Antibiotics

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Questions and Answers

Who first discovered that colonies of the bacterium Staphylococcus aureus failed to grow in the area contaminated by Penicillium notatum?

  • Alexander Fleming (correct)
  • Howard Florey
  • Ernst Chain
  • Pfizer

In what year was Penicillin made available orally to the public without prescription?

  • 1950
  • 1945 (correct)
  • 1940
  • 1942

Which bacteria produce about 70% of known antibiotics?

  • Streptomyces (correct)
  • Penicillium
  • Staphylococcus
  • Pfizer

Who successfully achieved mass production of Penicillin using deep-tank fermentation techniques?

<p>Pfizer (B)</p> Signup and view all the answers

Who were jointly awarded the Nobel Prize in Physiology & Medicine for the discovery of Penicillin?

<p>Fleming, Florey, and Chain (B)</p> Signup and view all the answers

In what year was the Nobel Prize in Physiology & Medicine awarded for the discovery of Penicillin?

<p>1950 (A)</p> Signup and view all the answers

Which mold was first used for the production of Penicillin?

<p>Penicillium notatum (B)</p> Signup and view all the answers

Which organism was found to produce 100 times more Penicillin than the original Penicillium mould (notatum)?

<p>Penicillium chrysogenum (D)</p> Signup and view all the answers

In what year was the original Penicillium mould (notatum) found to produce less than 10 units per ml of broth?

<p>1943 (C)</p> Signup and view all the answers

Who initiated human trials for the purified penicillin mold by injecting it into live mice?

<p>Howard Florey (A)</p> Signup and view all the answers

In what year did the industrial evolution of penicillin production begin?

<p>1929 (D)</p> Signup and view all the answers

Which company achieved mass production of Penicillin using deep-tank fermentation techniques in 1942?

<p>Pfizer (D)</p> Signup and view all the answers

What is the method used to identify suitable antibiotics?

<p>The Disk-Diffusion Method (A)</p> Signup and view all the answers

What is the mechanism of action of methicillin?

<p>Inhibiting a protein used by bacteria in their cell walls (B)</p> Signup and view all the answers

What is the consequence of exposure to methicillin for MRSA strains?

<p>More likely to survive and reproduce (A)</p> Signup and view all the answers

Which method is used to find new antibiotics?

<p>Teixobactin discovery (C)</p> Signup and view all the answers

What is the main reason for the emergence of antibiotic resistance?

<p>Misuse of antibiotics (A)</p> Signup and view all the answers

What is the effect of combining two antibiotics in synergism?

<p>The effect of two drugs together is greater than the effect of either alone (A)</p> Signup and view all the answers

What is the role of X-irradiation in strain selection?

<p>300-500 colonies (C)</p> Signup and view all the answers

What is the significance of S. aureus becoming resistant to methicillin in 1961?

<p>Two years after it was first widely used (A)</p> Signup and view all the answers

What is the main reason for the resistance to antibiotics in animal feed?

<p>Using antibiotics in animal feed (A)</p> Signup and view all the answers

What is the consequence of using outdated or weakened antibiotics?

<p>Selects for resistance mutants (D)</p> Signup and view all the answers

What is the action of broad-spectrum penicillins?

<p>Broader range of activity (D)</p> Signup and view all the answers

What is the role of chemical mutagenesis in strain selection?

<p>1500-2000 colonies (B)</p> Signup and view all the answers

Who was the first to discover that colonies of the bacterium Staphylococcus aureus failed to grow in the area contaminated by Penicillium notatum?

<p>Alexander Fleming (C)</p> Signup and view all the answers

In what year was Penicillin made available orally to the public without prescription?

<p>1945 (A)</p> Signup and view all the answers

Who successfully achieved mass production of Penicillin using deep-tank fermentation techniques?

<p>Pfizer (C)</p> Signup and view all the answers

Who initiated human trials for the purified penicillin mold by injecting it into live mice?

<p>Howard Florey (C)</p> Signup and view all the answers

In what year was the Nobel Prize in Physiology & Medicine awarded for the discovery of Penicillin?

<p>1940 (A)</p> Signup and view all the answers

Which mold was first used for the production of Penicillin?

<p>Penicillium notatum (A)</p> Signup and view all the answers

In what year was the original Penicillium mould (notatum) found to produce less than 10 units per ml of broth?

<p>1943 (D)</p> Signup and view all the answers

Who were jointly awarded the Nobel Prize in Physiology & Medicine for the discovery of Penicillin?

<p>Alexander Fleming, Howard Florey, and Ernst Chain (D)</p> Signup and view all the answers

What are antibiotics?

<p>Compounds produced by microorganisms that kill or inhibit the growth of other microorganisms (A)</p> Signup and view all the answers

Which bacteria produce about 70% of known antibiotics?

<p>Streptomyces bacteria (B)</p> Signup and view all the answers

What was the yield of the original Penicillium mould (notatum) in 1929?

<p>2-20 units/mL (D)</p> Signup and view all the answers

Who discovered that Penicillin was first produced by Penicillium notatum?

<p>Alexander Fleming (D)</p> Signup and view all the answers

What is the mechanism of action of Teixobactin, a new class of antibiotics?

<p>Inhibition of cell wall synthesis (A)</p> Signup and view all the answers

What is the main reason for the emergence of methicillin-resistant Staphylococcus aureus (MRSA)?

<p>Exposure to methicillin selecting for survival and reproduction (B)</p> Signup and view all the answers

What is the role of the ichip in antibiotic discovery?

<p>Opening new environments for antibiotic discovery (B)</p> Signup and view all the answers

What is the effect of using antibiotics for the common cold and other inappropriate conditions?

<p>Misuse leading to selection for resistance mutants (C)</p> Signup and view all the answers

What is the consequence of failing to complete the prescribed antibiotic regimen?

<p>Selection for resistance mutants (D)</p> Signup and view all the answers

What is the significance of the combination of penicillin with potassium clavulanate (an inhibitor of penicillinase)?

<p>Overcoming resistance due to penicillinase production (A)</p> Signup and view all the answers

What is the role of X-irradiation in strain selection?

<p>Inducing mutations for strain selection (B)</p> Signup and view all the answers

What is the action of broad-spectrum penicillins?

<p>Inhibition of cell wall synthesis in bacteria (A)</p> Signup and view all the answers

What is the main reason for the resistance to antibiotics in animal feed?

<p>Misuse of antibiotics in animal feed (C)</p> Signup and view all the answers

What is the consequence of exposure to outdated or weakened antibiotics?

<p>Selection for resistance mutants (A)</p> Signup and view all the answers

What is the method used to identify suitable antibiotics?

<p>The Disk-Diffusion Method (B)</p> Signup and view all the answers

What is the effect of combining two antibiotics in synergism?

<p>The effect of two drugs together is greater than the effect of either alone (C)</p> Signup and view all the answers

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