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Antibiotic Resistance Mechanisms Quiz

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Questions and Answers

What is the main cause of resistance to rifampin?

Alteration in the beta subunit of RNA polymerase (correct)

Horizontal gene transfer of resistance gene

Changes in the inhA regulatory regions

Mutations in the katG gene

Which of the following enzymes converts INH to its biologically active form?

Penicillinase

Beta-lactamase

Catalase peroxidase (correct)

Transpeptidase

MDR TB is characterized by resistance to which two potent TB drugs?

Pyrazinamide and Ethionamide

Amikacin and Capreomycin

Rifampin and INH (correct)

Streptomycin and Ethambutol

Which mechanism of resistance involves the transfer of plasmids or transposons between bacteria?

Horizontal gene transfer Signup and view all the answers

In antibiotic resistance, which process involves bacteriophage transfer genes from one cell to another?

Transduction Signup and view all the answers

Which of the following factors contributes to antibiotic resistance in the environment?

Environmental factors Signup and view all the answers

What is the specific mechanism by which MRSA bacteria develop resistance to beta-lactam antibiotics?

Altered cell wall precursors Signup and view all the answers

In the context of antibiotic resistance mechanisms, what does the mecA gene encode for?

Alternative penicillin binding protein 2a (PBP-2a) Signup and view all the answers

What is the role of the rpoB gene in the development of drug resistance in MDR-TB?

Altering the target of rifampicin Signup and view all the answers

Which bacterial species is known for its ability to develop quinolone resistance through DNA gyrase mutations?

Pseudomonas aeruginosa Signup and view all the answers

How does Altering Target of the antibiotic contribute to vancomycin resistance?

Altered cell wall precursors Signup and view all the answers

What is the main role of the mecA gene in conferring antibiotic resistance in bacteria?

Altering antibiotic target Signup and view all the answers

What is the main function of efflux mechanisms in antibiotic resistance?

Limiting the entry of antibiotics into bacterial cells Signup and view all the answers

Which of the following is NOT a mechanism of antibiotic resistance?

Intrinsic permeability Signup and view all the answers

What role do biofilms play in antibiotic resistance?

Providing a protective barrier for bacteria Signup and view all the answers

How do bacteria with enzymatic inactivation resistance mechanism work against antibiotics?

Destroying antibiotics through enzymatic reactions Signup and view all the answers

What does altering the drug target site involve in antibiotic resistance?

Preventing the binding of antibiotics to their targets Signup and view all the answers