Antihistamines and Their Effects Quiz

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Questions and Answers

Which of the following is a side effect associated with first-generation antihistamines?

  • Jitteriness
  • Increased blood pressure
  • Dry mouth (correct)
  • Rebound nasal congestion

What effect can excessive intake of antihistamines lead to?

  • Decreased heart rate
  • Increased sleepiness
  • Normal blood pressure
  • Tachycardia (correct)

Which of the following is NOT a characteristic of second-generation antihistamines?

  • Examples include Cetirizine
  • Less CNS depression
  • Lower drowsiness incidence
  • Greater anticholinergic effects (correct)

What can happen if the use of certain antihistamine medications exceeds a specified duration?

<p>Rebound nasal congestion (B)</p> Signup and view all the answers

What should be considered when taking first-generation antihistamines alongside other depressants?

<p>They enhance drowsiness (D)</p> Signup and view all the answers

What condition can be a concern when antihistamines are administered in high doses?

<p>Cardiovascular issues (B)</p> Signup and view all the answers

What is true regarding the effects of antihistamines on the cardiovascular system?

<p>They cause heart irregularities (B)</p> Signup and view all the answers

Which of the following second-generation antihistamines is mentioned as an example?

<p>Cetirizine (B)</p> Signup and view all the answers

What effect could pseudoephedrine have when taken with beta blockers?

<p>Decrease the effect of beta blockers (B)</p> Signup and view all the answers

What is a potential side effect of intranasal glucocorticoids?

<p>Blurred vision (D)</p> Signup and view all the answers

Which of the following medications is classified as an intranasal glucocorticoid?

<p>Mometasone (D)</p> Signup and view all the answers

What is a common interaction of MAOIs when taken with certain medications?

<p>Hypertension or cardiac dysrhythmias (B)</p> Signup and view all the answers

What condition might result from taking glucocorticoids in excess?

<p>Cognitive confusion (C)</p> Signup and view all the answers

Which of the following side effects is associated with postural hypotension?

<p>Dizziness (D)</p> Signup and view all the answers

Intranasal glucocorticoids are effective because they....

<p>Have an inflammatory action (B)</p> Signup and view all the answers

What does the suffix '-sone' indicate about a medication?

<p>It is an intranasal glucocorticoid (B)</p> Signup and view all the answers

Which of the following is not a common side effect of mucolytics?

<p>Increased appetite (B)</p> Signup and view all the answers

Which of the following medications is NOT classified as a mucolytic?

<p>Ipratropium bromide (D)</p> Signup and view all the answers

What is the primary role of ipratropium bromide in the treatment of respiratory conditions?

<p>To dilate bronchioles (D)</p> Signup and view all the answers

Which of the following statements about chronic obstructive pulmonary disease (COPD) is true?

<p>It frequently results in irreversible lung tissue damage. (C)</p> Signup and view all the answers

What is a primary reason for combining ipratropium bromide with salbutamol during nebulization?

<p>To reduce palpitation (A)</p> Signup and view all the answers

Which of the following is NOT classified as a major pulmonary disorder associated with COPD?

<p>Pneumonia (A)</p> Signup and view all the answers

What is the mechanism of action of mucolytics?

<p>Liquefying and loosening mucous secretions (B)</p> Signup and view all the answers

In which of the following conditions is ipratropium bromide most commonly administered?

<p>Chronic obstructive pulmonary disease (COPD) (B)</p> Signup and view all the answers

What is the primary use of inhaled glucocorticoids in asthma management?

<p>To control symptoms of asthma more effectively than beta2 agonists (B)</p> Signup and view all the answers

Which of the following medications is not a glucocorticoid used in asthma treatment?

<p>Salbutamol (B)</p> Signup and view all the answers

What method should not be employed for administering glucocorticoids in asthma treatment?

<p>Subcutaneous injection (D)</p> Signup and view all the answers

What is a crucial reason for gargling after using inhalers?

<p>To minimize the risk of fungal infection in the oral mucosa (B)</p> Signup and view all the answers

Which of the following is an indication for using anti-inflammatory medications in asthma?

<p>If a patient has an asthmatic attack on maximum doses of bronchodilators (C)</p> Signup and view all the answers

Which of the following describes the issue with antiemetics used during vomiting?

<p>They can mask the underlying cause of vomiting for diagnosis. (D)</p> Signup and view all the answers

Which gastrointestinal issue is primarily treated with antidiarrheals?

