Podcast
Questions and Answers
Which of the following strategies represents the most effective initial step for a veterinary practice aiming to implement an antimicrobial stewardship program, according to the AVMA guidelines?
Which of the following strategies represents the most effective initial step for a veterinary practice aiming to implement an antimicrobial stewardship program, according to the AVMA guidelines?
- Mandating routine antibiotic susceptibility testing for all bacterial infections.
- Immediately ceasing the use of all compounded antimicrobial medications to ensure quality.
- Establishing a designated 'antimicrobial stewardship team leader' to champion and coordinate efforts. (correct)
- Implementing a blanket policy of delayed prescribing for all suspected upper respiratory infections.
Considering the principles of antimicrobial stewardship, which preventative healthcare measure would have the MOST significant impact on reducing the overall need for antibiotic use in a companion animal practice?
Considering the principles of antimicrobial stewardship, which preventative healthcare measure would have the MOST significant impact on reducing the overall need for antibiotic use in a companion animal practice?
- Routinely updating and strictly adhering to comprehensive vaccine and biosecurity protocols. (correct)
- Implementing mandatory quarterly deworming protocols for all canine patients.
- Promoting year-round flea and tick prevention to minimize dermatological infections.
- Offering annual dental prophylaxis to all geriatric patients.
A client declines recommended diagnostic testing for their dog presenting with chronic cough, citing financial constraints. Which communication strategy would be MOST effective in encouraging diagnostic investigation while adhering to antimicrobial stewardship principles?
A client declines recommended diagnostic testing for their dog presenting with chronic cough, citing financial constraints. Which communication strategy would be MOST effective in encouraging diagnostic investigation while adhering to antimicrobial stewardship principles?
- Immediately prescribe a broad-spectrum antibiotic to address potential bacterial involvement and satisfy client expectation.
- Emphasize the potential long-term cost savings of accurate diagnosis and targeted treatment compared to empirical antibiotic use and potential treatment failures. (correct)
- Offer a discounted rate on a compounded antibiotic as a more affordable treatment option, circumventing the need for diagnostics.
- Suggest delaying treatment and re-evaluating in two weeks if the cough persists, without further diagnostic discussion.
In a canine patient diagnosed with a localized skin abscess, which of the following treatment approaches is MOST consistent with judicious antibiotic use?
In a canine patient diagnosed with a localized skin abscess, which of the following treatment approaches is MOST consistent with judicious antibiotic use?
Considering the pharmacokinetic and pharmacodynamic principles of antibiotic therapy, which diagnostic test is MOST crucial in guiding initial antibiotic selection for a canine patient with a suspected urinary tract infection?
Considering the pharmacokinetic and pharmacodynamic principles of antibiotic therapy, which diagnostic test is MOST crucial in guiding initial antibiotic selection for a canine patient with a suspected urinary tract infection?
For which of the following clinical scenarios in a feline patient would 'delayed prescribing' of antibiotics be MOST appropriate as a judicious use strategy?
For which of the following clinical scenarios in a feline patient would 'delayed prescribing' of antibiotics be MOST appropriate as a judicious use strategy?
Based on recent surveys of antimicrobial prescribing patterns in veterinary medicine, which of the following carbapenem antibiotics is considered MOST critical to avoid in routine veterinary practice due to its importance in human medicine and the risk of resistance development?
Based on recent surveys of antimicrobial prescribing patterns in veterinary medicine, which of the following carbapenem antibiotics is considered MOST critical to avoid in routine veterinary practice due to its importance in human medicine and the risk of resistance development?
What is the PRIMARY legal concern regarding the 'other' category of compounded antibiotics, as contrasted with legal compounding practices?
What is the PRIMARY legal concern regarding the 'other' category of compounded antibiotics, as contrasted with legal compounding practices?
Which of the following statements accurately differentiates legally compounded antibiotics from 'other' compounded antibiotics in veterinary medicine?
Which of the following statements accurately differentiates legally compounded antibiotics from 'other' compounded antibiotics in veterinary medicine?
Why are generic antibiotics considered a more ethically sound choice than 'other' compounded antibiotics for routine veterinary use, assuming comparable efficacy and availability?
