4 Antimicrobial Stewardship & Response

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Questions and Answers

Which of the following strategies represents the most effective initial step for a veterinary practice aiming to implement an antimicrobial stewardship program, according to the AVMA guidelines?

  • Mandating routine antibiotic susceptibility testing for all bacterial infections.
  • Immediately ceasing the use of all compounded antimicrobial medications to ensure quality.
  • Establishing a designated 'antimicrobial stewardship team leader' to champion and coordinate efforts. (correct)
  • Implementing a blanket policy of delayed prescribing for all suspected upper respiratory infections.

Considering the principles of antimicrobial stewardship, which preventative healthcare measure would have the MOST significant impact on reducing the overall need for antibiotic use in a companion animal practice?

  • Routinely updating and strictly adhering to comprehensive vaccine and biosecurity protocols. (correct)
  • Implementing mandatory quarterly deworming protocols for all canine patients.
  • Promoting year-round flea and tick prevention to minimize dermatological infections.
  • Offering annual dental prophylaxis to all geriatric patients.

A client declines recommended diagnostic testing for their dog presenting with chronic cough, citing financial constraints. Which communication strategy would be MOST effective in encouraging diagnostic investigation while adhering to antimicrobial stewardship principles?

  • Immediately prescribe a broad-spectrum antibiotic to address potential bacterial involvement and satisfy client expectation.
  • Emphasize the potential long-term cost savings of accurate diagnosis and targeted treatment compared to empirical antibiotic use and potential treatment failures. (correct)
  • Offer a discounted rate on a compounded antibiotic as a more affordable treatment option, circumventing the need for diagnostics.
  • Suggest delaying treatment and re-evaluating in two weeks if the cough persists, without further diagnostic discussion.

In a canine patient diagnosed with a localized skin abscess, which of the following treatment approaches is MOST consistent with judicious antibiotic use?

<p>Performing surgical drainage and lavage of the abscess, reserving systemic antibiotics for cases showing systemic signs or cellulitis. (B)</p> Signup and view all the answers

Considering the pharmacokinetic and pharmacodynamic principles of antibiotic therapy, which diagnostic test is MOST crucial in guiding initial antibiotic selection for a canine patient with a suspected urinary tract infection?

<p>Urinalysis with microscopic sediment examination to guide empirical therapy while awaiting culture results. (D)</p> Signup and view all the answers

For which of the following clinical scenarios in a feline patient would 'delayed prescribing' of antibiotics be MOST appropriate as a judicious use strategy?

<p>A young cat presenting with acute, uncomplicated lower urinary tract signs (dysuria, pollakiuria) of less than 24 hours duration. (A)</p> Signup and view all the answers

Based on recent surveys of antimicrobial prescribing patterns in veterinary medicine, which of the following carbapenem antibiotics is considered MOST critical to avoid in routine veterinary practice due to its importance in human medicine and the risk of resistance development?

<p>Meropenem (C)</p> Signup and view all the answers

What is the PRIMARY legal concern regarding the 'other' category of compounded antibiotics, as contrasted with legal compounding practices?

<p>Unpredictable quality control and potential deviations from labeled potency and purity due to the bypassing of FDA approval processes. (D)</p> Signup and view all the answers

Which of the following statements accurately differentiates legally compounded antibiotics from 'other' compounded antibiotics in veterinary medicine?

<p>Legally compounded antibiotics are derived from FDA-approved drugs and reformulated for individual patients, while 'other' compounded antibiotics are made from bulk drug chemicals. (A)</p> Signup and view all the answers

Why are generic antibiotics considered a more ethically sound choice than 'other' compounded antibiotics for routine veterinary use, assuming comparable efficacy and availability?

<p>Generic antibiotics undergo bioequivalence testing and meet FDA quality standards, ensuring consistent quality and safety, unlike 'other' compounded drugs. (A)</p> Signup and view all the answers

In the context of antimicrobial stewardship, 'evidence-based medicine' primarily emphasizes which of the following approaches to clinical decision-making?

<p>Integrating the best available research evidence with clinical expertise and patient-specific factors. (A)</p> Signup and view all the answers

Which aspect of antimicrobial susceptibility breakpoints poses the GREATEST challenge for veterinarians in applying evidence-based medicine to antibiotic selection?

<p>Extrapolation from human breakpoints and limited veterinary-specific data necessitate cautious interpretation and clinical correlation. (A)</p> Signup and view all the answers

According to the AVMA's 'do's and don'ts' of antimicrobial therapy, what is the MOST appropriate initial diagnostic step in managing a canine patient with suspected pyoderma?

