normal bone remodeling</p> Signup and view all the answers

    What is significantly affected in patients on bisphosphonate therapy?

    <p>Bone density</p> Signup and view all the answers

    What is the ultimate result of the actions of bisphosphonates and denosumab on osteoclasts?

    <p>Decreased bone resorption</p> Signup and view all the answers

    Which cellular activity is impaired by bisphosphonate therapy?

    <p>Osteoclast function</p> Signup and view all the answers

    Which of the following is a common outcome of the actions of bisphosphonates and denosumab?

    <p>Increased apoptosis</p> Signup and view all the answers

    What is the primary mechanism by which bisphosphonates inhibit osteoclastic resorption?

    <p>By inhibiting osteoclastic function and inducing apoptotic cell death</p> Signup and view all the answers

    What is the impact of bisphosphonates on osteoclasts?

    <p>Bisphosphonates inhibit osteoclastic function and induce apoptotic cell death</p> Signup and view all the answers

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