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Questions and Answers
Which of the following is NOT a major role of the nervous system?
Which of the following is NOT a major role of the nervous system?
Which of these statements BEST describes the difference between a neuron and a nerve?
Which of these statements BEST describes the difference between a neuron and a nerve?
What is the primary function of a synapse?
What is the primary function of a synapse?
Which of the following is NOT an effector cell?
Which of the following is NOT an effector cell?
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Which statement BEST describes the role of the endocrine system in coordination with the nervous system?
Which statement BEST describes the role of the endocrine system in coordination with the nervous system?
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What is the primary difference between a neuron and a regular cell regarding their electrical properties?
What is the primary difference between a neuron and a regular cell regarding their electrical properties?
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What is the typical range for the size of a membrane potential (MP) in living cells?
What is the typical range for the size of a membrane potential (MP) in living cells?
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What is the definition of current in the context of electricity?
What is the definition of current in the context of electricity?
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What is the primary reason for the resting membrane potential of a cell?
What is the primary reason for the resting membrane potential of a cell?
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Which of the following are considered principle ions involved in the resting membrane potential?
Which of the following are considered principle ions involved in the resting membrane potential?
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Which of the following is NOT a type of membrane potential found in excitable cells?
Which of the following is NOT a type of membrane potential found in excitable cells?
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What is the typical resting membrane potential of a neuron axon?
What is the typical resting membrane potential of a neuron axon?
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What is the most accurate description of membrane potential?
What is the most accurate description of membrane potential?
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What is the main factor responsible for generating the additional -55 mV potential in neurons?
What is the main factor responsible for generating the additional -55 mV potential in neurons?
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Which of the following statements is TRUE regarding the sodium-potassium pump?
Which of the following statements is TRUE regarding the sodium-potassium pump?
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The resting potential of neurons (-70 mV) is a result of the combined contributions of which three factors?
The resting potential of neurons (-70 mV) is a result of the combined contributions of which three factors?
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What is the primary function of an action potential in a neuron?
What is the primary function of an action potential in a neuron?
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What is the key difference between graded potentials and action potentials?
What is the key difference between graded potentials and action potentials?
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What is the primary mechanism responsible for maintaining the concentration gradient of potassium ions across the cell membrane?
What is the primary mechanism responsible for maintaining the concentration gradient of potassium ions across the cell membrane?
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Which of the following statements accurately describes depolarization?
Which of the following statements accurately describes depolarization?
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Which of the following is NOT a characteristic of an action potential?
Which of the following is NOT a characteristic of an action potential?
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What is the difference between graded potentials and action potentials?
What is the difference between graded potentials and action potentials?
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What is the significance of the threshold value in the generation of an action potential?
What is the significance of the threshold value in the generation of an action potential?
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What is the role of the sodium-potassium pump in maintaining the resting potential of a neuron?
What is the role of the sodium-potassium pump in maintaining the resting potential of a neuron?
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Which type of ion channel is always open and plays a crucial role in maintaining the resting membrane potential?
Which type of ion channel is always open and plays a crucial role in maintaining the resting membrane potential?
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What makes the sodium-potassium pump an electrogenic pump?
What makes the sodium-potassium pump an electrogenic pump?
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During the falling phase of an action potential:
During the falling phase of an action potential:
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Which of the following scenarios would be most likely to lead to hyperpolarization of a neuron?
Which of the following scenarios would be most likely to lead to hyperpolarization of a neuron?
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How does the refractory period contribute to the propagation of an action potential?
How does the refractory period contribute to the propagation of an action potential?
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What is the primary reason that saltatory conduction allows for fast transmission of action potentials?
What is the primary reason that saltatory conduction allows for fast transmission of action potentials?
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What is the primary difference in action potential conduction between myelinated and unmyelinated axons?
What is the primary difference in action potential conduction between myelinated and unmyelinated axons?
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Which of the following is TRUE regarding the role of the axon hillock in myelinated axons?
Which of the following is TRUE regarding the role of the axon hillock in myelinated axons?
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What is the typical range of conduction velocities for myelinated axons in vertebrates?
What is the typical range of conduction velocities for myelinated axons in vertebrates?
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Why might invertebrates generally have lower conduction velocities compared to vertebrates?