<p>Cytologic evaluation of skin lesions to confirm bacterial involvement and guide initial therapy. (C)</p> Signup and view all the answers

In feline lower urinary tract disease (FLUTD), which of the following scenarios would MOST strongly warrant antimicrobial therapy based on current antimicrobial stewardship guidelines?

<p>Mature cat (&gt;10 years old) with lower urinary tract signs and documented bacterial urinary tract infection confirmed by quantitative culture. (D)</p> Signup and view all the answers

For a canine patient diagnosed with acute, uncomplicated upper respiratory tract disease (URTD), what is the MOST appropriate therapeutic recommendation in alignment with antimicrobial stewardship?

<p>Providing supportive care and symptomatic treatment, as antimicrobials are generally unnecessary for uncomplicated URTD. (C)</p> Signup and view all the answers

Which of the following behavioral influences is LEAST likely to contribute to inappropriate antimicrobial prescribing in veterinary practice?

<p>Veterinarian's strong understanding of current antimicrobial resistance patterns and stewardship guidelines. (B)</p> Signup and view all the answers

In a 3-year-old male cat presenting with recurrent episodes of urinating outside the litter box, with client history suggesting improvement with previous antibiotic courses, what is the estimated probability of a bacterial urinary tract infection being the underlying cause?

<p>&lt;5% (D)</p> Signup and view all the answers

According to recent consumer affairs data and veterinary insurance claims, what is the MOST common claim category for feline insurance, potentially reflecting a tendency towards over-diagnosis or over-treatment in veterinary medicine?

<p>Urinary tract infections (A)</p> Signup and view all the answers

Reviewing the provided table of antimicrobial prescribing for feline UTIs, which antimicrobial class is MOST frequently prescribed for both nonrecurrent and recurrent feline UTIs, despite guidelines advocating for more judicious use?

<p>Penicillins (B)</p> Signup and view all the answers

What is the PRIMARY mechanism by which inappropriate or excessive antibiotic use contributes to the development and propagation of antimicrobial resistance?

<p>Creating 'selection pressure' that favors the survival and proliferation of resistant bacteria while eliminating susceptible populations. (D)</p> Signup and view all the answers

According to the study on the effect of cefovecin on fecal flora in dogs, what was the MOST significant long-term consequence observed after cefovecin administration in healthy dogs?

<p>Significant and prolonged increase in the proportion of antibiotic-resistant <em>E. coli</em> and enterococci in the fecal flora. (B)</p> Signup and view all the answers

In a 6-year-old dog presenting with acute colitis, and the owner expecting metronidazole, what is the MOST compelling evidence-based rationale for considering nutritional management as a superior first-line treatment?

<p>Nutritional management has been shown in randomized controlled trials to result in faster clinical recovery compared to metronidazole in acute colitis cases. (D)</p> Signup and view all the answers

What is the MOST significant 'baggage' associated with antimicrobial use, even when clinically indicated, that necessitates judicious prescribing practices?

<p>Adverse effects on the patient's microbiome and contribution to the broader problem of antimicrobial resistance. (B)</p> Signup and view all the answers

In a 12-year-old diabetic dog presenting for a routine recheck, an incidental urine culture reveals Klebsiella pneumoniae with multi-drug resistance (MDR), but the dog shows no clinical signs of urinary tract infection. What is the MOST appropriate course of action regarding antibiotic therapy?

<p>Withhold antibiotic treatment as the dog is clinically asymptomatic, and treatment of subclinical bacteriuria is generally discouraged. (D)</p> Signup and view all the answers

What is the PRIMARY clinical significance of identifying a carbapenem-resistant Enterobacterales (CRE) organism in a veterinary patient's culture?

<p>CRE infections are extremely difficult to treat due to resistance to multiple antibiotic classes, including carbapenems, and pose a public health risk. (A)</p> Signup and view all the answers

According to the provided antibiotic susceptibility pattern for Klebsiella pneumoniae, which antibiotic would be considered susceptible based on the interpretation and MIC values?

<p>Doxycycline (A)</p> Signup and view all the answers

What is the MOST critical infection control measure to implement when managing a hospitalized patient diagnosed with a carbapenem-resistant Enterobacterales (CRE) infection?

<p>Strict isolation of the patient, meticulous hand hygiene, and enhanced environmental cleaning protocols. (A)</p> Signup and view all the answers

When communicating with clients about a pet diagnosed with a CRE infection, what is the MOST important aspect to emphasize regarding public health concerns?

