Podcast
Questions and Answers
Which of the following is NOT a primary function of the cytoskeleton?
Which of the following is NOT a primary function of the cytoskeleton?
- Maintaining cell shape
- Generating energy for the cell (correct)
- Providing cellular motility
- Positioning organelles within cells
What distinguishes the cytoskeleton from the body's skeletal system?
What distinguishes the cytoskeleton from the body's skeletal system?
- The cytoskeleton is more stable and rigid
- The cytoskeleton does not provide stability
- The cytoskeleton rapidly disassembles and reassembles (correct)
- The cytoskeleton is less dynamic
A cell requires the ability to resist compression. Which cytoskeletal element would be MOST suited to provide this function?
A cell requires the ability to resist compression. Which cytoskeletal element would be MOST suited to provide this function?
- Intermediate filaments
- Microfilaments
- Microtubules (correct)
- Actin filaments
Which of the following cellular structures is directly involved in the movement of organelles within a cell?
Which of the following cellular structures is directly involved in the movement of organelles within a cell?
How do motor proteins facilitate the movement of organelles along microtubules?
How do motor proteins facilitate the movement of organelles along microtubules?
What is the primary function of the cortical network formed by microfilaments beneath the plasma membrane?
What is the primary function of the cortical network formed by microfilaments beneath the plasma membrane?
Which type of cytoskeletal element is MOST involved in muscle contraction?
Which type of cytoskeletal element is MOST involved in muscle contraction?
Which of the following is an example of a function primarily carried out by actin filaments?
Which of the following is an example of a function primarily carried out by actin filaments?
What characteristic differentiates intermediate filaments from microtubules and microfilaments?
What characteristic differentiates intermediate filaments from microtubules and microfilaments?
Which of the following proteins is a primary component of intermediate filaments?
Which of the following proteins is a primary component of intermediate filaments?
What is the MOST likely function of intermediate filaments containing lamins?
What is the MOST likely function of intermediate filaments containing lamins?
What type of cell junction forms a continuous seal, preventing the movement of fluid across cell layers?
What type of cell junction forms a continuous seal, preventing the movement of fluid across cell layers?
What is the primary function of desmosomes in tissues like muscle?
What is the primary function of desmosomes in tissues like muscle?
Which type of cell junction allows for rapid cell-to-cell communication through the passage of ions and small molecules?
Which type of cell junction allows for rapid cell-to-cell communication through the passage of ions and small molecules?
In which of the following scenarios would gap junctions be MOST beneficial?
In which of the following scenarios would gap junctions be MOST beneficial?
What is the main role of the extracellular matrix (ECM) in tissues?
What is the main role of the extracellular matrix (ECM) in tissues?
How does the composition of the extracellular matrix (ECM) typically vary?
How does the composition of the extracellular matrix (ECM) typically vary?
What is the process by which cells secrete the components of the extracellular matrix (ECM)?
What is the process by which cells secrete the components of the extracellular matrix (ECM)?
What is the MOST abundant glycoprotein found in the extracellular matrix (ECM)?
What is the MOST abundant glycoprotein found in the extracellular matrix (ECM)?
Water is trapped within the ECM, resisting compression and helping retain tissue shape. This function relies primarily on ______.
Water is trapped within the ECM, resisting compression and helping retain tissue shape. This function relies primarily on ______.
Fibronectins and integrins mediate which key interaction?
Fibronectins and integrins mediate which key interaction?
Which of the following statements accurately describes the dynamic nature of the cytoskeleton?
Which of the following statements accurately describes the dynamic nature of the cytoskeleton?
A researcher is studying a cell that needs to withstand significant stretching forces. Which type of cell junction is MOST likely to be abundant in this cell?
A researcher is studying a cell that needs to withstand significant stretching forces. Which type of cell junction is MOST likely to be abundant in this cell?
If a cell is unable to properly secrete collagen, what function would be MOST directly affected?
If a cell is unable to properly secrete collagen, what function would be MOST directly affected?
Consider a drug that inhibits the function of motor proteins associated with microtubules. What cellular process would be MOST directly affected?
Consider a drug that inhibits the function of motor proteins associated with microtubules. What cellular process would be MOST directly affected?
Cardiac muscle cells require coordinated and rapid communication to contract efficiently. Which type of cell junction is MOST likely to facilitate this function?
Cardiac muscle cells require coordinated and rapid communication to contract efficiently. Which type of cell junction is MOST likely to facilitate this function?
A mutation disrupts the ability of cells to produce keratin. Which tissue would be MOST affected by this mutation?
