12 Questions
What process further enhances diversity in DNA sequences in mature activated B cells?
Somatic hypermutation
What was discovered 25 years ago using restriction enzyme analysis and Southern blotting?
DNA rearrangement within immunoglobulin genes
What distinguishes somatic recombination from meiotic recombination?
Recombines gene segments in B-lymphocytes
Which region of the immunoglobulin gene is rearranged in mature B lymphocytes?
V region
What is the consequence of gene rearrangement in antibody-producing B cells?
Closer proximity of V- and C-region sequences
Which technique identified V- and C-region sequences on the same DNA fragment in antibody-producing B cells?
Southern blotting
What is the total number of antibody specificities available to an individual known as?
Immunoglobulin repertoire
How is the diversity of the antibody repertoire generated?
Through DNA rearrangements during B-cell development
What limits the number of antibody specificities present at any one time in an individual?
Total number of B cells
What is the main difference between the germline theory and somatic diversification theories regarding antibody repertoire diversity?
Somatic diversification theories propose DNA rearrangements, while germline theory suggests inherited genes
What is the term used to describe the unique affinity or binding strength of each antibody molecule for an antigen?
Specificity
What do somatic diversification theories propose regarding the generation of the antibody repertoire?
It is generated from a limited number of inherited sequences that undergo alteration within B cells
Explore the concept of antibody repertoire and immunoglobulin diversity in the immune system. Learn about the diversity of antibody molecules and their unique affinities and specificities for antigens.
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