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Anemia: Types and Causes

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Questions and Answers

What is the main cause of microcytic hypochromic anemia?

Pregnancy

Deficiency in iron (correct)

Chronic blood loss

Massive hemorrhage

Which symptom is NOT associated with iron deficiency anemia?

Cold hands and feet

Headache, lightheadedness, dizziness

Sore or inflamed, swollen tongue (correct)

Restless leg syndrome

What is indicative of megaloblastic anemia?

Iron deficiency

Normal bone marrow

Failure to make sufficient number of normal erythrocytes

Enlarged cells and nuclei (correct)

Who is more commonly affected by iron insufficiency anemia?

Women Signup and view all the answers

What is the primary difference between the normal erythrocytes and those deficient in iron and hemoglobin?

Microcytic and hypochromic characteristics Signup and view all the answers

What is the main function of ferritin in iron storage?

To oxidize iron to Fe3+ and store it in a mineral form Signup and view all the answers

Which organelle is involved in the release of iron from ferritin?

Lysosomes Signup and view all the answers

What happens to partially denatured ferritin when iron stores are high?

It is called hemosiderin Signup and view all the answers

What is the normal range for blood ferritin in women?

11 to 307 micrograms per liter Signup and view all the answers

What is the basic iron storage unit in ferritin?

(FeO(OH)) with some FeO(H2PO4) Signup and view all the answers

What is the main function of hepcidin in the body?

To inhibit the iron exporter ferroportin in various body tissues Signup and view all the answers

What effect does increased hepcidin levels have on iron supply during some infections and cancers?

It restricts iron supply, thereby limiting bacterial growth Signup and view all the answers

How does hepcidin affect iron absorption from the diet?

It decreases dietary iron absorption by blocking ferroportin Signup and view all the answers

What regulates hepcidin at the transcriptional level?

High levels of intracellular iron Signup and view all the answers

In which cells does hepcidin block the iron exporter ferroportin?

Intestinal enterocytes and macrophages Signup and view all the answers