25 Questions
What is the major difference between Dalteparin and Fondaparinux in terms of administration?
Dalteparin needs renal dose adjustment while Fondaparinux does not
Which medication is used for the treatment and prophylaxis of deep vein thrombosis as well as in patients with heparin-induced thrombocytopenia (off label)?
Fondaparinux
Which novel oral anticoagulant (NOAC) is a direct thrombin inhibitor?
Dabigatran
What is the mechanism of action of heparin (UFH)?
Binds to plasma proteins to accelerate Anti-thrombin (ATIII) action
What is the primary method of action of Argatroban?
Is a direct thrombin inhibitor
Why is intramuscular (IM) administration of heparin (UFH) not recommended?
Risk of causing hematoma formation
Which medication has dosing adjustments based on age, weight, and renal function for stroke prevention in nonvalvular atrial fibrillation?
Apixaban
Which of the following coagulation factors is NOT inhibited by heparin (UFH)?
Factor V
Why is IV infusion of heparin (UFH) preferred over subcutaneous injection for certain situations?
IV infusion allows for a quick onset and quick off effect
What is an example of SC dosing frequency for heparin (UFH) used for prophylaxis of DVT and PE?
5000 units SC every 8-12 hours
What is the end result of the Coagulation Cascade?
Conversion of fibrinogen to fibrin by thrombin
Which of the following statements about indirect thrombin inhibitors is true?
Includes unfractionated heparin (UFH) as a prototype
What is the general source of unfractionated heparin (UFH)?
Porcine/bovine intestinal mucosa
Why is unfractionated heparin (UFH) considered too large to be absorbed?
Its large molecular size
What is the main role of heparin (UFH) in pregnancy?
Can be used safely due to its large molecule size
What is the specific activity of Fondaparinux (Arixtra®) in terms of increasing the neutralizing action of ATIII on activated Factor X?
300-fold
Which direct thrombin inhibitor was discontinued in 2012 due to anaphylactic reactions?
Lepirudin
Which direct thrombin inhibitor has the longest half-life of 25 minutes?
Bivalirudin
Which novel oral anticoagulant (NOAC) has a reversal agent called Praxbind (idarucizumab)?
Dabigatran
Which direct factor Xa inhibitor is indicated for preventing stroke in nonvalvular atrial fibrillation?
Apixaban
Which NOAC does not require routine anticoagulation tests?
Apixaban
Which direct factor Xa inhibitor requires dose reduction with strong inhibitors of both CYP p450 3A4 and P-gp?
Rivaroxaban
Which NOAC is recommended at a dose of 2.5 mg twice daily for DVT/PE prevention post hip or knee replacement?
Apixaban
Which NOAC is contraindicated with prosthetic heart valves and severe liver impairment?
Apixaban
Which NOAC has a dosing regimen that includes 10 mg twice daily for the first week followed by 5 mg twice daily for DVT/PE treatment?
Apixaban
Learn about the synthetic anticoagulant Fondaparinux, its mechanism of action, clinical uses, and dosage regimens. Understand its role in preventing and treating conditions such as DVT, PE, and HIT. Explore the need for renal dose adjustment and its pharmacological properties.
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