Antibody Structure and Isolation Quiz

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How many different MHC-II molecules can a single cell express on its surface?

Two

Eight

Four

Six (correct)

Which domain of the MHC-I molecule is responsible for binding to the CD8 cell?

a1 domain

a3 domain (correct)

a2 domain

b2-microglobulin

Which part of the MHC-I molecule contains the peptide-binding groove?

The entire MHC-I molecule

Between the a2 and a3 domains

The b2-microglobulin

Between the a1 and a2 domains (correct)

Which part of the MHC-II molecule has variability between different alleles?

a1 and b1 domains Signup and view all the answers

What is the name of the invariant polypeptide that associates non-covalently with the MHC-I molecule?

b2-microglobulin Signup and view all the answers

Which gene system in the human body is the most highly polymorphic?

HLA Signup and view all the answers

What is the molecular weight of IgM?

900KD Signup and view all the answers

Which immunoglobulin is a PENTAMER with a J-chain?

IgM Signup and view all the answers

What is the primary biological function of IgM?

Activating the complement system Signup and view all the answers

Which phase of the antibody response sees the highest concentration of secreted antibodies?

Exponential phase Signup and view all the answers

Which immunoglobulin is known for its occurrence against ABO blood system antigens?

IgM Signup and view all the answers

What is the half-life of IgM?

5 days Signup and view all the answers

What is the primary function of factor H in the complement system?

To regulate the alternative pathway by binding to C3b and preventing factor B binding Signup and view all the answers

Which of the following is not a cofactor for factor-I in the complement system?

Decay accelerating factor (DAF, CD55) Signup and view all the answers

Which of the following is not an anaphylatoxin produced by the complement system?

C6a Signup and view all the answers

What is the primary function of CD59 in the complement system?

To prevent the polymerization of C9 in the membrane attack complex Signup and view all the answers

Which of the following is a major opsonin produced by the complement system?

iC3b Signup and view all the answers

What is the primary function of the fluid phase proteins SP-40 (clusterin) and S-protein (vitronectin) in the complement system?

To prevent the binding of C5b-6 and C5b-6-9 to cell surfaces Signup and view all the answers

What is the technique used for isolating immunoglobulins from blood serum?

Electrophoresis Signup and view all the answers

What is the molecular weight of each of the two chains that make up an immunoglobulin?

22,000 Da Signup and view all the answers

Which type of proteins helped in studying immunoglobulins and are considered homogeneous?

Myeloma proteins Signup and view all the answers

Which type of chains in an immunoglobulin are known as the Light chains?

Chains with 22,000 Da each Signup and view all the answers

What is the name given to the two fragments produced by treating immunoglobulin with papain that have the ability to bind antigens?

Fab regions Signup and view all the answers

What result is obtained when treating immunoglobulin with mercaptoethanol (S-S)?

Production of three fragments Signup and view all the answers

Which type of immunity is considered the most effective mechanism during the course of infection?

Cell-mediated immunity Signup and view all the answers

What is the primary cause of tissue damage in fungal infections?

Proteolytic enzymes Signup and view all the answers

Which organism is mentioned as the most common pathogenic fungus in the text?

Candida albicans Signup and view all the answers

How do spirochetes differ from other bacteria in terms of their cell wall?

They lack a cell wall Signup and view all the answers

Which type of immune cells play the most important role in fungal infections according to the text?

T cells Signup and view all the answers