Antibiotics and Resistance Quiz
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Questions and Answers

Quinolones :

  • Cause ototoxicity and nephrotoxicity (correct)
  • Inhibit cell wall synthesis
  • Good for atypical organism such as mycoplasma, chlamydia, legionella (correct)
  • Include tobramycin
  • Have broad spectrum against gram-positive bacteria (correct)
  • Each of the following concerning clindamycin is correct EXCEPT :

  • Causes diarrhea
  • Inhibits protein synthesis
  • Inhibits microbial DNA synthesis by blocking DNA gyrase (correct)
  • Has special role in treating streptococcus necrotizing fasciitis
  • Effective in anaerobes
  • The following antibacterial drugs inhibit bacterial protein synthesis EXCEPT :

  • Lincomycin
  • Erythromycin
  • Aminoglycoside
  • Vancomycin
  • Tetracyclines (correct)
  • The following are factors to be considered when chosen antibacterial drugs EXCEPT :

    <p>Patients height (B)</p> Signup and view all the answers

    Bacterial antibiotic resistance may be :

    <p>Rarely by plasmid conjugation (A), By transduction which is uptake of the extracellular DNA by bacteria, thus altering its genotype (B), Due to active efflux. (C), Due to increased production of inhibited compound (D), Due to cell permeability changes (E)</p> Signup and view all the answers

    Systemic Inflammatory response syndrome

    <p>Number of red blood cells are increased (A), Body temperature increased or decreased (C), Respiratory rate is decreased (D)</p> Signup and view all the answers

    In sepsis :

    <p>Rigors are not characteristic (A), Vascular tone is reduced (B), Circulation support and anti infection drugs are not essential (C), Blood culture and sensitivity, not required (D)</p> Signup and view all the answers

    Flashcards

    What is Pyrexia of Unknown Origin (PUO)?

    A febrile illness with an unknown cause, often presenting with atypical symptoms. Common causes include hidden abscesses and typical diseases presenting in unusual ways.

    What is Clindamycin?

    A class of antibiotics that primarily target Gram-positive bacteria and have a special role in treating Streptococcus necrotizing fasciitis (necrotizing fasciitis).

    What are Macrolides?

    A class of antibiotics effective against a wide range of bacteria, including Mycoplasma, Chlamydia, and Legionella. They inhibit protein synthesis.

    How do Bactericidal Drugs work?

    Antibiotics that disrupt the synthesis of bacterial cell walls, leading to cell death. Examples include penicillin and cephalosporins.

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    How do Bacteriostatic Drugs work?

    Antibiotics that suppress bacterial growth but do not directly kill them. Examples include erythromycin and tetracycline.

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    What is Tetanus?

    A debilitating condition characterized by muscle spasms, rigidity, and lockjaw. Caused by the bacterium Clostridium tetani.

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    What is Ascaris lumbricoides infection?

    A common, soil-transmitted parasitic infection affecting the intestines. Infection occurs through the ingestion of Ascaris eggs, leading to larval migration and adult worm development in the gut.

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    What is Trichuris trichiura infection?

    A parasitic infection caused by the whipworm Trichuris trichiura. The parasite embeds its anterior part into the intestinal mucosa, feeding off the host's blood.

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    What is Hookworm infection?

    An infection caused by hookworms, soil-transmitted nematodes that reside in the small intestine. The larvae burrow into the skin and travel through the bloodstream.

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    What is Hymenolepis nana infection?

    An infection caused by the dwarf tapeworm Hymenolepis nana. Transmission occurs through ingestion of eggs, and the parasite can undergo internal autoinfection.

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    What is Amoebiasis?

    A protozoan disease caused by the parasite Entamoeba histolytica. Infection occurs through the ingestion of contaminated food or water containing cysts.

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    What is Brucellosis?

    An infectious disease caused by bacteria of the genus Brucella. It is a zoonotic disease, commonly affecting animals like cattle and goats, and transmitted to humans.

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    What is Typhoid Fever?

    A serious bacterial infection caused by Salmonella Typhi. It is spread through contaminated food and water, and can lead to complications like intestinal perforation and myocarditis.

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    What is Malaria?

    A potentially fatal infectious disease caused by Plasmodium parasites. It is transmitted through the bite of infected mosquitos.

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    What is Post-kala-azar dermal leishmaniasis (PKDL)?

    A complication of visceral leishmaniasis, characterized by skin lesions. These lesions are usually non-ulcerative, appearing as papules, nodules, or hypo-pigmented areas of skin discoloration.

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    What is Tetanus?

    A bacterial infection caused by Clostridium tetani. The bacteria produce a powerful neurotoxin that leads to muscle spasms, rigidity, and lockjaw.

