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Questions and Answers
What is the mechanism of action of chloramphenicol?
What is the mechanism of action of chloramphenicol?
- Inhibits microbial cell wall synthesis
- Inhibits microbial RNA synthesis
- Inhibits microbial protein synthesis (correct)
- Inhibits microbial DNA synthesis
What is the spectrum of antimicrobial activity of chloramphenicol?
What is the spectrum of antimicrobial activity of chloramphenicol?
- Active against both gram-positive and gram-negative organisms (correct)
- Not active against any organisms
- Active against gram-positive organisms only
- Active against gram-negative organisms only
What is the cause of clinically significant resistance to chloramphenicol?
What is the cause of clinically significant resistance to chloramphenicol?
- Decreased permeability of the microbial cell membrane to the drug
- Increased efflux of the drug from the microbial cell
- All of the above
- Inactivation of the drug by microbial enzymes (correct)