<p>Diarrhea (B)</p> Signup and view all the answers

What potential issue can arise from using inhaled glucocorticoids improperly?

<p>Development of a fungal infection in the oral cavity (D)</p> Signup and view all the answers

What is the primary function of GH receptor antagonists like pegvisomant?

<p>To block GH receptor sites and normalize IGF-1 levels (A)</p> Signup and view all the answers

Which condition can be treated with dopamine agonists?

<p>Excess prolactin (PRL) (C)</p> Signup and view all the answers

What potential side effect is associated with somatostatin analogues?

<p>Diarrhea (D)</p> Signup and view all the answers

What is a common adverse reaction to posterior lobe agents like ADH preparations?

<p>Chest pain (C)</p> Signup and view all the answers

In what scenario is ADH contraindicated?

<p>Patients with hyponatremia (C)</p> Signup and view all the answers

How often are somatostatin analogues typically administered?

<p>Every 4 weeks (D)</p> Signup and view all the answers

Which hormone promotes water reabsorption from renal tubules?

<p>Antidiuretic hormone (ADH) (A)</p> Signup and view all the answers

What is the consequence of ADH deficiency in the body?

<p>Diabetes insipidus leading to large urine volumes (C)</p> Signup and view all the answers

What is the primary cause of chronic disease resulting from deficient glucose metabolism?

<p>Insufficient insulin secretion (C)</p> Signup and view all the answers

What is the effect of increasing urinary pH in patients?

<p>Enhances renal excretion of cystine (C)</p> Signup and view all the answers

Which condition is considered for the prophylaxis when rapidly ascending above 10,000 ft?

<p>Acute mountain sickness (B)</p> Signup and view all the answers

Loop diuretics act primarily at which part of the nephron?

<p>Loop of Henle (B)</p> Signup and view all the answers

What is the most significant side effect of excessive use of diuretics leading to metabolic alkalosis?

<p>Hypochloremic alkalosis (D)</p> Signup and view all the answers

Which medication is commonly used in conjunction with antiepileptic medications to enhance seizure control?

<p>Carbonic anhydrase inhibitors (C)</p> Signup and view all the answers

What is the effect of loop diuretics on fluid and electrolyte balance?

<p>They produce more loss of fluid and electrolytes than any other diuretics. (A)</p> Signup and view all the answers

For patients with edema, what should be monitored?

<p>Sites and extent of edema (D)</p> Signup and view all the answers

Flashcards

First-generation antihistamines

Antihistamines that can cause drowsiness, dry mouth, and other anticholinergic side effects. They can also cause central nervous system depression when taken with alcohol, narcotics, hypnotics, or barbiturates.

Second-generation antihistamines

Antihistamines that have fewer anticholinergic effects and cause less drowsiness than first-generation antihistamines.

Adverse effect of antihistamine

Tachycardia (fast heart rate) can occur with antihistamines, especially during a non-inflammatory process. This is because the body compensates for blood vessel dilation.

Rebound nasal congestion

A side effect that can happen if longer courses of an antihistamine are used, exceeding the prescribed duration.

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Drug Interactions (Pseudoephedrine)

Pseudoephedrine may reduce the effectiveness of beta-blockers, and cause hypertension or cardiac issues when taken with MAOI's (monoamine oxidase inhibitors).

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Drug Interactions (Coffee/Tea)

Coffee and tea can increase restlessness and palpitations.

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Intranasal Glucocorticoids

Effective for allergic rhinitis; they reduce inflammation, lessening symptoms like runny nose, sneezing, and congestion.

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Intranasal Glucocorticoid Examples

Beclomethasone, Budesonide, Dexamethasone, Flunisolide, Fluticasone, Mometasone, Triamcinolone

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Intranasal Glucocorticoid Deactivation

Intranasal glucocorticoids quickly become inactive after being absorbed.

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Dry Mouth (Side Effect)

A common side effect of some medications.

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Blurred Vision (Side Effect)

Another potential side effect of certain medications.

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Postural Hypotension

Dizziness due to a drop in blood pressure when standing up.

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Mucolytics

Substances that act as detergents to liquefy and loosen thick mucus secretions, enabling easier expectoration.

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Side Effects of Mucolytics

Possible adverse reactions to mucolytic medications, including dry mouth, constipation, vomiting, dyspepsia, abdominal pain, depression, insomnia, headache, and joint pain.

