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Antibody Repertoire and Immunoglobulin Diversity

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Antibody Repertoire and Immunoglobulin Diversity

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Questions and Answers

What process further enhances diversity in DNA sequences in mature activated B cells?

Gene rearrangement

Somatic hypermutation (correct)

Selection of inherited gene segments

Meiotic recombination

What was discovered 25 years ago using restriction enzyme analysis and Southern blotting?

DNA rearrangement within immunoglobulin genes (correct)

Germline genes

Meiotic recombination

Multiple V regions

What distinguishes somatic recombination from meiotic recombination?

Takes place during gamete production

Involves V and C regions

Recombines gene segments in B-lymphocytes (correct)

Occurs in B cells

Which region of the immunoglobulin gene is rearranged in mature B lymphocytes?

V region Signup and view all the answers

What is the consequence of gene rearrangement in antibody-producing B cells?

Closer proximity of V- and C-region sequences Signup and view all the answers

Which technique identified V- and C-region sequences on the same DNA fragment in antibody-producing B cells?

Southern blotting Signup and view all the answers

What is the total number of antibody specificities available to an individual known as?

Immunoglobulin repertoire Signup and view all the answers

How is the diversity of the antibody repertoire generated?

Through DNA rearrangements during B-cell development Signup and view all the answers

What limits the number of antibody specificities present at any one time in an individual?

Total number of B cells Signup and view all the answers

What is the main difference between the germline theory and somatic diversification theories regarding antibody repertoire diversity?

Somatic diversification theories propose DNA rearrangements, while germline theory suggests inherited genes Signup and view all the answers

What is the term used to describe the unique affinity or binding strength of each antibody molecule for an antigen?

Specificity Signup and view all the answers

What do somatic diversification theories propose regarding the generation of the antibody repertoire?

It is generated from a limited number of inherited sequences that undergo alteration within B cells Signup and view all the answers