Antimalarial Drugs: 8-Aminoquinolines and Primaquine SAR
10 Questions
0 Views

Antimalarial Drugs: 8-Aminoquinolines and Primaquine SAR

Created by
@OptimisticNewYork

Podcast Beta

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the mechanism of action of amodiaquine against Plasmodium parasites?

  • Causes fragmentation of the parasite's RNA and intercalates in its DNA (correct)
  • Interferes with the transport of sporozoites
  • Inhibits the transport of haemoglobin and other products of metabolism
  • Inhibits the conversion of haem to haemozoin

    • Which Plasmodium species is amodiaquine effective against at the erythrocytic stage?

  • P. vivax
  • P. malariae
  • P. ovale
  • P. falciparum (correct)

    • How does mefloquine act against Plasmodium parasites?

  • Binds to hemozoin, making a toxic complex for the parasite (correct)
  • Causes fragmentation of the parasite's RNA
  • Inhibits the conversion of haemoglobin to haemozoin
  • Interferes with the parasite's DNA replication

    • Which of the following is NOT a known effect of amodiaquine?

    <p>Active against intrahepatic forms</p> Signup and view all the answers

    What happens to haem in the parasite due to amodiaquine activity?

    <p>It builds up and kills the parasite by membranolytic action</p> Signup and view all the answers

    How does amodiaquine concentrate in the parasite's lysosome?

    <p>Through a host-specific drug-concentrating mechanism</p> Signup and view all the answers

    Which group reduces anti-malarial activity when introduced on the quinoline nucleus?

    <p>-Br group on the quinoline ring</p> Signup and view all the answers

    'Mefloquine (Lariam)' belongs to which group of compounds?

    <p>-Quinoline methanols</p> Signup and view all the answers

    'Amodiaquine is used in combination with an artemisinin derivative' primarily for what reason?

    <p>To treat uncomplicated malaria effectively</p> Signup and view all the answers

    What is the main reason for Amodiaquine's rapid schizontocidal effect?

    <p>Inhibition of hemozoin polymerase enzyme</p> Signup and view all the answers

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser