Antihypertensive Medications
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Questions and Answers

What is a potential adverse effect of Triamterene?

  • Tachycardia
  • Bradycardia
  • Hyperkalemia (correct)
  • Hypoglycemia

Which of the following medications is the drug of choice for treating pregnant women with mild preeclampsia?

  • ARBs
  • Beta blockers
  • ACEI
  • Labetalol and methyldopa (correct)

Why should beta blockers be used with caution in diabetic patients?

  • They can increase heart rate
  • They can cause hypoglycemia
  • They can increase blood pressure
  • They can suppress glycogenolysis and mask early signs of hypoglycemia (correct)

What is the preferred antihypertensive medication for African Americans?

<p>Diuretics (D)</p> Signup and view all the answers

Which of the following medication combinations are recommended when blood pressure cannot be adequately controlled by a single drug?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following medications are contraindicated in pregnancy?

<p>ACEIs, ARBs, and DRI's (B)</p> Signup and view all the answers

Which two medications are recommended for pregnant women with hypertension?

<p>Methyldopa and labetalol (D)</p> Signup and view all the answers

Why are ACEIs less effective in African Americans when used as monotherapy?

<p>Because they are less effective in african americans due to genetic differences (C)</p> Signup and view all the answers

What is a contraindication for using Nifedipine?

<p>Unstable Angina (B), Sick sinus syndrome (C)</p> Signup and view all the answers

Why is Nifedipine preferred over Verapamil in certain patients?

<p>Because it causes less calcium channel blockade in the heart (D)</p> Signup and view all the answers

What is a common adverse effect of Nifedipine?

<p>Flushing (D)</p> Signup and view all the answers

What is the therapeutic goal of Hydralazine?

<p>To reduce afterload in CHF (C)</p> Signup and view all the answers

What is prescribed to counteract reflex tachycardia caused by Hydralazine?

<p>Beta Blocker (D)</p> Signup and view all the answers

What is a potential interaction of Hydralazine with another medication?

<p>With beta blockers to counteract adverse effects (D)</p> Signup and view all the answers

What is a potential adverse effect of Hydralazine?

<p>Postural hypotension (B)</p> Signup and view all the answers

How long do symptoms of lupus-like syndrome caused by Hydralazine typically last?

<p>6 months (A)</p> Signup and view all the answers

What is the primary mechanism of action of digoxin?

<p>Increasing myocardial contractility and altering electrical activity of the heart (B)</p> Signup and view all the answers

What is a potential interaction of digoxin?

<p>Hypokalemia and increased risk of dysrhythmia (B)</p> Signup and view all the answers

Which of the following medications is preferred for people with lung issues?

<p>Metoprolol (C)</p> Signup and view all the answers

What is the first-line medication for someone with diabetes and/or kidney disease?

<p>Lisinopril (B)</p> Signup and view all the answers

What is the preferred medication for African Americans?

<p>Metoprolol (A)</p> Signup and view all the answers

Which of the following medications is contraindicated in pregnancy?

<p>Lisinopril (D)</p> Signup and view all the answers

What is the antidote for digoxin?

<p>Digibind (B)</p> Signup and view all the answers

What is the preferred medication for patients with type 2 diabetes who also have cardiovascular disease or cardiovascular risk, kidney disease, or heart failure?

<p>Sodium-glucose cotransporter 2 inhibitor and/or glucagon-like peptide 1 receptor agonist (D)</p> Signup and view all the answers

Flashcards

Preeclampsia

A condition marked by high blood pressure during pregnancy.

Ectopic pregnancy

The most common cause of death during the first trimester of pregnancy.

Hypertension in Pregnancy

Labetalol and methyldopa are the preferred drugs for treating mild preeclampsia in pregnant women.

Hypertension in Diabetics

ACEI, ARBs, and diuretics are preferred.

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Hypertension in Diabetics - Beta Blocker Caution

Beta blockers can be used with caution as they can suppress glycogenolysis and mask early signs of hypoglycemia.

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Hypertension in African Americans

Diuretics are the first choice of drugs for treating hypertension in African Americans.

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Less Effective Hypertension Treatments in African Americans

Monotherapy with beta blockers and ACEIs is less effective in African Americans compared to Caucasians.

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ACEI use in Specific African American Patients

ACEIs are recommended for African American patients with type 1 diabetes and proteinuria, or with hypertensive nephrosclerosis.

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Combination Therapy for Hypertension

Combinations like ACEI plus thiazide diuretic, ACEI plus CCB, or beta blocker plus thiazide are recommended when blood pressure cannot be controlled with single drugs.

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Contraindications in Pregnancy

ACEIs, ARBs, and DRI's are contraindicated in pregnancy.

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Pregnancy Safe Hypertension Treatments

Methyldopa and labetalol are recommended for pregnant women with hypertension.

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Digoxin Mechanism of Action

Digoxin (Lanoxin) increases myocardial contractility and alters electrical activity of the heart.

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Digoxin Uses

Digoxin is used to treat dysrhythmia (A-fib or flutter) or CHF.

