Antibody Structure and Isolation Quiz
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Questions and Answers

How many different MHC-II molecules can a single cell express on its surface?

  • Two
  • Eight
  • Four
  • Six (correct)

Which domain of the MHC-I molecule is responsible for binding to the CD8 cell?

  • a1 domain
  • a3 domain (correct)
  • a2 domain
  • b2-microglobulin

Which part of the MHC-I molecule contains the peptide-binding groove?

  • The entire MHC-I molecule
  • Between the a2 and a3 domains
  • The b2-microglobulin
  • Between the a1 and a2 domains (correct)

Which part of the MHC-II molecule has variability between different alleles?

<p>a1 and b1 domains (A)</p> Signup and view all the answers

What is the name of the invariant polypeptide that associates non-covalently with the MHC-I molecule?

<p>b2-microglobulin (B)</p> Signup and view all the answers

Which gene system in the human body is the most highly polymorphic?

<p>HLA (A)</p> Signup and view all the answers

What is the molecular weight of IgM?

<p>900KD (C)</p> Signup and view all the answers

Which immunoglobulin is a PENTAMER with a J-chain?

<p>IgM (B)</p> Signup and view all the answers

What is the primary biological function of IgM?

<p>Activating the complement system (A)</p> Signup and view all the answers

Which phase of the antibody response sees the highest concentration of secreted antibodies?

<p>Exponential phase (D)</p> Signup and view all the answers

Which immunoglobulin is known for its occurrence against ABO blood system antigens?

<p>IgM (D)</p> Signup and view all the answers

What is the half-life of IgM?

<p>5 days (C)</p> Signup and view all the answers

What is the primary function of factor H in the complement system?

<p>To regulate the alternative pathway by binding to C3b and preventing factor B binding (A)</p> Signup and view all the answers

Which of the following is not a cofactor for factor-I in the complement system?

<p>Decay accelerating factor (DAF, CD55) (B)</p> Signup and view all the answers

Which of the following is not an anaphylatoxin produced by the complement system?

<p>C6a (A)</p> Signup and view all the answers

What is the primary function of CD59 in the complement system?

<p>To prevent the polymerization of C9 in the membrane attack complex (A)</p> Signup and view all the answers

Which of the following is a major opsonin produced by the complement system?

<p>iC3b (A)</p> Signup and view all the answers

What is the primary function of the fluid phase proteins SP-40 (clusterin) and S-protein (vitronectin) in the complement system?

<p>To prevent the binding of C5b-6 and C5b-6-9 to cell surfaces (A)</p> Signup and view all the answers

What is the technique used for isolating immunoglobulins from blood serum?

<p>Electrophoresis (A)</p> Signup and view all the answers

What is the molecular weight of each of the two chains that make up an immunoglobulin?

<p>22,000 Da (A)</p> Signup and view all the answers

Which type of proteins helped in studying immunoglobulins and are considered homogeneous?

<p>Myeloma proteins (C)</p> Signup and view all the answers

Which type of chains in an immunoglobulin are known as the Light chains?

<p>Chains with 22,000 Da each (C)</p> Signup and view all the answers

What is the name given to the two fragments produced by treating immunoglobulin with papain that have the ability to bind antigens?

<p>Fab regions (B)</p> Signup and view all the answers

What result is obtained when treating immunoglobulin with mercaptoethanol (S-S)?

<p>Production of three fragments (C)</p> Signup and view all the answers

Which type of immunity is considered the most effective mechanism during the course of infection?

<p>Cell-mediated immunity (C)</p> Signup and view all the answers

What is the primary cause of tissue damage in fungal infections?

<p>Proteolytic enzymes (B)</p> Signup and view all the answers

Which organism is mentioned as the most common pathogenic fungus in the text?

<p>Candida albicans (B)</p> Signup and view all the answers

How do spirochetes differ from other bacteria in terms of their cell wall?

<p>They lack a cell wall (D)</p> Signup and view all the answers

Which type of immune cells play the most important role in fungal infections according to the text?

<p>T cells (A)</p> Signup and view all the answers

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