Podcast
Questions and Answers
What process further enhances diversity in DNA sequences in mature activated B cells?
What process further enhances diversity in DNA sequences in mature activated B cells?
- Gene rearrangement
- Somatic hypermutation (correct)
- Selection of inherited gene segments
- Meiotic recombination
What was discovered 25 years ago using restriction enzyme analysis and Southern blotting?
What was discovered 25 years ago using restriction enzyme analysis and Southern blotting?
- DNA rearrangement within immunoglobulin genes (correct)
- Germline genes
- Meiotic recombination
- Multiple V regions
What distinguishes somatic recombination from meiotic recombination?
What distinguishes somatic recombination from meiotic recombination?
- Takes place during gamete production
- Involves V and C regions
- Recombines gene segments in B-lymphocytes (correct)
- Occurs in B cells
Which region of the immunoglobulin gene is rearranged in mature B lymphocytes?
Which region of the immunoglobulin gene is rearranged in mature B lymphocytes?
What is the consequence of gene rearrangement in antibody-producing B cells?
What is the consequence of gene rearrangement in antibody-producing B cells?
Which technique identified V- and C-region sequences on the same DNA fragment in antibody-producing B cells?
Which technique identified V- and C-region sequences on the same DNA fragment in antibody-producing B cells?
What is the total number of antibody specificities available to an individual known as?
What is the total number of antibody specificities available to an individual known as?
How is the diversity of the antibody repertoire generated?
How is the diversity of the antibody repertoire generated?
What limits the number of antibody specificities present at any one time in an individual?
What limits the number of antibody specificities present at any one time in an individual?
What is the main difference between the germline theory and somatic diversification theories regarding antibody repertoire diversity?
What is the main difference between the germline theory and somatic diversification theories regarding antibody repertoire diversity?
What is the term used to describe the unique affinity or binding strength of each antibody molecule for an antigen?
What is the term used to describe the unique affinity or binding strength of each antibody molecule for an antigen?
What do somatic diversification theories propose regarding the generation of the antibody repertoire?
What do somatic diversification theories propose regarding the generation of the antibody repertoire?