<p>The importance of hygiene precautions, such as hand washing, to minimize potential spread of CRE, especially to vulnerable individuals. (D)</p> Signup and view all the answers

Which of the following bacterial species is explicitly listed as an 'Organism to be on Lookout for...' in the context of emerging antimicrobial resistance threats in veterinary medicine?

<p><em>Corynebacterium ulcerans</em> (A)</p> Signup and view all the answers

What is the rationale behind recommending 'zoonoses sign on cage door' for patients with CRE infections in a veterinary hospital?

<p>To alert veterinary staff to the highly contagious nature of CRE and the need for strict barrier precautions to protect themselves and other patients. (A)</p> Signup and view all the answers

In managing a canine patient with a CRE urinary tract infection, which of the following topical antiseptic or antimicrobial agents would be MOST appropriate to consider for adjunctive therapy of skin or wound infections, if present, aligning with antimicrobial stewardship principles?

<p>Topical silver sulfadiazine or chlorhexidine (A)</p> Signup and view all the answers

For a veterinary practice aiming to enhance its antimicrobial stewardship program, which of the following resources would provide the MOST comprehensive and evidence-based guidelines for developing and implementing a CRE plan and response resource?

<p>PennVet CREATE CRE Plan and Response Resource. (A)</p> Signup and view all the answers

Which of the following strategies is LEAST effective in minimizing the spread of CRE within a veterinary hospital setting?

<p>Using shared equipment (e.g., stethoscopes) between CRE-positive and CRE-negative patients after disinfection. (C)</p> Signup and view all the answers

What is the recommended duration for advising clients to avoid taking their CRE-positive pet to public spaces to minimize potential environmental contamination and spread?

<p>At least 6 months after diagnosis, or until repeat cultures are negative. (A)</p> Signup and view all the answers

In the context of antimicrobial stewardship and alarming culture reports, what is the MOST significant 'alarm' associated with a culture report indicating 'NI' (non-interpretable) for multiple antibiotic classes, including critical agents?

<p>The organism is likely intrinsically resistant to those antibiotic classes, indicating potential multi-drug resistance. (C)</p> Signup and view all the answers

What is the MOST appropriate term to describe Enterobacterales exhibiting resistance to carbapenems, a class of 'last-resort' antibiotics, reflecting a critical public health threat?

<p>Carbapenem-resistant Enterobacterales (CRE) (A)</p> Signup and view all the answers

Which of the following best describes the role of 'Imipenem' in the context of identifying carbapenem resistance in Enterobacterales?

<p>Resistance to Imipenem is a key marker used to identify carbapenem-resistant Enterobacterales (CRE). (A)</p> Signup and view all the answers

What is the MOST accurate interpretation of the acronym 'CRO' in the context of antimicrobial resistance and alarming culture reports?

<p>Carbapenem-Resistant Organism (B)</p> Signup and view all the answers

Which of the following statements BEST describes the relative virulence and pathogenicity of antimicrobial-resistant (AMR) organisms compared to their susceptible counterparts?

<p>AMR organisms are not intrinsically more likely to cause disease than susceptible counterparts; virulence depends more on species and host factors. (C)</p> Signup and view all the answers

In the context of antimicrobial selection, what is the MOST critical factor to consider beyond antimicrobial susceptibility when a pet owner expresses financial constraints regarding diagnostic testing?

<p>Prioritizing diagnostics that offer the highest probability of identifying a treatable bacterial infection. (B)</p> Signup and view all the answers

When a veterinary practice aims to reduce inappropriate antimicrobial use, which approach would MOST effectively address the 'client expectations' behavioral influence?

<p>Proactively communicating the rationale for diagnostic testing and antimicrobial use guidelines. (B)</p> Signup and view all the answers

In managing a patient with a suspected bacterial infection, which diagnostic approach BEST supports antimicrobial stewardship principles by guiding targeted therapy?

<p>Employing in-house cytology to guide initial antimicrobial selection pending culture results. (C)</p> Signup and view all the answers

Considering the principles of antimicrobial stewardship, which action would MOST effectively address the potential overuse of antibiotics in managing uncomplicated upper respiratory infections within a multi-doctor veterinary practice?

<p>Establishing standardized treatment protocols emphasizing supportive care and delayed prescribing for uncomplicated cases. (B)</p> Signup and view all the answers

When evaluating the potential use of compounded antimicrobials, what is the PRIMARY ethical consideration that aligns with evidence-based veterinary medicine?

<p>The potential for unpredictable bioavailability and efficacy due to lack of regulatory oversight. (C)</p> Signup and view all the answers

When educating veterinary clients about antimicrobial resistance, which explanation BEST conveys the public health importance of responsible antimicrobial use?

