Antipsychotic Drugs: Classes, Structure-Activity Relationships, and Therapeutic Applications

Treatment of psychosis, hallucinations, excitation, and as anti-emetic (D2-blocker)

Typical antipsychotics act by blocking the action of dopamine D2 receptors

Positive symptoms (hallucinations and delusions) and Negative symptoms (apathy and social withdrawal)

<p>Extra-pyramidal symptoms, anti-cholinergic effects, anti-histaminic effects, anti-adrenergic effects, photosensitivity, and retinal toxicity</p> Signup and view all the answers

<p>Tricyclic structure, sulfur atom, and electron withdrawing group with an unshared electron at C2</p> Signup and view all the answers

<p>Neuroleptics and Major tranquilizers</p> Signup and view all the answers

<p>CF3</p> Signup and view all the answers

<p>Increased antihistaminic effect and decreased antipsychotic effect</p> Signup and view all the answers

<p>Substituents at C1</p> Signup and view all the answers

<p>Interfere with the sulfur atom receptor binding</p> Signup and view all the answers

<p>3</p> Signup and view all the answers

<p>Increases activity</p> Signup and view all the answers

<p>Chlorpromazine</p> Signup and view all the answers

<p>CPZ index</p> Signup and view all the answers

<p>Sedation (H1 blocker) &amp; hypotension (α 1-blockage)</p> Signup and view all the answers

<p>Less sedation &amp; less hypotensive</p> Signup and view all the answers