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COPD

Chronic Obstructive Pulmonary Disease – a major lower respiratory tract disorder characterized by airway obstruction and increased airway resistance.

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Ipratropium Bromide

A medication used to dilate bronchioles, treating asthmatic conditions. It has fewer systemic effects compared to other medications.

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Lower Respiratory Tract Disorders

Conditions affecting the lower parts of the respiratory system, including COPD and restrictive pulmonary disease.

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Bronchodilation

Widening of the bronchial passages, allowing easier air flow

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Chronic Bronchitis

A lower respiratory disorder characterized by chronic inflammation of the bronchi, often leading to irreversible lung damage.

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Bronchiectasis

A persistent widening of the bronchi, frequently resulting from recurring infections and inflammation, leading to irreversible lung damage.

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Emphysema

A type of COPD characterized by the destruction of air sacs in the lungs, often due to smoking or inhaling harmful substances.

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Asthma

A respiratory disorder characterized by episodes of wheezing, breathlessness, chest tightness, and coughing.

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Inhaled glucocorticoids

More effective for controlling asthma symptoms than beta2 agonists, particularly in reducing bronchial hyperresponsiveness.

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Asthma treatment

Inhaled glucocorticoids are preferred over oral preparations unless oral preparations fail to control the asthma symptoms.

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Gastrontestinal Tract Disorders

Disorders including vomiting, diarrhea, and constipation.

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Anti-inflammatory action

The ability of a drug to reduce inflammation, relieving asthma symptoms.

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Antiemetics

Drugs used to control vomiting.

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MDI Inhaler

A device used to deliver medication directly into the lungs for treatment of asthma conditions.

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Asthma unresponsive to bronchodilators

When asthma symptoms are not relieved by bronchodilating medications.

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Maximum doses of theophylline or adrenergic drugs

The highest recommended dosage for these medications to be given in asthma cases when it is unresponsive to bronchodilators.

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Fungal infection

An infection caused by fungi.

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Vomiting (emesis)

The forceful expulsion of gastric contents, with various causes.

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GH receptor antagonist

Blocks growth hormone receptors, normalizing IGF-1 levels.

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Pegvisomant

A GH receptor antagonist administered by injection, for abnormal growth.

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Elevated hepatic transaminases

High levels of liver enzymes in blood tests.

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Somatostatin analogues

Drugs that mimic somatostatin, controlling GH and other hormones.

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Lanreotide

A somatostatin analogue with a 28-day duration.

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Posterior lobe (neurohypophysis) agents

Agents affecting the posterior pituitary, influencing water balance.

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ADH (antidiuretic hormone)

A hormone that promotes water reabsorption by kidneys.

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Diabetes insipidus

Condition where body loses too much water due to ADH deficiency.

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ADH preparations (vasopressin, desmopressin)

Treatments for ADH deficiency, often given intranasally or by injection.

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Contraindications for ADH

Usage restricted to patients with moderate/severe kidney disease or hyponatremia.

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Prolactin (PRL)

Hormone that stimulates lactation.

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Dopamine agonists

Drugs to treat excess prolactin.

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Bromocriptine/Cabergoline

Two dopamine agonists used for excess prolactin.

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Chronic Disease - Glucose Deficiency

A long-term illness caused by insufficient glucose metabolism, often due to inadequate insulin secretion.

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Loop Diuretics

Diuretics (drugs that increase urine production) that act in the loop of Henle, causing significant fluid and electrolyte loss.

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Baseline Data

Initial measurements of various factors (weight, blood pressure, electrolytes) used as a reference point for monitoring patient progress and treatment effectiveness.

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Urinary Alkalinization

Increasing the pH of urine, which can help the body eliminate certain substances more efficiently.

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Carbonic Anhydrase Inhibitors

Drugs that block an enzyme involved in fluid balance, often used to reduce eye pressure.

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Acute Mountain Sickness

Illness caused by rapidly ascending to high altitudes, often leading to cerebral and pulmonary edema.

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Metabolic Alkalosis

A condition characterized by abnormally high blood pH, sometimes due to diuretic misuse.

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Epilepsy Treatment

Medication use to reduce the severity and frequency of seizures in patients with epilepsy, often combined with other antiepileptic drugs.

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Hydrocephalus

A condition characterized by an abnormal buildup of cerebrospinal fluid (CSF) in the brain.

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ACE Inhibitors

Drugs that inhibit an enzyme involved in blood pressure regulation, often used in treating high blood pressure.

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