<p>The overuse of antimicrobials can lead to the development of 'superbugs' that are difficult or impossible to treat in both animals and humans. (D)</p> Signup and view all the answers

In a scenario where a dog is diagnosed with a carbapenem-resistant Enterobacterales (CRE) infection, what is the MOST relevant piece of information to convey to the pet owner regarding infection control measures at home?

<p>The necessity of rigorous hand hygiene and preventing the pet from licking open wounds or mucosal surfaces of family members. (C)</p> Signup and view all the answers

In a veterinary teaching hospital, what is the MOST effective strategy to minimize the risk of CRE transmission between patients?

<p>Cohorting CRE-positive patients in a designated isolation ward with dedicated staff and equipment. (B)</p> Signup and view all the answers

When reviewing an antimicrobial susceptibility report, which result should MOST strongly prompt a re-evaluation of the planned treatment and consideration of alternative agents or a consultation with a specialist?

<p>Non-interpretive (NI) results for multiple classes of antimicrobials, including those considered 'last resort' options. (B)</p> Signup and view all the answers

What is the MOST important implication of identifying a carbapenem-resistant organism (CRO) in a companion animal, beyond its direct impact on the patient's health?

<p>CROs represent a significant threat to public health due to their potential for transmission and limited treatment options. (A)</p> Signup and view all the answers

Flashcards

Antimicrobial Stewardship

Actions taken by veterinarians to maintain the effectiveness and availability of antimicrobials.

Antimicrobial Prescribing

Actions to judiciously use antimicrobials, including appropriate selection and duration.

AVMA Stewardship Principles

Commit to stewardship, prevent common diseases, judiciously use antimicrobials, evaluate use, and build expertise.

Prevent Common Diseases

Minimizing disease through vaccines, infection control, good nutrition, and disease management.

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Diagnostic testing for infection

Involves costs and diagnostics can be done in-house.

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Source of Infection Removal

Addressing underlying issues, like removing foreign bodies or managing diseases, rather than relying solely on antibiotics.

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Using Antibiotics Judiciously

Using judgement in using antibiotics

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Targeted Initial Therapy

Targeting antimicrobial therapy based on all available information.

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Evaluate Use Antibiotics

Avoided because they are important for treating resistant human infections

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Legal compounding

Pharmacist takes FDA approved pill and reformulates it into a smaller pill

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Other compounding

These purchase drug chemicals in bulk and bypass FDA approval process

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Cheaper generic antibiotics

Use cheaper generic antibiotics that are FDA approved.

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Build Expertise

Updating knowledge, breakpoints, and conducting research.

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Behavioral Factors in Prescribing

Client expectations, peer pressure, and medical knowledge can greatly influence prescribing habits.

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Prescribing Antibiotics

First generation antibiotics should be prescribed when needed.

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Antibiotics Selection Pressure

Normal flora die off

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CRE

There are organisms to be on the look out for

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CRE and Spread

Spreadsilently through hospitals and set up reservoirs

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Study Notes

  • Presents an overview of antimicrobial stewardship and response, focusing on clinical pharmacology.
  • Lists the goals of antimicrobial stewardship which involves components of antimicrobial stewardship, prescribing, and recognizing alarming culture reports

What is Stewardship?

  • Stewardship, as defined by the AVMA, includes the actions veterinarians take individually and as a profession to preserve the effectiveness and availability of antimicrobial drugs.
  • Responsible antimicrobial use involves strategies, addressing the necessity, selection, and appropriate use of antimicrobials in veterinary practice.

AVMA Core Principles for Stewardship

  • Prioritize commitment to stewardship, disease prevention, judicious antimicrobial selection, evaluation of drug use, and expertise development.

Committing to Stewardship

  • Begin with achievable goals and cultivate support from the practice owner, manager, and team.
  • Emphasize the importance of team leadership in promoting motivation towards common goals.

Preventing Common Diseases

  • Good preventative medicine and healthcare can help minimize the need for antibiotics.
  • Strategies include regularly reviewing and updating vaccine and infection control protocols.
  • Client education on husbandry and nutrition helps prevent diseases
  • Managing existing conditions like diabetes in older cats minimizes the risk of secondary infections.

Using Antibiotics Judiciously

  • The key is to first do a diagnosis to figure out how to best treat.
  • Diagnostic testing is often expensive, with pet owners paying out of pocket.
  • Only 2-4% of pet owners have insurance, and not everyone can afford tests.
  • 20 out of 25 pet owners are receptive to tests.

