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Questions and Answers
Why are mycobacterial infections difficult to treat with antibiotics?
Why are mycobacterial infections difficult to treat with antibiotics?
- They have a fast rate of growth
- They do not develop resistance to antimicrobial agents
- Their cell wall is impermeable to many drugs (correct)
- They are easily accessible to drugs
Which drug is considered a first-line drug for the treatment of tuberculosis?
Which drug is considered a first-line drug for the treatment of tuberculosis?
- Isoniazid (correct)
- Streptomycin
- Ethambutol
- Pyrazinamide
What is the recommended duration of treatment for uncomplicated pulmonary tuberculosis?
What is the recommended duration of treatment for uncomplicated pulmonary tuberculosis?
- 12 months
- 6 months (correct)
- 3 months
- 9 months
Why is a combination of at least two effective drugs recommended for the treatment of mycobacterial infections?
Why is a combination of at least two effective drugs recommended for the treatment of mycobacterial infections?
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What makes mycobacteria resistant to antibiotics?
What makes mycobacteria resistant to antibiotics?
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Study Notes
Challenges in Treating Mycobacterial Infections
- Mycobacterial infections are difficult to treat with antibiotics due to the unique properties of the bacterial cell wall, which makes it hard for antibiotics to penetrate and reach their target.
First-Line Drug for Tuberculosis
- Isoniazid is considered a first-line drug for the treatment of tuberculosis.
Duration of Treatment for Pulmonary Tuberculosis
- The recommended duration of treatment for uncomplicated pulmonary tuberculosis is 6-9 months.
Importance of Combination Therapy
- A combination of at least two effective drugs is recommended for the treatment of mycobacterial infections to prevent the emergence of antibiotic resistance.
Mechanisms of Antibiotic Resistance
- Mycobacteria can become resistant to antibiotics due to genetic mutations, which alter the target site of the antibiotic, or through the production of enzymes that degrade the antibiotic.
- Mycobacteria can also develop resistance by reducing the permeability of their cell wall, making it harder for antibiotics to penetrate.
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