16 Questions
What is the principle exploited by body plethysmography?
Detection of changes in box pressure
Which parameter is not measured in the Penh system for unrestrained animals?
Inspiratory time (Ti)
What is the major difference between head-out plethysmography in conscious rodents and whole-body plethysmography?
Capture of true respiratory flow
What does the Penh system for unrestrained animals screen for?
Pulmonary airway reactivity
How are animals prepared for head-out plethysmography in conscious rodents?
They are trained for 5 days in increasing time periods
Which law is exploited by body plethysmography?
Boyle's law
What is the purpose of the head chamber in the body plethysmograph?
To supply an opening for spraying the tested drug
Which parameter is used to quantify an elongation of the period from the end of the expiration until the start of the new inspiration?
Time of brake (TB)
Why is orotracheal intubation used in spontaneously breathing, anesthetized animals?
To calculate lung resistance (RL)
What is the advantage of non-invasive spirometry over invasive spirometry?
The breathing pattern is nearly natural
What is the disadvantage of invasive spirometry compared to non-invasive spirometry?
Less sensitive and less specific
What is measured by a pneumotachograph connected to the body chamber?
Flow rate and volume
Which parameter can be calculated by processing tidal respiratory flow and transpulmonary pressure?
Lung resistance (RL)
What is the purpose of the neck collar in the body plethysmograph?
To protrude the head of each animal
Which parameter quantifies an elongation of the period from the end of the inspiration until the start of the expiration?
Time of brake (TB)
Which part of the apparatus is supplied with an opening through which the tested drug is sprayed?
Head Chamber
Test your knowledge on the non-invasive techniques used for evaluating respiratory system functions in animals. Learn about the Penh system and its applications in screening pulmonary airway reactivity and diagnosing obstructive lung disease.
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