Antibiotics and Pharmacokinetics

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What is the reason for contraindication of tetracyclines in children?

Chelation with calcium, leading to intrinsic tooth staining (correct)
Risk of bone weakness
Risk of congenital deafness
Risk of phototoxicity

Why are aminoglycosides not safe in pregnancy?

They can cause bone weakness
They can cause phototoxicity
They can cause intrinsic tooth staining
They can cause congenital deafness (correct)

What is the reason for avoiding aminoglycosides in renally impaired patients?

They can cause ototoxicity
They cannot penetrate CSF
They can cause nephrotoxicity
They are excreted unchanged in urine (correct)

What is the use of neomycin in bowel decontamination?

To decrease bacterial load in the intestine (B) Signup and view all the answers

What is the mechanism of action of aminoglycosides?

Inhibition of bacterial protein synthesis (D) Signup and view all the answers

Why are tetracyclines teratogenic?

They can cause developmental abnormalities (D) Signup and view all the answers

What is the most common adverse effect associated with the use of antibiotics?

Diarrhea, nausea, and abdominal cramps (B) Signup and view all the answers

What is the recommended prophylactic dose of Clindamycin for a penicillin allergic patient undergoing a dental procedure?

600mg orally 1 hour before the procedure (C) Signup and view all the answers

What is the effect of taking tetracyclines with calcium on their absorption?

It reduces their absorption (C) Signup and view all the answers

What is the mechanism of action of tetracyclines on bacterial protein synthesis?

They inhibit the bacterial protein synthesis (A) Signup and view all the answers

What is the unique property of tetracyclines that makes them useful for treating periodontal and peri-implant disease?

Their high bioavailability in the gingival sulcus (C) Signup and view all the answers

Why are tetracyclines not recommended for use in children and pregnant women?

Because they can cause yellow discoloration of teeth (C) Signup and view all the answers

Which of the following macrolides is excreted in the urine?

Clarithromycin (C) Signup and view all the answers

What is the mechanism of action of macrolides in inhibiting bacterial protein synthesis?

By binding to bacterial ribosomes (B) Signup and view all the answers

Why is Erythromycin not preferred as a penicillin-alternative drug in severe infections or immunocompromised patients?

It is bacteriostatic, not bacteriocidal (D) Signup and view all the answers

What is the risk of using Erythromycin in combination with an anticoagulant drug like Warfarin?

Increased risk of bleeding (B) Signup and view all the answers

What is the advantage of macrolides in terms of excretion in patients with renal dysfunction?

They are excreted in the bile, making them safe in renal dysfunction patients (A) Signup and view all the answers

What is the primary use of Erythromycin in dentistry?

As an alternative to penicillin in allergic patients (A) Signup and view all the answers