Antibody Structure and Isolation Quiz
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Questions and Answers

How many different MHC-II molecules can a single cell express on its surface?

  • Two
  • Eight
  • Four
  • Six (correct)
  • Which domain of the MHC-I molecule is responsible for binding to the CD8 cell?

  • a1 domain
  • a3 domain (correct)
  • a2 domain
  • b2-microglobulin
  • Which part of the MHC-I molecule contains the peptide-binding groove?

  • The entire MHC-I molecule
  • Between the a2 and a3 domains
  • The b2-microglobulin
  • Between the a1 and a2 domains (correct)
  • Which part of the MHC-II molecule has variability between different alleles?

    <p>a1 and b1 domains</p> Signup and view all the answers

    What is the name of the invariant polypeptide that associates non-covalently with the MHC-I molecule?

    <p>b2-microglobulin</p> Signup and view all the answers

    Which gene system in the human body is the most highly polymorphic?

    <p>HLA</p> Signup and view all the answers

    What is the molecular weight of IgM?

    <p>900KD</p> Signup and view all the answers

    Which immunoglobulin is a PENTAMER with a J-chain?

    <p>IgM</p> Signup and view all the answers

    What is the primary biological function of IgM?

    <p>Activating the complement system</p> Signup and view all the answers

    Which phase of the antibody response sees the highest concentration of secreted antibodies?

    <p>Exponential phase</p> Signup and view all the answers

    Which immunoglobulin is known for its occurrence against ABO blood system antigens?

    <p>IgM</p> Signup and view all the answers

    What is the half-life of IgM?

    <p>5 days</p> Signup and view all the answers

    What is the primary function of factor H in the complement system?

    <p>To regulate the alternative pathway by binding to C3b and preventing factor B binding</p> Signup and view all the answers

    Which of the following is not a cofactor for factor-I in the complement system?

    <p>Decay accelerating factor (DAF, CD55)</p> Signup and view all the answers

    Which of the following is not an anaphylatoxin produced by the complement system?

    <p>C6a</p> Signup and view all the answers

    What is the primary function of CD59 in the complement system?

    <p>To prevent the polymerization of C9 in the membrane attack complex</p> Signup and view all the answers

    Which of the following is a major opsonin produced by the complement system?

    <p>iC3b</p> Signup and view all the answers

    What is the primary function of the fluid phase proteins SP-40 (clusterin) and S-protein (vitronectin) in the complement system?

    <p>To prevent the binding of C5b-6 and C5b-6-9 to cell surfaces</p> Signup and view all the answers

    What is the technique used for isolating immunoglobulins from blood serum?

    <p>Electrophoresis</p> Signup and view all the answers

    What is the molecular weight of each of the two chains that make up an immunoglobulin?

    <p>22,000 Da</p> Signup and view all the answers

    Which type of proteins helped in studying immunoglobulins and are considered homogeneous?

    <p>Myeloma proteins</p> Signup and view all the answers

    Which type of chains in an immunoglobulin are known as the Light chains?

    <p>Chains with 22,000 Da each</p> Signup and view all the answers

    What is the name given to the two fragments produced by treating immunoglobulin with papain that have the ability to bind antigens?

    <p>Fab regions</p> Signup and view all the answers

    What result is obtained when treating immunoglobulin with mercaptoethanol (S-S)?

    <p>Production of three fragments</p> Signup and view all the answers

    Which type of immunity is considered the most effective mechanism during the course of infection?

    <p>Cell-mediated immunity</p> Signup and view all the answers

    What is the primary cause of tissue damage in fungal infections?

    <p>Proteolytic enzymes</p> Signup and view all the answers

    Which organism is mentioned as the most common pathogenic fungus in the text?

    <p>Candida albicans</p> Signup and view all the answers

    How do spirochetes differ from other bacteria in terms of their cell wall?

    <p>They lack a cell wall</p> Signup and view all the answers

    Which type of immune cells play the most important role in fungal infections according to the text?

    <p>T cells</p> Signup and view all the answers

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