Why are generic antibiotics considered a more ethically sound choice than 'other' compounded antibiotics for routine veterinary use, assuming comparable efficacy and availability?
In the context of antimicrobial stewardship, 'evidence-based medicine' primarily emphasizes which of the following approaches to clinical decision-making?
In the context of antimicrobial stewardship, 'evidence-based medicine' primarily emphasizes which of the following approaches to clinical decision-making?
Which aspect of antimicrobial susceptibility breakpoints poses the GREATEST challenge for veterinarians in applying evidence-based medicine to antibiotic selection?
Which aspect of antimicrobial susceptibility breakpoints poses the GREATEST challenge for veterinarians in applying evidence-based medicine to antibiotic selection?
According to the AVMA's 'do's and don'ts' of antimicrobial therapy, what is the MOST appropriate initial diagnostic step in managing a canine patient with suspected pyoderma?
According to the AVMA's 'do's and don'ts' of antimicrobial therapy, what is the MOST appropriate initial diagnostic step in managing a canine patient with suspected pyoderma?
In feline lower urinary tract disease (FLUTD), which of the following scenarios would MOST strongly warrant antimicrobial therapy based on current antimicrobial stewardship guidelines?
In feline lower urinary tract disease (FLUTD), which of the following scenarios would MOST strongly warrant antimicrobial therapy based on current antimicrobial stewardship guidelines?
For a canine patient diagnosed with acute, uncomplicated upper respiratory tract disease (URTD), what is the MOST appropriate therapeutic recommendation in alignment with antimicrobial stewardship?
For a canine patient diagnosed with acute, uncomplicated upper respiratory tract disease (URTD), what is the MOST appropriate therapeutic recommendation in alignment with antimicrobial stewardship?
Which of the following behavioral influences is LEAST likely to contribute to inappropriate antimicrobial prescribing in veterinary practice?
Which of the following behavioral influences is LEAST likely to contribute to inappropriate antimicrobial prescribing in veterinary practice?
In a 3-year-old male cat presenting with recurrent episodes of urinating outside the litter box, with client history suggesting improvement with previous antibiotic courses, what is the estimated probability of a bacterial urinary tract infection being the underlying cause?
In a 3-year-old male cat presenting with recurrent episodes of urinating outside the litter box, with client history suggesting improvement with previous antibiotic courses, what is the estimated probability of a bacterial urinary tract infection being the underlying cause?
According to recent consumer affairs data and veterinary insurance claims, what is the MOST common claim category for feline insurance, potentially reflecting a tendency towards over-diagnosis or over-treatment in veterinary medicine?
According to recent consumer affairs data and veterinary insurance claims, what is the MOST common claim category for feline insurance, potentially reflecting a tendency towards over-diagnosis or over-treatment in veterinary medicine?
Reviewing the provided table of antimicrobial prescribing for feline UTIs, which antimicrobial class is MOST frequently prescribed for both nonrecurrent and recurrent feline UTIs, despite guidelines advocating for more judicious use?
Reviewing the provided table of antimicrobial prescribing for feline UTIs, which antimicrobial class is MOST frequently prescribed for both nonrecurrent and recurrent feline UTIs, despite guidelines advocating for more judicious use?
What is the PRIMARY mechanism by which inappropriate or excessive antibiotic use contributes to the development and propagation of antimicrobial resistance?
What is the PRIMARY mechanism by which inappropriate or excessive antibiotic use contributes to the development and propagation of antimicrobial resistance?
According to the study on the effect of cefovecin on fecal flora in dogs, what was the MOST significant long-term consequence observed after cefovecin administration in healthy dogs?
According to the study on the effect of cefovecin on fecal flora in dogs, what was the MOST significant long-term consequence observed after cefovecin administration in healthy dogs?
In a 6-year-old dog presenting with acute colitis, and the owner expecting metronidazole, what is the MOST compelling evidence-based rationale for considering nutritional management as a superior first-line treatment?
