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Antiandrogena Secundae Generationis

Antiandrogena Secundae Generationis

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Questions and Answers

Quod medicamentum contra cancrum prostatae, cum enzalutamido comparatum, maiorem incidentiam exanthematis habet?

Enzalutamidum
Darolutamidum
Apalutamidum (correct)
Nullum ex suprascriptis

Si aegrotus enzalutamidum accipit, quae cytochroma P450 inducuntur?

CYP2C9
CYP3A4/5 (correct)
CYP2C8
CYP1A2

Quod medicamentum contra cancrum prostatae, cum cibo accipiendum est?

Darolutamidum (correct)
Enzalutamidum
Apalutamidum
Bicalutamidum

Si doses darolutamidi aptandae sint propter insufficientiam renalem, quo gradu depurationis creatininae dosis reducenda est?

<p>CrCl 15-29 mL/min (D)</p> Signup and view all the answers

Quod medicamentum inhibitionem gycoproteini-P (P-gp) ostendit?

<p>Enzalutamidum (A)</p> Signup and view all the answers

Quod e medicamentis enumeratis CYP2C19 inducit?

<p>Apalutamidum (C)</p> Signup and view all the answers

Quod effectus adversus cum omnibus agentibus secundae generationis antiandrogenis coniungitur?

<p>Hypertension (B)</p> Signup and view all the answers

Quod medicamentum substratum et inductor CYP3A4 est?

<p>Et Apalutamidum et Darolutamidum (D)</p> Signup and view all the answers

Quod e medicamentis enumeratis debilem inductionem CYP3A4 habet?

<p>Darolutamidum (D)</p> Signup and view all the answers

Quod medicamentum inhibitionem BCRP (Breast Cancer Resistance Protein) ostendit?

<p>Darolutamidum (D)</p> Signup and view all the answers

Aegrotus warfarinum accipit. Quod medicamentum contra cancrum prostatae interactionem medicamenti habet quae dosis warfarini aptationem postulat?

<p>Apalutamidum (B)</p> Signup and view all the answers

Quod e medicamentis enumeratis interactionem cum rosuvastatino habet?

<p>Darolutamidum (B)</p> Signup and view all the answers

Si aegrotus statinas accipit, quod medicamentum contra cancrum prostatae monitorium effectuum adversorum e statinis necessitat?

<p>Omnes suprascripti (C)</p> Signup and view all the answers

Quod e medicamentis enumeratis adhiberi potest ad tractandum m0CRPC?

<p>Et Apalutamidum et Darolutamidum (A)</p> Signup and view all the answers

Quomodo enzalutamidum se comparat ad primae generationis anti-androgena?

<p>Validorem inhibitionem receptorum androgenorum habet. (A)</p> Signup and view all the answers

Quod medicamentum cum clopidogrelo interagit?

<p>Apalutamidum (B)</p> Signup and view all the answers

Aegrotus inhibitorem basis protonicae accipit (PPI). Quod medicamentum contra cancrum prostatae aptationem dosis PPI necessitat?

<p>Et Enzalutamidum et Apalutamidum (C)</p> Signup and view all the answers

Si aegrotus morbum comitialem habet, quae medicamenta caute adhibenda sunt?

<p>Omnes suprascripti (C)</p> Signup and view all the answers

Quod effectus adversus peculiare apalutamidi est sed cum aliis medicamentis non coniungitur?

<p>Hypothyroidismus (A)</p> Signup and view all the answers

Flashcards

Antiandrogena Secundae Generationis

Agens hormonales quae receptores androgenicos fortius inhibent quam antiandrogena primae generationis.

Enzalutamidum Dosis

160mg per os (PO) cotidie.

Enzalutamidi Effectus Adversi

Fatigatio, casus, fracturae, hypertensio, comitiales impetus.

Enzalutamidum Interactiones Medicamentorum (DDI)

Substratum CYP3A4/5, CYP2C8; inhibet P-gp; inducit CYP3A4.

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Apalutamidum Dosis

240mg per os (PO) cotidie.

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Apalutamidi Effectus Adversi

Temeritas, fracturae, fatigatio, hypothyroidismus, hypertensio, impetus.

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Apalutamidum Interactiones Medicamentorum (DDI)

Substratum CYP3A4, CYP2C8; inducit CYP3A4, CYP2C19.

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Darolutamidum Dosis

600mg bis in die (BID) cum cibo. Si CrCl 15-29: 300mg per os (PO) bis in die.

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Darolutamidi Effectus Adversi

Fatigatio, hypertensio, temeritas, impetus.

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Darolutamidum Interactiones Medicamentorum (DDI)

Substratum CYP3A4, P-gp; inhibet BCRP; inducit CYP3A4 (weak).

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Study Notes

Agentes antiandrogeni secundi generationis validiorem inhibitionem in receptore androgenico exhibent comparati cum antiandrogenis primae generationis.

Enzalutamidum

Indicatio: m1CSPC, m1CRPC, m0CSPC
Posologia: 160mg per os quotidie.
Effectus adversi: Lassitudo, casus, fracturae, hypertensio, convulsiones.
Interactiones medicamentorum (DDI):
- Substratum: CYP3A4/5, CYP2C8
- Inhibit P-gp.
- Inducit: CYP3A4
- Exempla: statinae, DOACs, CCBs, opioida, PPIs.

Apalutamidum

Indicatio: m1CSPC, m0CRPC
Posologia: 240mg per os quotidie.
Effectus adversi: Temeritas cutis, fracturae, lassitudo, hypothyroidismus, hypertensio, convulsiones.
Interactiones medicamentorum (DDI):
- Substratum: CYP3A4, CYP2C8
- Inducit: CYP3A4, CYP2C19
- Exempla: statinae, DOACs, clopidogrel, warfarina, CCBs, opioida, PPIs, citalopramum.

Darolutamidum

Indicatio: m0CRPC
Posologia: 600mg bis in die cum cibo. Si CrCl 15-29: 300mg per os bis in die.
Effectus adversi: Lassitudo, hypertensio, temeritas cutis, convulsiones.
Interactiones medicamentorum (DDI):
- Substratum: CYP3A4, P-gp
- Inhibit BCRP.
- Inducit: CYP3A4 (infirme)
- Exempla: Rosuvastatina.

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