Antibiotic Resistance Mechanisms Quiz
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Questions and Answers

What is the main cause of resistance to rifampin?

  • Alteration in the beta subunit of RNA polymerase (correct)
  • Horizontal gene transfer of resistance gene
  • Changes in the inhA regulatory regions
  • Mutations in the katG gene

Which of the following enzymes converts INH to its biologically active form?

  • Penicillinase
  • Beta-lactamase
  • Catalase peroxidase (correct)
  • Transpeptidase

MDR TB is characterized by resistance to which two potent TB drugs?

  • Pyrazinamide and Ethionamide
  • Amikacin and Capreomycin
  • Rifampin and INH (correct)
  • Streptomycin and Ethambutol

Which mechanism of resistance involves the transfer of plasmids or transposons between bacteria?

<p>Horizontal gene transfer (D)</p> Signup and view all the answers

In antibiotic resistance, which process involves bacteriophage transfer genes from one cell to another?

<p>Transduction (A)</p> Signup and view all the answers

Which of the following factors contributes to antibiotic resistance in the environment?

<p>Environmental factors (D)</p> Signup and view all the answers

What is the specific mechanism by which MRSA bacteria develop resistance to beta-lactam antibiotics?

<p>Altered cell wall precursors (D)</p> Signup and view all the answers

In the context of antibiotic resistance mechanisms, what does the mecA gene encode for?

<p>Alternative penicillin binding protein 2a (PBP-2a) (C)</p> Signup and view all the answers

What is the role of the rpoB gene in the development of drug resistance in MDR-TB?

<p>Altering the target of rifampicin (B)</p> Signup and view all the answers

Which bacterial species is known for its ability to develop quinolone resistance through DNA gyrase mutations?

<p>Pseudomonas aeruginosa (D)</p> Signup and view all the answers

How does Altering Target of the antibiotic contribute to vancomycin resistance?

<p>Altered cell wall precursors (D)</p> Signup and view all the answers

What is the main role of the mecA gene in conferring antibiotic resistance in bacteria?

<p>Altering antibiotic target (A)</p> Signup and view all the answers

What is the main function of efflux mechanisms in antibiotic resistance?

<p>Limiting the entry of antibiotics into bacterial cells (D)</p> Signup and view all the answers

Which of the following is NOT a mechanism of antibiotic resistance?

<p>Intrinsic permeability (B)</p> Signup and view all the answers

What role do biofilms play in antibiotic resistance?

<p>Providing a protective barrier for bacteria (B)</p> Signup and view all the answers

How do bacteria with enzymatic inactivation resistance mechanism work against antibiotics?

<p>Destroying antibiotics through enzymatic reactions (A)</p> Signup and view all the answers

What does altering the drug target site involve in antibiotic resistance?

<p>Preventing the binding of antibiotics to their targets (B)</p> Signup and view all the answers

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