Anticoagulant Fondaparinux (Arixtra®)
25 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the major difference between Dalteparin and Fondaparinux in terms of administration?

  • Dalteparin needs renal dose adjustment while Fondaparinux does not (correct)
  • Dalteparin crosses the placenta while Fondaparinux does not
  • Dalteparin is given SC every 12 hours while Fondaparinux is given SC once daily
  • Dalteparin is given SC once daily while Fondaparinux is given IV every 12 hours

    • Which medication is used for the treatment and prophylaxis of deep vein thrombosis as well as in patients with heparin-induced thrombocytopenia (off label)?

  • Enoxaparin
  • Fondaparinux (correct)
  • Rivaroxaban
  • Bivalirudin

    • Which novel oral anticoagulant (NOAC) is a direct thrombin inhibitor?

  • Rivaroxaban
  • Edoxaban
  • Dabigatran (correct)
  • Apixaban

    • What is the mechanism of action of heparin (UFH)?

    <p>Binds to plasma proteins to accelerate Anti-thrombin (ATIII) action</p> Signup and view all the answers

    What is the primary method of action of Argatroban?

    <p>Is a direct thrombin inhibitor</p> Signup and view all the answers

    Why is intramuscular (IM) administration of heparin (UFH) not recommended?

    <p>Risk of causing hematoma formation</p> Signup and view all the answers

    Which medication has dosing adjustments based on age, weight, and renal function for stroke prevention in nonvalvular atrial fibrillation?

    <p>Apixaban</p> Signup and view all the answers

    Which of the following coagulation factors is NOT inhibited by heparin (UFH)?

    <p>Factor V</p> Signup and view all the answers

    Why is IV infusion of heparin (UFH) preferred over subcutaneous injection for certain situations?

    <p>IV infusion allows for a quick onset and quick off effect</p> Signup and view all the answers

    What is an example of SC dosing frequency for heparin (UFH) used for prophylaxis of DVT and PE?

    <p>5000 units SC every 8-12 hours</p> Signup and view all the answers

    What is the end result of the Coagulation Cascade?

    <p>Conversion of fibrinogen to fibrin by thrombin</p> Signup and view all the answers

    Which of the following statements about indirect thrombin inhibitors is true?

    <p>Includes unfractionated heparin (UFH) as a prototype</p> Signup and view all the answers

    What is the general source of unfractionated heparin (UFH)?

    <p>Porcine/bovine intestinal mucosa</p> Signup and view all the answers

    Why is unfractionated heparin (UFH) considered too large to be absorbed?

    <p>Its large molecular size</p> Signup and view all the answers

    What is the main role of heparin (UFH) in pregnancy?

    <p>Can be used safely due to its large molecule size</p> Signup and view all the answers

    What is the specific activity of Fondaparinux (Arixtra®) in terms of increasing the neutralizing action of ATIII on activated Factor X?

    <p>300-fold</p> Signup and view all the answers

    Which direct thrombin inhibitor was discontinued in 2012 due to anaphylactic reactions?

    <p>Lepirudin</p> Signup and view all the answers

    Which direct thrombin inhibitor has the longest half-life of 25 minutes?

    <p>Bivalirudin</p> Signup and view all the answers

    Which novel oral anticoagulant (NOAC) has a reversal agent called Praxbind (idarucizumab)?

    <p>Dabigatran</p> Signup and view all the answers

    Which direct factor Xa inhibitor is indicated for preventing stroke in nonvalvular atrial fibrillation?

    <p>Apixaban</p> Signup and view all the answers

    Which NOAC does not require routine anticoagulation tests?

    <p>Apixaban</p> Signup and view all the answers

    Which direct factor Xa inhibitor requires dose reduction with strong inhibitors of both CYP p450 3A4 and P-gp?

    <p>Rivaroxaban</p> Signup and view all the answers

    Which NOAC is recommended at a dose of 2.5 mg twice daily for DVT/PE prevention post hip or knee replacement?

    <p>Apixaban</p> Signup and view all the answers

    Which NOAC is contraindicated with prosthetic heart valves and severe liver impairment?

    <p>Apixaban</p> Signup and view all the answers

    Which NOAC has a dosing regimen that includes 10 mg twice daily for the first week followed by 5 mg twice daily for DVT/PE treatment?

    <p>Apixaban</p> Signup and view all the answers

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser