Antibiotics and Pharmacokinetics
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Questions and Answers

What is the reason for contraindication of tetracyclines in children?

  • Chelation with calcium, leading to intrinsic tooth staining (correct)
  • Risk of bone weakness
  • Risk of congenital deafness
  • Risk of phototoxicity

    • Why are aminoglycosides not safe in pregnancy?

  • They can cause bone weakness
  • They can cause phototoxicity
  • They can cause intrinsic tooth staining
  • They can cause congenital deafness (correct)

    • What is the reason for avoiding aminoglycosides in renally impaired patients?

  • They can cause ototoxicity
  • They cannot penetrate CSF
  • They can cause nephrotoxicity
  • They are excreted unchanged in urine (correct)

    • What is the use of neomycin in bowel decontamination?

    <p>To decrease bacterial load in the intestine</p> Signup and view all the answers

    What is the mechanism of action of aminoglycosides?

    <p>Inhibition of bacterial protein synthesis</p> Signup and view all the answers

    Why are tetracyclines teratogenic?

    <p>They can cause developmental abnormalities</p> Signup and view all the answers

    What is the most common adverse effect associated with the use of antibiotics?

    <p>Diarrhea, nausea, and abdominal cramps</p> Signup and view all the answers

    What is the recommended prophylactic dose of Clindamycin for a penicillin allergic patient undergoing a dental procedure?

    <p>600mg orally 1 hour before the procedure</p> Signup and view all the answers

    What is the effect of taking tetracyclines with calcium on their absorption?

    <p>It reduces their absorption</p> Signup and view all the answers

    What is the mechanism of action of tetracyclines on bacterial protein synthesis?

    <p>They inhibit the bacterial protein synthesis</p> Signup and view all the answers

    What is the unique property of tetracyclines that makes them useful for treating periodontal and peri-implant disease?

    <p>Their high bioavailability in the gingival sulcus</p> Signup and view all the answers

    Why are tetracyclines not recommended for use in children and pregnant women?

    <p>Because they can cause yellow discoloration of teeth</p> Signup and view all the answers

    Which of the following macrolides is excreted in the urine?

    <p>Clarithromycin</p> Signup and view all the answers

    What is the mechanism of action of macrolides in inhibiting bacterial protein synthesis?

    <p>By binding to bacterial ribosomes</p> Signup and view all the answers

    Why is Erythromycin not preferred as a penicillin-alternative drug in severe infections or immunocompromised patients?

    <p>It is bacteriostatic, not bacteriocidal</p> Signup and view all the answers

    What is the risk of using Erythromycin in combination with an anticoagulant drug like Warfarin?

    <p>Increased risk of bleeding</p> Signup and view all the answers

    What is the advantage of macrolides in terms of excretion in patients with renal dysfunction?

    <p>They are excreted in the bile, making them safe in renal dysfunction patients</p> Signup and view all the answers

    What is the primary use of Erythromycin in dentistry?

    <p>As an alternative to penicillin in allergic patients</p> Signup and view all the answers

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