Antibiotic Resistance and Usage Quiz

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Questions and Answers

What is a primary cause of antibiotic resistance in bacteria?

  • High fluid intake
  • Natural selection of resistant strains (correct)
  • Increased hand hygiene
  • Overuse of vaccines

Which of the following is NOT a mechanism through which bacteria develop antibiotic resistance?

  • Increased immune response (correct)
  • Inactivation of the antibiotic
  • Modification of target structures
  • Decreased antibiotic permeability

What effect does antibiotic therapy have on non-target bacteria in the body?

  • Eliminates all bacteria, including beneficial ones (correct)
  • Has no effect on non-target bacteria
  • Promotes growth of beneficial bacteria
  • Only targets harmful bacteria

Which of the following describes an incorrect practice of antibiotic use by clinicians?

<p>Prescribing antibiotics without adequate knowledge of infections (B)</p> Signup and view all the answers

Which factor is LEAST likely to cause the spread of antibiotic resistance?

<p>Increased vaccination rates (A)</p> Signup and view all the answers

What is the common property shared by all antibiotics?

<p>Selective toxicity towards invading organisms (B)</p> Signup and view all the answers

Which type of drug would be classified as an antiviral?

<p>Zidovudine (D)</p> Signup and view all the answers

What distinguishes a bactericidal agent from a bacteriostatic one?

<p>Bactericidal agents kill the organisms directly (D)</p> Signup and view all the answers

Which of the following best describes the spectrum of an antibiotic?

<p>The range of bacteria the antibiotic can kill or inhibit (A)</p> Signup and view all the answers

Which antimicrobial agents can be classified as bactericidal?

<p>β-lactams, aminoglycosides (C)</p> Signup and view all the answers

What is a common reason for using antibiotics in seriously ill patients even without knowing the pathogen?

<p>It is impossible to collect a culture (C)</p> Signup and view all the answers

Which statement is true regarding the duration of antibiotic treatment?

<p>Depends on disease severity and culture results (A)</p> Signup and view all the answers

What is a potential risk factor for prescribing antibiotics?

<p>Age and immune system deficiency (A)</p> Signup and view all the answers

Which route of administration is NOT commonly used for antibiotics?

<p>Transdermal (B)</p> Signup and view all the answers

Why is bacterial resistance considered a growing problem?

<p>Daily emergence of drug-resistant strains (D)</p> Signup and view all the answers

What is one primary reason for associating different antibiotics?

<p>To prevent resistance and achieve a synergistic effect (C)</p> Signup and view all the answers

Which factor does NOT typically influence the choice of antibiotics?

<p>Patient's psychological state (A)</p> Signup and view all the answers

What is the purpose of conducting serial cultures during antibiotic treatment?

<p>To monitor the permanence of the microorganism at the infection site (A)</p> Signup and view all the answers

Which type of bacteria is resistant to penicillinases?

<p>Staphylococcus (MSSA) (C)</p> Signup and view all the answers

What is the main use of amoxicillin-clavulanic acid?

<p>Managing respiratory infections from betalactamase producers (B)</p> Signup and view all the answers

Which of the following antibiotics is used for treating cellulitis?

<p>Amoxicillin (B)</p> Signup and view all the answers

What is the primary indication for penicillin G?

<p>Respiratory infections from Streptococcus pyogenes (D)</p> Signup and view all the answers

Which class of antibiotics includes ampicillin?

<p>Aminopenicillins (D)</p> Signup and view all the answers

What is the primary mechanism of action for lincosamides?

<p>Inhibition of protein synthesis (D)</p> Signup and view all the answers

Which of the following antibiotics is NOT effective against aerobic gram-negative bacteria?

<p>Clindamycin (B)</p> Signup and view all the answers

What is the most significant adverse reaction associated with clindamycin use?

<p>Pseudo membranous colitis (B)</p> Signup and view all the answers

Which of the following describes the pharmacokinetic property of clindamycin?

<p>High concentration in bone (B)</p> Signup and view all the answers

What is the main indication for using difficile in vitro?

<p>Clostridium difficile infection with high recurrence risk (C)</p> Signup and view all the answers

Which condition can clindamycin be used as an alternative treatment for?

<p>Penicillin-allergic patients with oral infections (D)</p> Signup and view all the answers

Resistance to lincosamides is similar to which antibiotic?

<p>Erythromycin (B)</p> Signup and view all the answers

What gastrointestinal side effect is reported in 30-35% of patients taking clindamycin?

<p>Diarrhea (B)</p> Signup and view all the answers

Which condition represents a deep or systemic fungal infection?

<p>Candidiasis (C)</p> Signup and view all the answers

What adverse reaction is commonly associated with Amphotericin B treatment?

<p>Reversible nephrotoxicity (C)</p> Signup and view all the answers

What is a key consideration in treating fungal infections in immunocompromised patients?

<p>Drug resistance (C)</p> Signup and view all the answers

Which antifungal agent binds to sterols in the fungal cell membrane, forming channels that disrupt membrane permeability?

<p>Nystatin (B)</p> Signup and view all the answers

What is one of the mechanisms of action of azole antifungals?

<p>Blocking ergosterol synthesis (A)</p> Signup and view all the answers

Which classification of antifungal affects cell wall synthesis?

<p>Echinocandins (C)</p> Signup and view all the answers

What factor does not directly influence the treatment of fungal infections?

<p>Popular culture practices (A)</p> Signup and view all the answers

Which formulation of Amphotericin B is associated with less nephrotoxicity?