In a 6-year-old dog presenting with acute colitis, and the owner expecting metronidazole, what is the MOST compelling evidence-based rationale for considering nutritional management as a superior first-line treatment?
What is the MOST significant 'baggage' associated with antimicrobial use, even when clinically indicated, that necessitates judicious prescribing practices?
What is the MOST significant 'baggage' associated with antimicrobial use, even when clinically indicated, that necessitates judicious prescribing practices?
In a 12-year-old diabetic dog presenting for a routine recheck, an incidental urine culture reveals Klebsiella pneumoniae with multi-drug resistance (MDR), but the dog shows no clinical signs of urinary tract infection. What is the MOST appropriate course of action regarding antibiotic therapy?
In a 12-year-old diabetic dog presenting for a routine recheck, an incidental urine culture reveals Klebsiella pneumoniae with multi-drug resistance (MDR), but the dog shows no clinical signs of urinary tract infection. What is the MOST appropriate course of action regarding antibiotic therapy?
What is the PRIMARY clinical significance of identifying a carbapenem-resistant Enterobacterales (CRE) organism in a veterinary patient's culture?
What is the PRIMARY clinical significance of identifying a carbapenem-resistant Enterobacterales (CRE) organism in a veterinary patient's culture?
According to the provided antibiotic susceptibility pattern for Klebsiella pneumoniae, which antibiotic would be considered susceptible based on the interpretation and MIC values?
According to the provided antibiotic susceptibility pattern for Klebsiella pneumoniae, which antibiotic would be considered susceptible based on the interpretation and MIC values?
What is the MOST critical infection control measure to implement when managing a hospitalized patient diagnosed with a carbapenem-resistant Enterobacterales (CRE) infection?
What is the MOST critical infection control measure to implement when managing a hospitalized patient diagnosed with a carbapenem-resistant Enterobacterales (CRE) infection?
When communicating with clients about a pet diagnosed with a CRE infection, what is the MOST important aspect to emphasize regarding public health concerns?
When communicating with clients about a pet diagnosed with a CRE infection, what is the MOST important aspect to emphasize regarding public health concerns?
Which of the following bacterial species is explicitly listed as an 'Organism to be on Lookout for...' in the context of emerging antimicrobial resistance threats in veterinary medicine?
Which of the following bacterial species is explicitly listed as an 'Organism to be on Lookout for...' in the context of emerging antimicrobial resistance threats in veterinary medicine?
What is the rationale behind recommending 'zoonoses sign on cage door' for patients with CRE infections in a veterinary hospital?
What is the rationale behind recommending 'zoonoses sign on cage door' for patients with CRE infections in a veterinary hospital?
In managing a canine patient with a CRE urinary tract infection, which of the following topical antiseptic or antimicrobial agents would be MOST appropriate to consider for adjunctive therapy of skin or wound infections, if present, aligning with antimicrobial stewardship principles?
In managing a canine patient with a CRE urinary tract infection, which of the following topical antiseptic or antimicrobial agents would be MOST appropriate to consider for adjunctive therapy of skin or wound infections, if present, aligning with antimicrobial stewardship principles?
For a veterinary practice aiming to enhance its antimicrobial stewardship program, which of the following resources would provide the MOST comprehensive and evidence-based guidelines for developing and implementing a CRE plan and response resource?
For a veterinary practice aiming to enhance its antimicrobial stewardship program, which of the following resources would provide the MOST comprehensive and evidence-based guidelines for developing and implementing a CRE plan and response resource?
Which of the following strategies is LEAST effective in minimizing the spread of CRE within a veterinary hospital setting?
Which of the following strategies is LEAST effective in minimizing the spread of CRE within a veterinary hospital setting?
What is the recommended duration for advising clients to avoid taking their CRE-positive pet to public spaces to minimize potential environmental contamination and spread?
What is the recommended duration for advising clients to avoid taking their CRE-positive pet to public spaces to minimize potential environmental contamination and spread?
In the context of antimicrobial stewardship and alarming culture reports, what is the MOST significant 'alarm' associated with a culture report indicating 'NI' (non-interpretable) for multiple antibiotic classes, including critical agents?