Diagnostic Solutions

  • It is important to make diagnostic recommendations
  • Clients are receptive if solid reasoning is presented
  • Develop a list of differential diagnoses
  • Procedures like tracheal washes are available in most private practices

Treatment Solutions

  • Removing sources of infection by lancing abscesses, and removing infected orthopedic implants.
  • Managing underlying diseases will give the pet's immune system a chance to fight

Important Reminders Regarding Bacteria

  • Bacteria are opportunistic, thriving in the presence of anatomical abnormalities, foreign bodies, or immunosuppression.
  • Addressing anatomical abnormalities, foreign bodies, or immunosuppression helps to eliminate bacteria.
  • Bacteria does not disappear until the underlying problem is resolved
  • Using fancy antibiotics before fixing the issue only makes them more resistant

Determining Appropriate Use

  • Target initial therapy based on all known information.
  • Solutions include looking at urine sediment for shape of bacteria, and Gram stain, and testing for wounds with cytology.

Tools for Judicious Use of Antibiotics

  • Some patients do not need antibiotic for diseases such as upper respiratory cat with viral infection, young cat with bladder infection, and dogs with acute diarrhea.
  • Non-antibiotic prescriptions and delayed prescriptions are methods to treat without the use of antibiotics

Evaluating Antibiotics

  • The amount of medications prescribed is important
  • Some medications are avoided because they are more important to human health
  • Imipenem is prescribed 0% of the time
  • Pip-tazo is prescribed 0% of the time
  • Meropenem is prescribed 7% of the time
  • Ceftazidime is prescribed 11% of the time

Compounded Antibiotics

  • Compounding pharmacies purchase drug chemicals in bulk
  • Compounded Antibiotics formulate pills, tablets, chews, and liquid medications
  • Compounded Antibiotics add various flavors
  • Compounded Antibiotics have unpredictable quality control because they bypass FDA processes
  • Compounded Antibiotics are advertised and sold in bulk to veterinarians

Generic Antibiotics

  • Generic antibiotics are FDA approved
  • They undergo testing and must have the same qualities of brand name antibiotics

Educating and Building Expertise

  • There are gaps in knowledge and needed research
  • Breakpoints for susceptibility and much extrapolation is needed
  • Duration studies and optimal dosing studies are needed
  • It is important for vets to stay up to date

Prescribing Antimicrobials

  • The key questions include ensuring there is an infection, understanding the root cause, assessing the need for antibiotics, and selecting the best option.

Behavioral Influences

  • There are many behavioral influences in prescribing antibiotics, such as client expectations, peer preassure, time of day, and fear of medical failure.
  • It is important to build trust with clients to help with these concerns

Common Challenges for Antibiotic Approval

  • A client might bring a cat in that is urinating outside the box
  • The client might state that this happened before and wants a Convenia shot
  • It is important to see what factors lead to this
  • It is important to determine what diagnostic tests should be recommended and whether antibiotics are indicated

Common Scenarios

  • Veterinarians may encounter clients who expect antibiotics for their pets, such as a 6-year-old dog presenting with actue colitis.

Responsible Use of Antibiotics

  • In this scenario, many might expect metronidazole, or be always prescribed metronidazole
  • When they are needed, antibiotics can be lifesaving but come with baggage, such as challenges administering, compliance issues, adverse effects, impacts on the GI microbiome, and cost.

Recognizing and Responding to Alarming Cultures

  • A 12 year old hound dog is presented and is a recheck for diabetes
  • routine work is ordered for her
  • It is important to determine if antibiotics and treatment are needed

MDR Management

  • The isolation of MDR Species should not affect decision making on whether to treat subclinical bacteria
  • AMR are not more likely to cause disease than their susceptible counterparts

Handling CREs

  • CRE is among the greatest threat to animal and human health and is impossible to treat
  • This sign indicates that staff is in contact with a patient
  • Steps should be taken to protect them

Responding to CREs

  • Flier to help educate vets and staff -Important to have trained staff that minimize people involved

Client Discussions

  • Clients need to know it is a public health concern and it can be very hard to treat in pets and people
  • Precautions are need to avoid spread
  • CRE is reportable in people in Kansas, but not animals.
  • It is important to provide client resources

Home Care

  • A copy of the treatment plan is sent to the primary vet.
  • They need to recontact primary vets with treatment plan information
  • There is a flier for the family to follow basic procedures

Organisms to be on Lookout

  • Include CRE, carbapenem-resistant Pseudomonas, MRSA/MRSP, Corynebacterium ulcerans, Candida auris, and MDR Enterococcus.

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