<p>Lipidic formulations (B)</p> Signup and view all the answers

Flashcards

Antibiotic

A substance that kills or inhibits the growth of microorganisms, specifically bacteria.

Spectrum (of an antibiotic)

The range of organisms that an antibiotic is effective against.

Bactericidal antibiotic

An antibiotic that kills bacteria.

Bacteriostatic antibiotic

An antibiotic that inhibits the growth and replication of bacteria.

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Selective Toxicity

The ability of an antibiotic to harm invading microorganisms more than human cells.

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Antibiotic Misuse

Using antibiotics incorrectly, such as not taking the full course or using them for non-bacterial infections.

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Antibiotic Resistance

Bacteria that have evolved to survive antibiotics, making them ineffective.

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Spread of Resistance

When resistant bacteria multiply unchecked because the antibiotics haven't killed them.

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Empirical treatment

Using antibiotics without knowing the specific bacteria causing the infection. This is based on clinical judgment and might not be the most effective approach.

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Minimum Inhibitory Concentration (MIC)

The lowest concentration of an antibiotic that inhibits the growth of a bacteria.

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Bactericidal

The ability of an antibiotic to kill bacteria.

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Bacteriostatic

The ability of an antibiotic to stop bacteria from multiplying.

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Antibiogram

A test that measures a bacteria's susceptibility to different antibiotics. Helps doctors choose the most effective antibiotic.

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Antibiotic association

Combining multiple antibiotics with different mechanisms of action to increase effectiveness against infections.

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Bacterial resistance

The development of resistance to antibiotics in bacteria, making them harder to treat.

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Routes of administration

Different routes of administration for antibiotics: oral, rectal, intravenous, continuous, intramuscular, intrathecal, inhaled.

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Penicillinase-resistant penicillin

A type of penicillin that is resistant to penicillinase enzymes produced by bacteria.

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Cloxacillin

A specific type of penicillinase-resistant penicillin used to treat infections caused by Staphylococcus aureus (MSSA).

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Aminopenicillins

A group of penicillin antibiotics used to treat infections by gram-positive cocci, including Streptococcus pyogenes, except Staphylococcus aureus.

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Anti-pseudomonal penicillin (e.g., Piperacillin)

A type of penicillin specifically designed to combat Pseudomonas aeruginosa, a resistant bacteria.

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Penicillin with beta-lactamase inhibitor

A class of penicillin drugs that are combined with a beta-lactamase inhibitor (e.g., clavulanic acid) to overcome bacterial resistance.

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Superficial Mycoses

Fungal infections that affect the skin, hair, and nails.

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Deep or Systemic Mycoses

Fungal infections that affect deeper tissues and organs, often in immunocompromised individuals.

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Ringworm

A common example of a superficial mycosis caused by dermatophyne fungi.

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Aspergillosis

An example of a deep fungal infection that can affect the lungs and other organs.

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Polyene Antifungals

A group of antifungal drugs that disrupt the fungal cell membrane's permeability.

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Amphotericin B

A common polyene antifungal that is effective against many serious fungal infections.

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Nephrotoxicity

Amphotericin B can cause this serious side effect, especially in the early stages of treatment.

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Azoles

A group of antifungal drugs that inhibit the synthesis of ergosterol, a key component of the fungal cell membrane.

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Lincosamide

A type of antibiotic that inhibits protein synthesis by binding to the 50S subunit of the bacterial ribosome.

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Pseudomembranous Colitis

A rare but serious complication of antibiotic treatment, especially clindamycin, characterized by inflammation of the colon due to a bacteria called Clostridium difficile.

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Antibacterial Spectrum

The ability of an antibiotic to affect a specific range of bacteria, indicating which types of bacteria it can kill or inhibit.

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Fidaxomicin

A type of antibiotic used to treat Clostridium difficile infection, especially if the risk of recurrence is high.

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C. difficile-Targeted Antibiotic

A type of antibiotic that targets a specific type of bacteria, Clostridium difficile, which often causes antibiotic-associated diarrhea.

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Good Oral Absorption

The ability of an antibiotic to be easily absorbed by the body after oral administration.

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Hepatic Metabolism

The process of breaking down chemicals, like drugs, in the body, often occurring in the liver.

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Study Notes

General Principles of Use of Antibacterial Drugs

  • Antibiotic - an anti-infective compound produced by microorganisms or synthesized chemically
  • Selective toxicity - the antibiotic's toxicity is greater towards invading organisms than towards human host tissues
  • Spectrum - the range of pathogens affected by the antibiotic (antibacterial, antiviral, antifungal, or antiparasitic)

Bactericide / Bacteriostatic

  • Bactericidal - agents that kill the microorganism
  • Bacteriostatic - agents that inhibit bacterial growth and replication
  • Action - depends on the mechanism of action, concentration at the site of action, and the size of the inoculum

Type of Antibiotic Treatment

  • Empirical - chosen without knowing the specific germ causing the infection
  • Specific - chosen after identifying the germ and knowing the antibiogram

Antibacterial Activity

  • Susceptibility - how susceptible the bacterial strain is to the antibiotic
  • Types - susceptible, intermediate, or resistant
  • Quantification - using methods like diffusion and dilution techniques

MIC (Minimum Inhibitory Concentration)

  • The lowest concentration of antibiotic capable of inhibiting the growth of microorganisms in a given medium after a certain period of incubation.

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