In the context of antimicrobial stewardship and alarming culture reports, what is the MOST significant 'alarm' associated with a culture report indicating 'NI' (non-interpretable) for multiple antibiotic classes, including critical agents?
What is the MOST appropriate term to describe Enterobacterales exhibiting resistance to carbapenems, a class of 'last-resort' antibiotics, reflecting a critical public health threat?
What is the MOST appropriate term to describe Enterobacterales exhibiting resistance to carbapenems, a class of 'last-resort' antibiotics, reflecting a critical public health threat?
Which of the following best describes the role of 'Imipenem' in the context of identifying carbapenem resistance in Enterobacterales?
Which of the following best describes the role of 'Imipenem' in the context of identifying carbapenem resistance in Enterobacterales?
What is the MOST accurate interpretation of the acronym 'CRO' in the context of antimicrobial resistance and alarming culture reports?
What is the MOST accurate interpretation of the acronym 'CRO' in the context of antimicrobial resistance and alarming culture reports?
Which of the following statements BEST describes the relative virulence and pathogenicity of antimicrobial-resistant (AMR) organisms compared to their susceptible counterparts?
Which of the following statements BEST describes the relative virulence and pathogenicity of antimicrobial-resistant (AMR) organisms compared to their susceptible counterparts?
In the context of antimicrobial selection, what is the MOST critical factor to consider beyond antimicrobial susceptibility when a pet owner expresses financial constraints regarding diagnostic testing?
In the context of antimicrobial selection, what is the MOST critical factor to consider beyond antimicrobial susceptibility when a pet owner expresses financial constraints regarding diagnostic testing?
When a veterinary practice aims to reduce inappropriate antimicrobial use, which approach would MOST effectively address the 'client expectations' behavioral influence?
When a veterinary practice aims to reduce inappropriate antimicrobial use, which approach would MOST effectively address the 'client expectations' behavioral influence?
In managing a patient with a suspected bacterial infection, which diagnostic approach BEST supports antimicrobial stewardship principles by guiding targeted therapy?
In managing a patient with a suspected bacterial infection, which diagnostic approach BEST supports antimicrobial stewardship principles by guiding targeted therapy?
Considering the principles of antimicrobial stewardship, which action would MOST effectively address the potential overuse of antibiotics in managing uncomplicated upper respiratory infections within a multi-doctor veterinary practice?
Considering the principles of antimicrobial stewardship, which action would MOST effectively address the potential overuse of antibiotics in managing uncomplicated upper respiratory infections within a multi-doctor veterinary practice?
When evaluating the potential use of compounded antimicrobials, what is the PRIMARY ethical consideration that aligns with evidence-based veterinary medicine?
When evaluating the potential use of compounded antimicrobials, what is the PRIMARY ethical consideration that aligns with evidence-based veterinary medicine?
When educating veterinary clients about antimicrobial resistance, which explanation BEST conveys the public health importance of responsible antimicrobial use?
When educating veterinary clients about antimicrobial resistance, which explanation BEST conveys the public health importance of responsible antimicrobial use?
In a scenario where a dog is diagnosed with a carbapenem-resistant Enterobacterales (CRE) infection, what is the MOST relevant piece of information to convey to the pet owner regarding infection control measures at home?
In a scenario where a dog is diagnosed with a carbapenem-resistant Enterobacterales (CRE) infection, what is the MOST relevant piece of information to convey to the pet owner regarding infection control measures at home?
In a veterinary teaching hospital, what is the MOST effective strategy to minimize the risk of CRE transmission between patients?
In a veterinary teaching hospital, what is the MOST effective strategy to minimize the risk of CRE transmission between patients?
When reviewing an antimicrobial susceptibility report, which result should MOST strongly prompt a re-evaluation of the planned treatment and consideration of alternative agents or a consultation with a specialist?
When reviewing an antimicrobial susceptibility report, which result should MOST strongly prompt a re-evaluation of the planned treatment and consideration of alternative agents or a consultation with a specialist?
What is the MOST important implication of identifying a carbapenem-resistant organism (CRO) in a companion animal, beyond its direct impact on the patient's health?