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Digoxin Interaction with Hypokalemia

Hypokalemia can increase the risk of dysrhythmia when taking digoxin.

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Digoxin Monitoring

Digoxin levels, apical pulse, and signs of CHF should be monitored during treatment.

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Digoxin Patient Teaching

Patients should monitor their heart rate, hold digoxin if below 50 bpm, and be aware of signs of toxicity (altered heart rate or rhythm, visual or gastrointestinal disturbances).

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Digoxin Antidote

Digibind is the antidote for digoxin toxicity.

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Metoprolol Properties

Metoprolol (Lopressor) is a selective B-adrenergic blocker (B1) affecting only the heart, not the lungs.

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Metoprolol Preference in Lung Issues

Metoprolol is preferred for patients with lung issues as it does not affect the lungs.

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Medication Preference in Diabetic Hypertension

ACEI (Lisinopril) or ARB (losartan) are preferred for diabetic patients with high blood pressure.

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Medication Preference in African Americans

Metoprolol is preferred for African Americans with hypertension.

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First-Line Medication for Diabetes

Metformin is the first-line medication for treating patients with diabetes.

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Nifedipine Contraindications

Immediate-release nifedipine is associated with increased mortality in MI and unstable angina.

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Nifedipine Preference in Specific Heart Conditions

Nifedipine is preferred over verapamil for patients with AV block, heart failure, bradycardia, or sick sinus syndrome.

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Hydralazine Mechanism of Action

Hydralazine is a vasodilator that lowers blood pressure by dilating arterioles and reducing peripheral resistance.

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Therapeutic Goal of Hydralazine

Hydralazine is used to reduce blood pressure and afterload quickly in CHF.

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Hydralazine Adverse Effects

Hydralazine can cause postural hypotension, reflex tachycardia, myocardial contractility, sodium and water retention, and lupus-like syndrome.

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Study Notes

Adverse Effects of Triamterene (Dyrenium)

  • Hyperkalemia, nausea, vomiting, leg cramps, dizziness

Hypertension in Pregnancy

  • Labetalol and methyldopa are the drugs of choice for treating pregnant women with mild preeclampsia

Hypertension in Diabetics

  • ACEI, ARBs, and diuretics in low doses are the preferred antihypertensive drugs
  • Beta blockers should be used with caution as they can suppress glycogenolysis and mask early signs of hypoglycemia

Hypertension in African Americans

  • Diuretics are the first choice of drugs for treating hypertension in the African American population
  • Monotherapy with beta blockers and ACEIs is less effective in African Americans compared to Caucasians
  • ACEIs should be used in African American patients with type 1 diabetes and proteinuria, or with hypertensive nephrosclerosis

Combination Therapy for Hypertension

  • ACEI plus a thiazide diuretic, an ACEI plus a CCB, or a beta blocker plus a thiazide are recommended combinations when blood pressure cannot be adequately controlled by a single drug

Contraindications in Pregnancy

  • ACEIs, ARBs, and DRI's are counteracted in pregnancy
  • Methyldopa and labetalol are recommended for pregnant women

Digoxin (Lanoxin)

  • MOA: increases myocardial contractility, alters electrical activity of the heart
  • Use: treats dysrhythmia (A-fib or flutter) or CHF
  • Interactions: hypokalemia and increased risk of dysrhythmia
  • Monitoring: digoxin levels, apical pulse, and assess for decreased S/S of CHF
  • Teaching: how to monitor HR, hold if below 50, signs of toxicity (altered heart rate or rhythm, visual or gastrointestinal disturbances)
  • Antidote: Digibind

Metoprolol (Lopressor)

  • Selective B-Adrenergic Blocker (B1)
  • Preferred for people with lung issues because it only affects the heart, not the lungs
  • Treats: angina, HF, HTN, and MI

Medication Preferences

  • ACEI (Lisinopril) or ARB (losartan) are preferred for diabetic patients with high blood pressure
  • Metoprolol is preferred for African Americans
  • Metformin is the first medication to choose when treating patients with diabetes

Nifedipine (CCB)

  • Contraindications: IR dose is associated with increased mortality in MI and unstable angina
  • Preferred over verapamil for patients with AV block, heart failure, bradycardia, or sick sinus syndrome
  • Adverse effects: flushing, dizziness, peripheral edema, gingival hyperplasia, chronic eczematous rash
  • Patient education and monitoring: monitor BP and angina record, teach patients to keep an angina record and monitor their blood pressure and AE

Hydralazine

  • MOA: vasodilator, dilates arterioles and peripheral resistance, and arterial blood pressure falls
  • Therapeutic goal: to reduce BP and reduce afterload in a short time in CHF
  • Interactions and adverse effects: caution with use in other hypotensive drugs, postural hypotension, reflex tachy, myocardial contractility, NA and water retention, and lupus-like syndrome
  • If tachycardia reflex is severe, prescribe beta blocker to counteract it

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Description

This quiz covers the use of antihypertensive medications in specific populations, including individuals with triamterene side effects, pregnant women, and diabetics.

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