18 Questions
What is the reason for contraindication of tetracyclines in children?
Chelation with calcium, leading to intrinsic tooth staining
Why are aminoglycosides not safe in pregnancy?
They can cause congenital deafness
What is the reason for avoiding aminoglycosides in renally impaired patients?
They are excreted unchanged in urine
What is the use of neomycin in bowel decontamination?
To decrease bacterial load in the intestine
What is the mechanism of action of aminoglycosides?
Inhibition of bacterial protein synthesis
Why are tetracyclines teratogenic?
They can cause developmental abnormalities
What is the most common adverse effect associated with the use of antibiotics?
Diarrhea, nausea, and abdominal cramps
What is the recommended prophylactic dose of Clindamycin for a penicillin allergic patient undergoing a dental procedure?
600mg orally 1 hour before the procedure
What is the effect of taking tetracyclines with calcium on their absorption?
It reduces their absorption
What is the mechanism of action of tetracyclines on bacterial protein synthesis?
They inhibit the bacterial protein synthesis
What is the unique property of tetracyclines that makes them useful for treating periodontal and peri-implant disease?
Their high bioavailability in the gingival sulcus
Why are tetracyclines not recommended for use in children and pregnant women?
Because they can cause yellow discoloration of teeth
Which of the following macrolides is excreted in the urine?
Clarithromycin
What is the mechanism of action of macrolides in inhibiting bacterial protein synthesis?
By binding to bacterial ribosomes
Why is Erythromycin not preferred as a penicillin-alternative drug in severe infections or immunocompromised patients?
It is bacteriostatic, not bacteriocidal
What is the risk of using Erythromycin in combination with an anticoagulant drug like Warfarin?
Increased risk of bleeding
What is the advantage of macrolides in terms of excretion in patients with renal dysfunction?
They are excreted in the bile, making them safe in renal dysfunction patients
What is the primary use of Erythromycin in dentistry?
As an alternative to penicillin in allergic patients
This quiz covers the use of antibiotics, specifically clindamycin and tetracyclines, including their pharmacokinetics and therapeutic uses. It also touches on dental uses and antibiotic-associated diarrhea.
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