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    What is the first-line treatment for tetanic seizures in newborns?

    The standard treatment for tetanic seizures in newborns, involving intravenous administration of the anticonvulsant drug lidocaine.

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    What is Leishmaniasis?

    A disease caused by the Leishmania parasite, affecting the skin, mucous membranes, or internal organs.

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    What is Human African Trypanosomiasis (HAT)?

    A devastating parasitic disease caused by the Trypanosoma brucei parasite, affecting the central nervous system. It is spread through the bite of the tsetse fly.

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    What is Schistosomiasis?

    A parasitic infection caused by Schistosoma worms. Transmission occurs through contact with contaminated water containing the parasite's larvae.

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    What is Nuchal rigidity?

    The most frequent sign seen in acute bacterial meningitis. It is characterized by neck stiffness, making it difficult to flex the neck forward.

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    What is Rabies?

    A viral disease with a potential for serious complications, including encephalitis. It is spread through the bite of infected animals, primarily dogs, or contact with their saliva.

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    What is Influenza (Flu)?

    A highly infectious and potentially fatal viral disease, responsible for significant global morbidity and mortality. It causes influenza-like symptoms and can lead to severe complications like pneumonia and respiratory failure.

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    What is Onchocerciasis (River blindness)?

    A parasitic infection caused by Onchocerca volvulus worms. It is spread through the bite of infected blackflies.

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    What are Hemorrhagic Fevers?

    A group of diseases characterized by bleeding, often due to complications like disseminated intravascular coagulation (DIC). They are often caused by viruses and can progress rapidly.

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    What is Ebola virus disease?

    A serious viral disease characterized by severe fever, headache, muscle pain, and often bleeding. There is no specific treatment for Ebola virus disease, but supportive care can increase survival rates.

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    What is Leishmaniasis?

    A parasitic infection caused by various species of Leishmania parasites. The parasite infects macrophages, causing a wide range of symptoms.

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    What are the determinants of HIV/AIDS Epidemiology in Sudan?

    Characterized by a complex interplay of factors, including population density, geographical location, climate, and patterns of human movement. It also plays a role in the transmission and spread of HIV/AIDS.

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    What is the International Classification of Diseases (ICD)?

    A system used to classify diseases, injuries, and causes of death. It is revised regularly to include new diseases and conditions. It provides a standardized framework for collecting and analyzing health data.

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    What is ICD-10?

    A system used to classify diseases that assigns a unique code to each disease, injury, or cause of death. It is essential for standardizing health data collection and analysis.

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    How is Rabies virus transmitted?

    A zoonotic disease, primarily spread through the bite of infected animals, particularly dogs. However, transmission can also occur through contact with an infected animal's saliva or through contaminated materials.

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    Study Notes

    19 - Quinolones

    • Have broad spectrum against gram-positive bacteria
    • Cause ototoxicity and nephrotoxicity
    • Include cell wall synthesis
    • Good for atypical organism such as mycoplasma, chlamydia, legionella
    • Effective in anarobes

    20 - Each of the following concerning clindamycin is correct EXCEPT:

    • Has special role in treating streptococcus necrotizing fasciitis
    • Inhibits protein synthesis
    • Effective in anaerobes
    • Causes diarrhea
    • Inhibits microbial DNA synthesis

    21 - The following antibacterial drugs inhibit bacterial protein synthesis EXCEPT:

    • Lincomycin
    • Vancomycin
    • Tetracyclines
    • Aminoglycoside
    • Erythromycin

    22 - The following are factors to be considered when choosing antibacterial drugs EXCEPT:

    • Patient age
    • Patient height
    • Cost
    • The causative agent
    • Allergy

    23 - Bacterial antibiotic resistance may be:

    • Due to cell permeability changes
    • By transduction which is uptake of the extracellular DNA by bacteria
    • Rarely by plasmid conjugation
    • Due to increased production of inhibited compound
    • Due to active efflux

    24 - Systemic Inflammatory Response Syndrome

    • Heart rate is decreased
    • Respiratory rate is decreased
    • Number of red blood cells are increased
    • Body temperature increased or decreased
    • PaCO2 > 12mmHg

    25 - In sepsis:

    • Rigors are not characteristic
    • Blood pressure is high
    • Vascular tone is reduced
    • Circulation support and anti infection drugs are not essential
    • Blood culture and sensitivity, not required

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    Description

    Test your understanding of quinolones, clindamycin, and protein synthesis inhibitors in this comprehensive quiz. Delve into factors affecting antibiotic choice and explore the mechanisms behind bacterial resistance. This quiz is ideal for students studying pharmacology and microbiology.

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