A mutation disrupts the ability of cells to produce keratin. Which tissue would be MOST affected by this mutation?
Which of the following events would MOST likely occur if tight junctions in the epithelial cells lining the small intestine were compromised?
Which of the following events would MOST likely occur if tight junctions in the epithelial cells lining the small intestine were compromised?
After death, cells break down, but intermediate filaments can persist. What is an example of a structure composed of intermediate filaments that remains after cellular degradation?
After death, cells break down, but intermediate filaments can persist. What is an example of a structure composed of intermediate filaments that remains after cellular degradation?
Which of the following BEST describes the roles of both fibronectin and integrin?
Which of the following BEST describes the roles of both fibronectin and integrin?
A researcher discovers a new cell type that lacks microtubules. What function would this cell MOST likely be unable to perform?
A researcher discovers a new cell type that lacks microtubules. What function would this cell MOST likely be unable to perform?
If a tissue sample shows a significant decrease in proteoglycans, which characteristic of the extracellular matrix (ECM) would be MOST directly affected?
If a tissue sample shows a significant decrease in proteoglycans, which characteristic of the extracellular matrix (ECM) would be MOST directly affected?
A researcher treats cells with a compound that prevents actin subunits from polymerizing into microfilaments. Which cellular process would be MOST affected?
A researcher treats cells with a compound that prevents actin subunits from polymerizing into microfilaments. Which cellular process would be MOST affected?
In a cell undergoing mechanical stress, which type of junction would be MOST important for providing structural integrity and preventing tissue tearing?
In a cell undergoing mechanical stress, which type of junction would be MOST important for providing structural integrity and preventing tissue tearing?
Which property of microtubules directly contributes to their role in maintaining cell shape and resisting compression?
Which property of microtubules directly contributes to their role in maintaining cell shape and resisting compression?
In some disease states, neurofilaments can malfunction. Where would these problems MOST likely manifest?
In some disease states, neurofilaments can malfunction. Where would these problems MOST likely manifest?
Hyaluronic acid is included in some beauty products to retain moisture to 'plump' skin. Where is hyaluronic acid primarily found, and how does it retain the moisture?
Hyaluronic acid is included in some beauty products to retain moisture to 'plump' skin. Where is hyaluronic acid primarily found, and how does it retain the moisture?
Which type of cytoskeletal filament is involved in cytoplasmic streaming in plants?
Which type of cytoskeletal filament is involved in cytoplasmic streaming in plants?
Which of the following cell junctions is most like 'rivets' in that they provide attachments between sheets of cells?
Which of the following cell junctions is most like 'rivets' in that they provide attachments between sheets of cells?
What is the primary function of cilia on cells in the respiratory tract?
What is the primary function of cilia on cells in the respiratory tract?
Which of the following BEST describes how microtubules facilitate cellular movement?
Which of the following BEST describes how microtubules facilitate cellular movement?
During embryonic development, cells migrate to specific locations to form tissues and organs. Which of the following is MOST crucial for guiding cell migration?
During embryonic development, cells migrate to specific locations to form tissues and organs. Which of the following is MOST crucial for guiding cell migration?
A researcher observes that a particular cell type has an unusually high concentration of desmosomes. What can the researcher infer about the function of this cell type?
A researcher observes that a particular cell type has an unusually high concentration of desmosomes. What can the researcher infer about the function of this cell type?
How do integrins facilitate communication between the extracellular matrix (ECM) and the cytoskeleton?
How do integrins facilitate communication between the extracellular matrix (ECM) and the cytoskeleton?
Many cancer cells can detach from the primary tumor and invade other tissues. Which alteration in cell junctions would MOST directly facilitate this process?
Many cancer cells can detach from the primary tumor and invade other tissues. Which alteration in cell junctions would MOST directly facilitate this process?
Flashcards
Cytoskeleton Function
Cytoskeleton Function
The cytoskeleton helps maintain cell shape and position of organelles. It rapidly disassembles and reassembles to allow cell shape changes.
Microtubules
Microtubules
Microtubules are composed of tubulin subunits and radiate from the centrosome. They resist compression to help maintain cell shape.
Microtubules and Motility
Microtubules and Motility
They provide motility via flagella and cilia. Motor proteins 'walk' organelles along them, transporting cargo.
