Podcast
Questions and Answers
What is the mechanism of action of sulfonamides?
What is the mechanism of action of sulfonamides?
Why can PABA in multivitamins cause therapy failure when taking sulfonamide antibiotics?
Why can PABA in multivitamins cause therapy failure when taking sulfonamide antibiotics?
Which of the following bacterial species is not susceptible to sulfonamides?
Which of the following bacterial species is not susceptible to sulfonamides?
Why are sulfonamides considered antimetabolites?
Why are sulfonamides considered antimetabolites?
Signup and view all the answers
In which bacterial species would sulfonamides likely be effective due to their mechanism of action?
In which bacterial species would sulfonamides likely be effective due to their mechanism of action?
Signup and view all the answers
When tetracycline is combined with gentamicin, what is the expected result?
When tetracycline is combined with gentamicin, what is the expected result?
Signup and view all the answers
What type of activity is exhibited when ampicillin is combined with vancomycin against E. coli?
What type of activity is exhibited when ampicillin is combined with vancomycin against E. coli?
Signup and view all the answers
Based on the text, what is a resistant mechanism to cell wall or membrane agents?
Based on the text, what is a resistant mechanism to cell wall or membrane agents?
Signup and view all the answers
In the context of phage therapy, what is the main characteristic of bacteriophages?
In the context of phage therapy, what is the main characteristic of bacteriophages?
Signup and view all the answers
What was the outcome for the pediatric patient with cystic fibrosis who received a 3-phage cocktail for a Mycobacterium abscessus infection?
What was the outcome for the pediatric patient with cystic fibrosis who received a 3-phage cocktail for a Mycobacterium abscessus infection?
Signup and view all the answers
How did the personalized phage treatment for a patient with P. aeruginosa prosthetic joint infection differ from standard treatment?
How did the personalized phage treatment for a patient with P. aeruginosa prosthetic joint infection differ from standard treatment?
Signup and view all the answers
What is the percentage of E.coli isolates in the UK resistant to fluoroquinolones in the years 2001-2006?
What is the percentage of E.coli isolates in the UK resistant to fluoroquinolones in the years 2001-2006?
Signup and view all the answers
Which antibiotic is cited as the first choice against Legionella pneumophila?
Which antibiotic is cited as the first choice against Legionella pneumophila?
Signup and view all the answers
Which fluoroquinolone has been recommended by 5 ID specialists as of December 2023?
Which fluoroquinolone has been recommended by 5 ID specialists as of December 2023?
Signup and view all the answers
What condition can Clostridioides difficile infection potentially lead to?
What condition can Clostridioides difficile infection potentially lead to?
Signup and view all the answers
Which condition accounted for the most estimated unnecessary fluoroquinolone prescriptions in medical offices and EDs in 2014?
Which condition accounted for the most estimated unnecessary fluoroquinolone prescriptions in medical offices and EDs in 2014?
Signup and view all the answers
Which pathogen has developed resistance to many fluoroquinolones?
Which pathogen has developed resistance to many fluoroquinolones?
Signup and view all the answers
What can fluoroquinolone use lead to besides resistance?
What can fluoroquinolone use lead to besides resistance?
Signup and view all the answers
Which setting saw nearly 32 million fluoroquinolone prescriptions dispensed from U.S. outpatient pharmacies?
Which setting saw nearly 32 million fluoroquinolone prescriptions dispensed from U.S. outpatient pharmacies?
Signup and view all the answers
Which statement about fluoroquinolones is true?
Which statement about fluoroquinolones is true?
Signup and view all the answers
What is a common side effect associated with fluoroquinolones?
What is a common side effect associated with fluoroquinolones?
Signup and view all the answers
What is the mechanism of action of Trimethoprim?
What is the mechanism of action of Trimethoprim?
Signup and view all the answers
Which antibiotic is recommended by IDSA guidance for the management of initial C.difficile episodes?
Which antibiotic is recommended by IDSA guidance for the management of initial C.difficile episodes?
Signup and view all the answers
What is the main adverse reaction associated with Sulfonamides?
What is the main adverse reaction associated with Sulfonamides?
Signup and view all the answers
What is the mode of action of Fidaxomicin?
What is the mode of action of Fidaxomicin?
Signup and view all the answers
Why should fluoroquinolones be reserved for important uses according to IDSA guidelines?
Why should fluoroquinolones be reserved for important uses according to IDSA guidelines?
Signup and view all the answers
Which antibiotic is indicated for anaerobic or mixed intra-abdominal infections?
Which antibiotic is indicated for anaerobic or mixed intra-abdominal infections?
Signup and view all the answers
What is the primary target of Rifampin's mechanism of action?
What is the primary target of Rifampin's mechanism of action?
Signup and view all the answers
What is the primary target for Quinolones (Q) and Fluoroquinolones (FQs)?
What is the primary target for Quinolones (Q) and Fluoroquinolones (FQs)?
Signup and view all the answers
What is the mechanism of killing associated with Aminoglycosides and Fluoroquinolones?
What is the mechanism of killing associated with Aminoglycosides and Fluoroquinolones?
Signup and view all the answers
Which enzyme is responsible for adding negative supercoils to DNA?
Which enzyme is responsible for adding negative supercoils to DNA?
Signup and view all the answers
What was the first plasmid-mediated Fluoroquinolone resistance reported in?
What was the first plasmid-mediated Fluoroquinolone resistance reported in?
Signup and view all the answers
Which of the following is a mechanism that provides low-level protection against Fluoroquinolones?
Which of the following is a mechanism that provides low-level protection against Fluoroquinolones?
Signup and view all the answers
What do multiple copies of qnr genes confer resistance to in the absence of chromosomal mutations?
What do multiple copies of qnr genes confer resistance to in the absence of chromosomal mutations?
Signup and view all the answers
What factor affects the resistance rates of uncomplicated ESBL positive E.coli isolates to Fluoroquinolones?
What factor affects the resistance rates of uncomplicated ESBL positive E.coli isolates to Fluoroquinolones?
Signup and view all the answers
Which region of the topoisomerases is associated with resistance to Quinolones and Fluoroquinolones?
Which region of the topoisomerases is associated with resistance to Quinolones and Fluoroquinolones?
Signup and view all the answers