Why might invertebrates generally have lower conduction velocities compared to vertebrates?
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Which of the following is NOT a characteristic of the repolarization phase of the action potential?
Which of the following is NOT a characteristic of the repolarization phase of the action potential?
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What is the primary purpose of the refractory period?
What is the primary purpose of the refractory period?
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How does the concentration of sodium voltage-gated channels at the axon hillock contribute to action potential initiation?
How does the concentration of sodium voltage-gated channels at the axon hillock contribute to action potential initiation?
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What is the role of potassium leak channels in maintaining the resting membrane potential?
What is the role of potassium leak channels in maintaining the resting membrane potential?
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How does the depolarization of one segment of an unmyelinated axon contribute to the initiation of an action potential in the adjacent segment?
How does the depolarization of one segment of an unmyelinated axon contribute to the initiation of an action potential in the adjacent segment?
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How does myelination affect the conduction velocity of an action potential?
How does myelination affect the conduction velocity of an action potential?
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Which of the following is TRUE about the propagation of action potentials in myelinated axons?
Which of the following is TRUE about the propagation of action potentials in myelinated axons?
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What is the role of the sodium-potassium pump in restoring the resting membrane potential after an action potential?
What is the role of the sodium-potassium pump in restoring the resting membrane potential after an action potential?
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Flashcards
Nervous System
Nervous System
A rapid system that coordinates body functions in animals, except sponges.
Neuron
Neuron
An individual cell that transmits information in the nervous system.
Synapse
Synapse
Connection between an axon terminal and an effector cell.
Effector
Effector
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Bioelectricity
Bioelectricity
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Na+/K+ ATPase
Na+/K+ ATPase
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Resting Membrane Potential (RMP)
Resting Membrane Potential (RMP)
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Electrogenic pump
Electrogenic pump
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Graded Potentials
Graded Potentials
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Leak Channels
Leak Channels
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Depolarization
Depolarization
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Hyperpolarization
Hyperpolarization
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Passive Diffusion of K+
Passive Diffusion of K+
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Action Potential (AP) Rise Phase
Action Potential (AP) Rise Phase
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Refractory Period
Refractory Period
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Propagation of Action Potential
Propagation of Action Potential
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AP Conduction in Unmyelinated Axon
AP Conduction in Unmyelinated Axon
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Axon Hillock
Axon Hillock
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Na+/K+ Pump
Na+/K+ Pump
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Electrotonic potentials
Electrotonic potentials
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Action potentials
Action potentials
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Threshold value
Threshold value
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Voltage-gated channels
Voltage-gated channels
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Falling phase of AP
Falling phase of AP
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Ion currents
Ion currents
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Axon Diameter
Axon Diameter
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Saltatory Conduction
Saltatory Conduction
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Myelin Sheath
Myelin Sheath
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Node of Ranvier
Node of Ranvier
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Action Potential Speed
Action Potential Speed
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Potential
Potential
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Current
Current
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Membrane Potential
Membrane Potential
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Polarized Cells
Polarized Cells
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Excitable Cells
Excitable Cells
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Electrotonic Potentials (EP)
Electrotonic Potentials (EP)
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Action Potentials (AP)
Action Potentials (AP)
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Study Notes
Animal Body Systems - Electrochemical Potentials in Neurons
- Electrochemical potentials in neurons are crucial for communication and function.
- All living cells are electrically polarized, meaning they have a membrane potential (MP).
- The inside of the membrane is negative relative to the outside.
- The size of the MP ranges from -10 to -90 mV.
- Neurons and muscle cells are excitable cells, having large membrane potentials and specialized mechanisms to regulate.
- Three significant types of membrane potentials include resting membrane potential, electrotonic potentials, and action potentials.
- Membrane potentials and currents are reliant on inorganic ions.
- All cells possess resting membrane potential, measured when inactive.
- Unequal distribution of positive and negative charges across the membrane creates a potential difference (resting potential).
- Key ions involved are sodium (Na⁺) and potassium (K⁺).
Ion Concentrations in Cells
- Extracellular fluid generally has high sodium (Na⁺) and low potassium (K⁺) concentrations.