Microfilaments
Microfilaments
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Actin and Myosin
Actin and Myosin
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Microfilaments in Non-Animals
Microfilaments in Non-Animals
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Intermediate Filaments
Intermediate Filaments
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Intermediate Filaments Function
Intermediate Filaments Function
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Tight Junctions
Tight Junctions
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Desmosomes
Desmosomes
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Gap Junctions
Gap Junctions
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Extracellular Matrix (ECM)
Extracellular Matrix (ECM)
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ECM Components
ECM Components
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ECM Connection Proteins
ECM Connection Proteins
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Study Notes
Lecture 5 Objectives
- Identify the major components of the cytoskeleton: microtubules, microfilaments, and intermediate filaments.
- Explain how these structures regulate cell shape.
- Outline the importance of cell junctions: tight, gap, and desmosomes.
- Describe the composition and origin of the extracellular matrix.
Animal Cell Structures
- Inside the animal cell: the cytoskeleton provides support and mobility.
- Outside the animal cell: the extracellular matrix is made of glycoproteins.
- Animal cells connect via cell junctions.
The Cytoskeleton
- Helps maintain cell shape.
- Helps maintain the position of organelles within cells.
- Rapidly disassembles and reassembles, allowing for rapid changes in cell shape.
- The cytoskeleton is highly dynamic while still providing stability.
Cytoskeleton Composition
- The cytoskeleton is made of three main components: Microtubules, Microfilaments, and Intermediate Filaments.
Microtubules
- Composed of tubulin subunits.
- Radiate out from an organizing center called the centrosome.
- Resist compression, helping maintain cell shape.
- Can also provide cell motility.
- Can provide "snake-like" motion via flagella.
- Can provide "rowing-like" motion via cilia.
- If cells are fixed in place, the beating of cilia moves fluid past them.
- Involved in organelle motility within the cell.
- ATP-powered motor proteins can "walk" organelles along microtubules.
- Allows vesicles, or other organelles, to be transported to specific targets within the cell.
Microfilaments
- Are a double chain of actin subunits.
- Form linear strands.
- Form 3-dimensional networks using branching proteins.
- Resist tension.
- The cortical network under the plasma membrane helps make this region less fluid, maintaining cell shape.
- Interactions between actin and motor proteins such as myosin support cell movement.
- Actin-myosin interactions allow muscle contraction.
- Enable amoeboid movement.
- Enable cytoplasmic streaming in plants.
Intermediate Filaments
- Made of various proteins, including keratins in hair, lamins in the nucleus, and neurofilaments in neurons.
- Supercoiled into “cables”.
- Less dynamic than microtubules or microfilaments.
- Form relatively permanent cellular structures.
- Help maintain cell shape.
- Help anchor organelles.
- May also remain after the cell that made them has died, as in hair and the outer layer of skin.
Cell Junctions
- Three major types of cell junctions: Tight Junctions, Desmosomes, and Gap Junctions.
- Each type differs in structure and function.
Tight Junctions
- Hold neighboring cells tightly pressed together to form a continuous seal.
- Prevent movement of fluid across cell layers.
Desmosomes
- Anchoring junctions, that provide attachments between sheets of cells e.g. muscle.
- Act like rivets (a “torn muscle" could mean a torn desmosome)
- Connected into the cell by intermediate filaments.
Gap Junctions
- A point of cytoplasmic contact between two cells.
- Ions and small molecules can pass from cell to cell.
- Allow for rapid cell-to-cell (intercellular) communication.
Extracellular Matrix (ECM)
- In many tissues, cells do not make direct contact with other cells.
- Cells lie within the ECM, the composition of which varies between tissues.
- The ECM is composed of material secreted by cells.
- Secretion of ECM materials occurs via constitutive exocytosis.
- Most ECM proteins are glycoproteins (protein with added carbohydrates).
- Collagen, a glycoprotein, is the most abundant ECM glycoprotein.
- Collagen fibers have great tensile strength.
- Collagen fibers are embedded in a proteoglycan complex matrix.
- Proteoglycans are proteins with extensive sugar additions.
- Proteoglycans trap water within the ECM.
- Water resists compression and thus helps retain tissue shape.
- The ECM is important in providing strength and resilience to skin.
- Other glycoproteins (fibronectins) attach cells to the ECM.
- Membrane proteins (integrins) connect the ECM to the cytoskeleton.
- Integrins provide a communication link from ECM to the cell interior.
Lecture 5 Summary
- The cytoskeleton is dynamic, provides structure and stability, and has three main components.
- Microtubules, microfilaments, and intermediate filaments have distinct structures and therefore functions within the cell.
- Tight junctions, desmosomes, and gap junctions are important for adhesion and communication between cells.
- The extracellular matrix (ECM) is the non-cellular part of tissues secreted via constitutive exocytosis.
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