Antimycobacterial Drugs

Why are mycobacterial infections difficult to treat with antibiotics?

Which drug is considered a first-line drug for the treatment of tuberculosis?

What is the recommended duration of treatment for uncomplicated pulmonary tuberculosis?

Why is a combination of at least two effective drugs recommended for the treatment of mycobacterial infections?

What makes mycobacteria resistant to antibiotics?

Challenges in Treating Mycobacterial Infections

Mycobacterial infections are difficult to treat with antibiotics due to the unique properties of the bacterial cell wall, which makes it hard for antibiotics to penetrate and reach their target.

First-Line Drug for Tuberculosis

Isoniazid is considered a first-line drug for the treatment of tuberculosis.

Duration of Treatment for Pulmonary Tuberculosis

The recommended duration of treatment for uncomplicated pulmonary tuberculosis is 6-9 months.

Importance of Combination Therapy

A combination of at least two effective drugs is recommended for the treatment of mycobacterial infections to prevent the emergence of antibiotic resistance.

Mechanisms of Antibiotic Resistance

Mycobacteria can become resistant to antibiotics due to genetic mutations, which alter the target site of the antibiotic, or through the production of enzymes that degrade the antibiotic.
Mycobacteria can also develop resistance by reducing the permeability of their cell wall, making it harder for antibiotics to penetrate.

Test your knowledge about drugs used to treat mycobacterial infections such as tuberculosis and leprosy. Learn about the challenges in treating these infections due to slow growth, intracellular location, and impermeable cell wall.