Antiresorptive Agents and Bone Resorption Inhibition

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How do bisphosphonates and denosumab affect osteoclast function?

Decrease apoptosis

Enhance bone resorption

Promote osteoclast differentiation

Increase apoptosis (correct)

What is compromised in patients receiving bisphosphonate therapy?

Osteoblastic activity

Bone formation

Osteoclastic resorption (correct)

Bone mineralization

What is the role of osteoclasts in the action of bisphosphonates?

Osteoclasts stimulate the production of bone-building cells

Osteoclasts promote the growth of new bone tissue

Osteoclasts are not involved in the action of bisphosphonates

Osteoclasts take up the drug during bone remodeling (correct)

Which process is inhibited by bisphosphonates and denosumab?

Osteoclast differentiation Signup and view all the answers

What aspect of bone health is negatively impacted by bisphosphonate therapy?

Bone remodeling efficiency Signup and view all the answers

What effect do bisphosphonates and denosumab have on bone resorption?

Decrease Signup and view all the answers

How are bisphosphonates incorporated into the bone matrix?

By binding to the bone matrix and being incorporated during bone remodeling Signup and view all the answers

How do bisphosphonates contribute to bone remodeling?

By inhibiting osteoclastic function and inducing apoptotic cell death Signup and view all the answers

Which process is hindered by bisphosphonate therapy?

Normal bone remodeling Signup and view all the answers

What is significantly affected in patients on bisphosphonate therapy?

Bone density Signup and view all the answers

What is the ultimate result of the actions of bisphosphonates and denosumab on osteoclasts?

Decreased bone resorption Signup and view all the answers

Which cellular activity is impaired by bisphosphonate therapy?

Osteoclast function Signup and view all the answers

Which of the following is a common outcome of the actions of bisphosphonates and denosumab?

Increased apoptosis Signup and view all the answers

What is the primary mechanism by which bisphosphonates inhibit osteoclastic resorption?