What is the MOST important implication of identifying a carbapenem-resistant organism (CRO) in a companion animal, beyond its direct impact on the patient's health?
Flashcards
Antimicrobial Stewardship
Antimicrobial Stewardship
Actions taken by veterinarians to maintain the effectiveness and availability of antimicrobials.
Antimicrobial Prescribing
Antimicrobial Prescribing
Actions to judiciously use antimicrobials, including appropriate selection and duration.
AVMA Stewardship Principles
AVMA Stewardship Principles
Commit to stewardship, prevent common diseases, judiciously use antimicrobials, evaluate use, and build expertise.
Prevent Common Diseases
Prevent Common Diseases
Minimizing disease through vaccines, infection control, good nutrition, and disease management.
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Diagnostic testing for infection
Diagnostic testing for infection
Involves costs and diagnostics can be done in-house.
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Source of Infection Removal
Source of Infection Removal
Addressing underlying issues, like removing foreign bodies or managing diseases, rather than relying solely on antibiotics.
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Using Antibiotics Judiciously
Using Antibiotics Judiciously
Using judgement in using antibiotics
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Targeted Initial Therapy
Targeted Initial Therapy
Targeting antimicrobial therapy based on all available information.
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Evaluate Use Antibiotics
Evaluate Use Antibiotics
Avoided because they are important for treating resistant human infections
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Legal compounding
Legal compounding
Pharmacist takes FDA approved pill and reformulates it into a smaller pill
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Other compounding
Other compounding
These purchase drug chemicals in bulk and bypass FDA approval process
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Cheaper generic antibiotics
Cheaper generic antibiotics
Use cheaper generic antibiotics that are FDA approved.
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Build Expertise
Build Expertise
Updating knowledge, breakpoints, and conducting research.
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Behavioral Factors in Prescribing
Behavioral Factors in Prescribing
Client expectations, peer pressure, and medical knowledge can greatly influence prescribing habits.
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Prescribing Antibiotics
Prescribing Antibiotics
First generation antibiotics should be prescribed when needed.
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Antibiotics Selection Pressure
Antibiotics Selection Pressure
Normal flora die off
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CRE
CRE
There are organisms to be on the look out for
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CRE and Spread
CRE and Spread
Spreadsilently through hospitals and set up reservoirs
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- Presents an overview of antimicrobial stewardship and response, focusing on clinical pharmacology.
- Lists the goals of antimicrobial stewardship which involves components of antimicrobial stewardship, prescribing, and recognizing alarming culture reports
What is Stewardship?
- Stewardship, as defined by the AVMA, includes the actions veterinarians take individually and as a profession to preserve the effectiveness and availability of antimicrobial drugs.
- Responsible antimicrobial use involves strategies, addressing the necessity, selection, and appropriate use of antimicrobials in veterinary practice.
AVMA Core Principles for Stewardship
- Prioritize commitment to stewardship, disease prevention, judicious antimicrobial selection, evaluation of drug use, and expertise development.
Committing to Stewardship
- Begin with achievable goals and cultivate support from the practice owner, manager, and team.
- Emphasize the importance of team leadership in promoting motivation towards common goals.
Preventing Common Diseases
- Good preventative medicine and healthcare can help minimize the need for antibiotics.
- Strategies include regularly reviewing and updating vaccine and infection control protocols.
- Client education on husbandry and nutrition helps prevent diseases
- Managing existing conditions like diabetes in older cats minimizes the risk of secondary infections.
Using Antibiotics Judiciously
- The key is to first do a diagnosis to figure out how to best treat.
- Diagnostic testing is often expensive, with pet owners paying out of pocket.
- Only 2-4% of pet owners have insurance, and not everyone can afford tests.
- 20 out of 25 pet owners are receptive to tests.
Diagnostic Solutions
- It is important to make diagnostic recommendations
- Clients are receptive if solid reasoning is presented
- Develop a list of differential diagnoses
- Procedures like tracheal washes are available in most private practices
Treatment Solutions
- Removing sources of infection by lancing abscesses, and removing infected orthopedic implants.
