17 Questions
What is the main cause of resistance to rifampin?
Alteration in the beta subunit of RNA polymerase
Which of the following enzymes converts INH to its biologically active form?
Catalase peroxidase
MDR TB is characterized by resistance to which two potent TB drugs?
Rifampin and INH
Which mechanism of resistance involves the transfer of plasmids or transposons between bacteria?
Horizontal gene transfer
In antibiotic resistance, which process involves bacteriophage transfer genes from one cell to another?
Transduction
Which of the following factors contributes to antibiotic resistance in the environment?
Environmental factors
What is the specific mechanism by which MRSA bacteria develop resistance to beta-lactam antibiotics?
Altered cell wall precursors
In the context of antibiotic resistance mechanisms, what does the mecA gene encode for?
Alternative penicillin binding protein 2a (PBP-2a)
What is the role of the rpoB gene in the development of drug resistance in MDR-TB?
Altering the target of rifampicin
Which bacterial species is known for its ability to develop quinolone resistance through DNA gyrase mutations?
Pseudomonas aeruginosa
How does Altering Target of the antibiotic contribute to vancomycin resistance?
Altered cell wall precursors
What is the main role of the mecA gene in conferring antibiotic resistance in bacteria?
Altering antibiotic target
What is the main function of efflux mechanisms in antibiotic resistance?
Limiting the entry of antibiotics into bacterial cells
Which of the following is NOT a mechanism of antibiotic resistance?
Intrinsic permeability
What role do biofilms play in antibiotic resistance?
Providing a protective barrier for bacteria
How do bacteria with enzymatic inactivation resistance mechanism work against antibiotics?
Destroying antibiotics through enzymatic reactions
What does altering the drug target site involve in antibiotic resistance?
Preventing the binding of antibiotics to their targets
Test your knowledge on antibiotic resistance mechanisms with this quiz by Dr I. Gobe from the School of Allied Health Professions at the University of Botswana. Learn about how bacteria become antibiotic resistant and the different categories of antimicrobial resistance mechanisms.
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