15 Questions
What is the main cause of microcytic hypochromic anemia?
Deficiency in iron
Which symptom is NOT associated with iron deficiency anemia?
Sore or inflamed, swollen tongue
What is indicative of megaloblastic anemia?
Enlarged cells and nuclei
Who is more commonly affected by iron insufficiency anemia?
Women
What is the primary difference between the normal erythrocytes and those deficient in iron and hemoglobin?
Microcytic and hypochromic characteristics
What is the main function of ferritin in iron storage?
To oxidize iron to Fe3+ and store it in a mineral form
Which organelle is involved in the release of iron from ferritin?
Lysosomes
What happens to partially denatured ferritin when iron stores are high?
It is called hemosiderin
What is the normal range for blood ferritin in women?
11 to 307 micrograms per liter
What is the basic iron storage unit in ferritin?
(FeO(OH)) with some FeO(H2PO4)
What is the main function of hepcidin in the body?
To inhibit the iron exporter ferroportin in various body tissues
What effect does increased hepcidin levels have on iron supply during some infections and cancers?
It restricts iron supply, thereby limiting bacterial growth
How does hepcidin affect iron absorption from the diet?
It decreases dietary iron absorption by blocking ferroportin
What regulates hepcidin at the transcriptional level?
High levels of intracellular iron
In which cells does hepcidin block the iron exporter ferroportin?
Intestinal enterocytes and macrophages
This quiz covers the different types of anemia, including iron-deficient anemia and megaloblastic anemia. It also discusses the causes and characteristics of each type of anemia, such as pale erythrocytes and megaloblastic cells in bone marrow.
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