Antibiotics and Bacterial Resistance: Penicillin Types
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Questions and Answers

What is the mechanism of action of β-lactam antibiotics?

  • Enhancing bacterial immune response
  • Inhibiting bacterial DNA replication
  • Inhibiting bacterial cell wall peptidoglycan synthesis (correct)
  • Inhibiting bacterial protein synthesis

What is the primary mechanism of action of cephalosporins?

  • Damaging bacterial cell membranes
  • Inhibiting peptidoglycan synthesis (correct)
  • Inhibiting DNA replication
  • Inhibiting protein synthesis

What is the primary route of elimination for β-lactam antibiotics?

  • Hepatic elimination
  • Renal elimination (correct)
  • Pulmonary elimination
  • Biliary elimination

Which of the following antibiotics is used for the treatment of Enterococcus faecalis infections?

<p>Second-generation cephalosporin (B)</p> Signup and view all the answers

Which type of β-lactamase is NOT inhibited by avibactam?

<p>Metallo-β-lactamases (A)</p> Signup and view all the answers

What is the primary route of elimination for cephalosporins?

<p>Renal elimination (D)</p> Signup and view all the answers

What is the route of administration for penicillin V?

<p>Oral (A)</p> Signup and view all the answers

Which of the following bacteria is sensitive to first-generation cephalosporins?

<p>Staphylococcus aureus (A)</p> Signup and view all the answers

What is the genus of the bacteria that causes meningitis, which is susceptible to penicillin?

<p>Streptococcus (A)</p> Signup and view all the answers

What is the primary adverse effect of cephalosporins?

<p>Hypersensitivity reactions (B)</p> Signup and view all the answers

Which of the following antibiotics is a combination of a penicillin and a β-lactamase inhibitor?

<p>Ampicillin/sulbactam (D)</p> Signup and view all the answers

What is the main problem associated with the use of bacterial meningitis treatment?

<p>Bacterial resistance (A)</p> Signup and view all the answers

Which type of penicillin is effective against methicillin-resistant S. aureus (MRSA)?

<p>None of the above (D)</p> Signup and view all the answers

What is the characteristic of Ureidopenicillins?

<p>High activity against Pseudomonas and gram-negative microorganisms (D)</p> Signup and view all the answers

Which of the following is a β-lactamase inhibitor similar in structure to clavulanic acid?

<p>Sulbactam (C)</p> Signup and view all the answers

What is the main advantage of piperacillin over carbenicillin?

<p>More activity against Pseudomonas and less active against gram-positive cocci (B)</p> Signup and view all the answers

Which of the following is not a characteristic of Antistaphylococcal penicillins?

<p>Effective against methicillin-resistant S. aureus (MRSA) (B)</p> Signup and view all the answers

What is the primary route of excretion for most cephalosporins?

<p>Renal (B)</p> Signup and view all the answers

Which of the following cephalosporins can penetrate the blood-brain barrier?

<p>Generation III cephalosporins (D)</p> Signup and view all the answers

What is the main mechanism of resistance to cephalosporins during therapy?

<p>Selection of isolates with de-repression of bacterial chromosomal β-lactamases (C)</p> Signup and view all the answers

Cephalosporins containing methythiotetrazole are associated with which adverse effect?

<p>Hypoprothrombinemia (C)</p> Signup and view all the answers

What is the approximate percentage of patients allergic to penicillins who also exhibit cross-hypersensitivity to cephalosporins?

<p>5-10% (B)</p> Signup and view all the answers

Which of the following cephalosporins is not marketed in the US?

<p>Not specified in the text (C)</p> Signup and view all the answers

What is a characteristic of aminoglycosides in terms of absorption?

<p>They are highly polar and not absorbed through the GI tract (B)</p> Signup and view all the answers

Which of the following aminoglycosides is indicated for infections due to gentamicin-resistant Gram-negative pathogens?

<p>Amikacin (C)</p> Signup and view all the answers

What is a common adverse effect of aminoglycosides?

<p>Nephrotoxicity (A)</p> Signup and view all the answers

Fluoroquinolones are primarily active against which type of pathogens?

<p>Gram-negative pathogens (B)</p> Signup and view all the answers

Which of the following fluoroquinolones has substantial activity against P. aeruginosa?

<p>Ciprofloxacin and Levofloxacin (C)</p> Signup and view all the answers

What is the primary mechanism of excretion for aminoglycosides?

<p>Glomerular filtration (A)</p> Signup and view all the answers

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