- Managing underlying diseases will give the pet's immune system a chance to fight
Important Reminders Regarding Bacteria
- Bacteria are opportunistic, thriving in the presence of anatomical abnormalities, foreign bodies, or immunosuppression.
- Addressing anatomical abnormalities, foreign bodies, or immunosuppression helps to eliminate bacteria.
- Bacteria does not disappear until the underlying problem is resolved
- Using fancy antibiotics before fixing the issue only makes them more resistant
Determining Appropriate Use
- Target initial therapy based on all known information.
- Solutions include looking at urine sediment for shape of bacteria, and Gram stain, and testing for wounds with cytology.
Tools for Judicious Use of Antibiotics
- Some patients do not need antibiotic for diseases such as upper respiratory cat with viral infection, young cat with bladder infection, and dogs with acute diarrhea.
- Non-antibiotic prescriptions and delayed prescriptions are methods to treat without the use of antibiotics
Evaluating Antibiotics
- The amount of medications prescribed is important
- Some medications are avoided because they are more important to human health
- Imipenem is prescribed 0% of the time
- Pip-tazo is prescribed 0% of the time
- Meropenem is prescribed 7% of the time
- Ceftazidime is prescribed 11% of the time
Compounded Antibiotics
- Compounding pharmacies purchase drug chemicals in bulk
- Compounded Antibiotics formulate pills, tablets, chews, and liquid medications
- Compounded Antibiotics add various flavors
- Compounded Antibiotics have unpredictable quality control because they bypass FDA processes
- Compounded Antibiotics are advertised and sold in bulk to veterinarians
Generic Antibiotics
- Generic antibiotics are FDA approved
- They undergo testing and must have the same qualities of brand name antibiotics
Educating and Building Expertise
- There are gaps in knowledge and needed research
- Breakpoints for susceptibility and much extrapolation is needed
- Duration studies and optimal dosing studies are needed
- It is important for vets to stay up to date
Prescribing Antimicrobials
- The key questions include ensuring there is an infection, understanding the root cause, assessing the need for antibiotics, and selecting the best option.
Behavioral Influences
- There are many behavioral influences in prescribing antibiotics, such as client expectations, peer preassure, time of day, and fear of medical failure.
- It is important to build trust with clients to help with these concerns
Common Challenges for Antibiotic Approval
- A client might bring a cat in that is urinating outside the box
- The client might state that this happened before and wants a Convenia shot
- It is important to see what factors lead to this
- It is important to determine what diagnostic tests should be recommended and whether antibiotics are indicated
Common Scenarios
- Veterinarians may encounter clients who expect antibiotics for their pets, such as a 6-year-old dog presenting with actue colitis.
Responsible Use of Antibiotics
- In this scenario, many might expect metronidazole, or be always prescribed metronidazole
- When they are needed, antibiotics can be lifesaving but come with baggage, such as challenges administering, compliance issues, adverse effects, impacts on the GI microbiome, and cost.
Recognizing and Responding to Alarming Cultures
- A 12 year old hound dog is presented and is a recheck for diabetes
- routine work is ordered for her
- It is important to determine if antibiotics and treatment are needed
MDR Management
- The isolation of MDR Species should not affect decision making on whether to treat subclinical bacteria
- AMR are not more likely to cause disease than their susceptible counterparts
Handling CREs
- CRE is among the greatest threat to animal and human health and is impossible to treat
- This sign indicates that staff is in contact with a patient
- Steps should be taken to protect them
Responding to CREs
- Flier to help educate vets and staff -Important to have trained staff that minimize people involved
Client Discussions
- Clients need to know it is a public health concern and it can be very hard to treat in pets and people
- Precautions are need to avoid spread
- CRE is reportable in people in Kansas, but not animals.
- It is important to provide client resources
Home Care
- A copy of the treatment plan is sent to the primary vet.
- They need to recontact primary vets with treatment plan information
- There is a flier for the family to follow basic procedures
Organisms to be on Lookout
- Include CRE, carbapenem-resistant Pseudomonas, MRSA/MRSP, Corynebacterium ulcerans, Candida auris, and MDR Enterococcus.
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