- Intracellular fluid usually has high potassium (K⁺) and low sodium (Na⁺) concentrations.
- Specific concentrations, in millimoles (mM) vary:
- Intracellular Na⁺: ~15 mM
- Extracellular Na⁺: ~150 mM
- Intracellular K⁺: ~150 mM
- Extracellular K⁺: ~5 mM
Ion Gradients in Cells
- Ion gradients are maintained by active transport using the Na⁺/K⁺ ATPase pump.
- This pump moves 3 sodium ions out of the cell and 2 potassium ions into the cell.
- The pump is electrogenic, meaning it generates a small electrical potential.
- A -10 mV potential is generated from ion gradients.
- Anionic proteins, within the cell, contribute to a -5 mV potential.
The Additional Potential in Neurons
- The resting potential of neurons (-55 mV) arises primarily from passive diffusion of K+ through open K+ channels.
- There's a chemical gradient for K+, but no electrical gradient.
- Na+/K+ ATPase and leak channels together create an electrochemical gradient.
Resting Potential of Neurons
- Na+/K+ active transport pumps establish concentration gradients of Na+ and K+ across the membrane.
- Open channels (leak channels) allow K+ ions to flow freely outward.
- Negatively charged molecules (proteins) inside cannot cross the membrane.
- Results in a resting membrane potential of -70 mV.
Membrane Ion Channels
- Channels are specific to each ion.
- Leak channels are always open, e.g., K⁺ channel at rest.
- Other channels are regulated (gated).
- Voltage-gated channels are common in neurons.
- Ion movement depends on the concentration gradient.
Graded Potentials
- Changes in membrane potential due to ion permeability are graded potentials.
- Electrotonic potentials are a type of graded potential common in dendrites and cell bodies.
Electrotonic Potentials
- Current (ions) travels along the membrane surface, generating a small (mV) potential change.
- Can depolarize or hyperpolarize.
- Short distance travel.
- Critical for initiating action potentials in the axon hillock.
Action Potentials
- Action potentials are rapid and large changes in membrane potential.
- Transient and have an all-or-nothing characteristic.
- Depolarizes the membrane (from -70 to +35 mV).
- Initiated at the axon hillock and travel along the entire axon.
- Rely on ion currents through voltage-gated ion channels.
Generation of an Action Potential
- Triggered when a stimulus pushes the resting potential to threshold.
- Voltage-gated Na⁺ and K⁺ channels open and close in response to voltage changes.
- Inward flow of Na⁺ changes the membrane potential to positive, and outward flow of K⁺ returns it to negative values.
Depolarization
- Action potentials depend on voltage-gated ion channels (Na⁺ and K⁺).
- Na⁺, voltage-gated sodium channels open, causing rapid Na⁺ influx.
- K⁺, voltage-gated potassium channels open, causing K⁺ efflux.
The Rest of the Action Potential (Falling Phase)
- K⁺ channels open more, leading to K⁺ efflux and repolarization (return to negative potential).
- Na⁺ channels become inactivated; K⁺ channels close eventually.
Propagation of Action Potentials
- Action potentials move along axons as depolarization occurs in successive segments.
AP Propagation Along Axon
- Initiated at the axon hillock.
- Movements are unchanged along the axon membrane towards terminals.
- Dendrites and cell bodies have a concentration of K⁺ channels that reduce backward propagation.
AP Conduction in Unmyelinated Axons
- Threshold reduction occurs at the axon hillock.
- Na⁺ concentration influences channel locations.
- Currents spread along the membrane to create new action potentials.
AP Conduction in Myelinated Axons - Saltatory Conduction
- Myelin prevents ions from crossing the membrane (reduced current loss).
- Na⁺ and K⁺ concentrations are high at nodes.
- Currents leap between nodes resulting in faster conduction.
The Hodgkin-Huxley Cycle
- The rise phase of the action potential is positive feedback.
- Further depolarization → opening of Na⁺ channels → increased Na⁺ flow → further depolarization.
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Description
Explore the fascinating world of electrochemical potentials in neurons, a crucial aspect for understanding their communication and function. This quiz covers topics like resting membrane potential, action potentials, and the roles of sodium and potassium ions. Test your knowledge on the fundamental principles governing neuronal activity!