Podcast
Questions and Answers
What antimicrobials belong in the family Ansamycins?
What antimicrobials belong in the family Ansamycins?
Rifampin
What is rifampin also called?
What is rifampin also called?
Rifampicin
What is the ranking Ansamycins in the WHO list of medically important antimicrobials ?
What is the ranking Ansamycins in the WHO list of medically important antimicrobials ?
Critically important antimicrobial
The use of Ansamycins SHOULD NOT be used in food producing animals
The use of Ansamycins SHOULD NOT be used in food producing animals
Which characteristic of rifampin allows it to easily penetrate cell membranes?
Which characteristic of rifampin allows it to easily penetrate cell membranes?
Rifampin is stable in which type of pH environment?
Rifampin is stable in which type of pH environment?
Why are rifampin dosages adjusted when administered with feed?
Why are rifampin dosages adjusted when administered with feed?
Rifampin has ______________ volume of distribution (Vd) and is approximately ______ percent bound to plasma proteins?
Rifampin has ______________ volume of distribution (Vd) and is approximately ______ percent bound to plasma proteins?
Rifampin is able to penetrate all of the following tissues EXCEPT:
Rifampin is able to penetrate all of the following tissues EXCEPT:
Rifampin is primarily metabolized by which organ?
Rifampin is primarily metabolized by which organ?
What is a key consequence of rifampin being a hepatic enzyme inducer?
What is a key consequence of rifampin being a hepatic enzyme inducer?
Rifampin exerts its antibacterial effect by inhibiting which bacterial enzyme?
Rifampin exerts its antibacterial effect by inhibiting which bacterial enzyme?
How does rifampin effectively target intracellular bacteria?
How does rifampin effectively target intracellular bacteria?
Rifampin penetrates the outer membrane of Gram __________ bacteria more easily than gram __________ bacteria (Type out whole sentence)
Rifampin penetrates the outer membrane of Gram __________ bacteria more easily than gram __________ bacteria (Type out whole sentence)
What type of activity does rifampin exhibit?
What type of activity does rifampin exhibit?
Rifampin is reported bactericidal or bacteriostatic
Rifampin is reported bactericidal or bacteriostatic
How does rifampin interact with P-glycoprotein transporters? (Antagonistic effect)
How does rifampin interact with P-glycoprotein transporters? (Antagonistic effect)
Rifampin induces hepatic and intestinal cytochrome P450 enzymes, which results in:
Rifampin induces hepatic and intestinal cytochrome P450 enzymes, which results in:
What is the antagonistic effect of rifampin’s microsomal enzyme induction and which drugs can it affect?
What is the antagonistic effect of rifampin’s microsomal enzyme induction and which drugs can it affect?
Which drug(s) is rifampin antagonistic with?
Which drug(s) is rifampin antagonistic with?
What are the three types of (general) adverse affects noted with Ansamycins?
What are the three types of (general) adverse affects noted with Ansamycins?
One of the side effects of the administration of rifampin is that it stains everything red that it’s in contact with. Which of the following may be discolored red-orange?
One of the side effects of the administration of rifampin is that it stains everything red that it’s in contact with. Which of the following may be discolored red-orange?
What is the spectrum of activity of Ansamycins?
What is the spectrum of activity of Ansamycins?
Other antimicrobials are usually administered with rifampin in order to prevent _________________________
Other antimicrobials are usually administered with rifampin in order to prevent _________________________
Which of the following describes the human formulation of ansamycins?
Which of the following describes the human formulation of ansamycins?
Rifampin is especially active in the treatment of infections caused by which bacteria?
Rifampin is especially active in the treatment of infections caused by which bacteria?
Rifampin is active in (acidic/basic) pH.
Rifampin is active in (acidic/basic) pH.
Flashcards
Ansamycin Antimicrobial
Ansamycin Antimicrobial
Rifampin, also known as Rifampicin, belongs to the Ansamycins family.
WHO Ranking of Ansamycins
WHO Ranking of Ansamycins
Ansamycins are ranked as critically important antimicrobials by the World Health Organization (WHO).
Rifampin Solubility
Rifampin Solubility
Rifampin is highly liposoluble, enabling it to easily penetrate cell membranes.
Rifampin pH Stability
Rifampin pH Stability
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Rifampin Dosage Adjustment
Rifampin Dosage Adjustment
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Rifampin Distribution and Binding
Rifampin Distribution and Binding
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Rifampin Metabolism
Rifampin Metabolism
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