Podcast
Questions and Answers
What is the mortality rate for Carbapenem resistant Acinetobacter infections?
What is the mortality rate for Carbapenem resistant Acinetobacter infections?
- 10-30%
- 30-80%
- 52% (correct)
- 20-50%
Which type of resistance mechanism involves altered targets like PBP2a for MRSA and Dala-Dlac for VRE?
Which type of resistance mechanism involves altered targets like PBP2a for MRSA and Dala-Dlac for VRE?
- Antibiotic inactivating enzymes
- Altered target (correct)
- Reduced accumulation
- Intrinsic resistance
What is the primary function of β-lactamase enzymes in antibiotic resistance?
What is the primary function of β-lactamase enzymes in antibiotic resistance?
- Reducing permeability
- Increasing target binding
- Inactivating antibiotics (correct)
- Enhancing accumulation
Which bacterial pathogen is known to be cephalosporin resistant?
Which bacterial pathogen is known to be cephalosporin resistant?
What is the common outcome of reduced permeability in Gram-positive bacteria?
What is the common outcome of reduced permeability in Gram-positive bacteria?
Which bacterial species exhibits intrinsic resistance due to low affinity PBPs that bind β-lactams 1000-fold less than other species?
Which bacterial species exhibits intrinsic resistance due to low affinity PBPs that bind β-lactams 1000-fold less than other species?
What is the antimicrobial resistant category that Pseudomonas aeruginosa belongs to based on the given information?
What is the antimicrobial resistant category that Pseudomonas aeruginosa belongs to based on the given information?
Which antimicrobial agent is NOT listed under the Aminoglycosides category in the provided text?
Which antimicrobial agent is NOT listed under the Aminoglycosides category in the provided text?
In the context of β-Lactamase Mediated Resistance, which of the following antibiotic categories is specifically mentioned as a treatment option?
In the context of β-Lactamase Mediated Resistance, which of the following antibiotic categories is specifically mentioned as a treatment option?
According to the provided information, which antibiotic category is associated with Colistin and Polymyxin B?
According to the provided information, which antibiotic category is associated with Colistin and Polymyxin B?
From the provided COVID-19 and Bacterial Infections text, what percentage of patients with COVID-19 were prescribed early empiric antibacterial therapy?
From the provided COVID-19 and Bacterial Infections text, what percentage of patients with COVID-19 were prescribed early empiric antibacterial therapy?
In the context of Multi-drug resistant Enterobacteriaceae, what does MDR stand for?
In the context of Multi-drug resistant Enterobacteriaceae, what does MDR stand for?
What is the most common mechanism of -lactam resistance in Gram-negative bacteria?
What is the most common mechanism of -lactam resistance in Gram-negative bacteria?
Which enzyme is responsible for inactivating -lactam antibiotics?
Which enzyme is responsible for inactivating -lactam antibiotics?
What is the target of modified cross-linking for VRE bacteria?
What is the target of modified cross-linking for VRE bacteria?
Which type of -lactamase is associated with cephalosporin resistance?
Which type of -lactamase is associated with cephalosporin resistance?
What is the primary effect of altered porin production and -lactamase production in Gram-negative cells?
What is the primary effect of altered porin production and -lactamase production in Gram-negative cells?
Which type of -lactamase is commonly encountered with metallo substrates like IMP, VIM, NDM?
Which type of -lactamase is commonly encountered with metallo substrates like IMP, VIM, NDM?
Why do failures of Cephalosporin therapy occur in serious infections caused by ESBL-positive bacteria?
Why do failures of Cephalosporin therapy occur in serious infections caused by ESBL-positive bacteria?
Why is it not recommended to treat organisms with an inducible AmpC with a 3rd generation cephalosporin?
Why is it not recommended to treat organisms with an inducible AmpC with a 3rd generation cephalosporin?
What type of resistance do Metallo--lactamases (MBLs) confer?
What type of resistance do Metallo--lactamases (MBLs) confer?
Which antibiotic is VIM, IMP, and NDM resistant to due to Metallo--lactamases (MBLs)?
Which antibiotic is VIM, IMP, and NDM resistant to due to Metallo--lactamases (MBLs)?
What is the main characteristic of Class A Carbapenemases like KPC?
What is the main characteristic of Class A Carbapenemases like KPC?
How does therapy for KPC-producing organisms typically involve?
How does therapy for KPC-producing organisms typically involve?
What is the main impact of Metallo--lactamases (MBLs) on patient mortality?
What is the main impact of Metallo--lactamases (MBLs) on patient mortality?
Where was the New Delhi Metallo--lactamase (NDM) first identified?
Where was the New Delhi Metallo--lactamase (NDM) first identified?
Why are undetected reservoirs of ESBLs in certain organisms concerning?
Why are undetected reservoirs of ESBLs in certain organisms concerning?
What is the main reason why patients with CTX-M ESBLs have a higher risk of being affected when traveling?
What is the main reason why patients with CTX-M ESBLs have a higher risk of being affected when traveling?
Why are ESBL-producing Enterobacteriaceae a concern beyond resistance to -lactams?
Why are ESBL-producing Enterobacteriaceae a concern beyond resistance to -lactams?
What is a characteristic of AmpC -lactamases that differentiates them from ESBLs?
What is a characteristic of AmpC -lactamases that differentiates them from ESBLs?
Which antibiotic class shows the highest activity against ESBL-producing Enterobacteriaceae?
Which antibiotic class shows the highest activity against ESBL-producing Enterobacteriaceae?
What distinguishes derepressed mutants from wild-type organisms in terms of antibiotic resistance?
What distinguishes derepressed mutants from wild-type organisms in terms of antibiotic resistance?
Which antibiotic type can induce AmpC enzymes in bacteria?
Which antibiotic type can induce AmpC enzymes in bacteria?
What is the significance of the promoter mutations regarding AmpC expression in bacteria?
What is the significance of the promoter mutations regarding AmpC expression in bacteria?
