72 Questions
What is the primary purpose of a reticulocyte count?
To check if the bone marrow is producing the right amount of red blood cells
Which of the following conditions is characterized by a positive Coombs test?
Autoimmune hemolytic anemia
What is the significance of a low serum ferritin level?
It confirms iron deficiency
Which of the following is a characteristic of iron deficiency anemia?
Microcytic anemia
What is the significance of a high LDH level in the blood?
It indicates hemolysis or tissue damage
Which of the following is a common cause of anemia in women of childbearing age?
Iron deficiency
What is the purpose of a comprehensive chemistry profile in the evaluation of anemia?
To identify underlying causes of anemia
Which of the following is a characteristic of autoimmune hemolytic anemia?
Shortened red blood cell survival
What is the significance of a low haptoglobin level?
It indicates hemolysis
Which of the following is a common finding in patients with hypothyroidism?
Decreased production of red blood cells
What is the initial approach to treating iron deficiency anemia?
Oral iron therapy every other day
What is the primary goal when switching from oral to IV iron therapy in iron deficiency anemia?
To make up for the lost amount of iron
Which of the following is a component of healthy clotting?
Von Willebrand Factor
What is the term for the formation of a clot in an unbroken vessel?
Thrombus
What is the laboratory test that can indicate the presence of a clot somewhere in the body?
D-Dimer
Which of the following disorders can predispose to bleeding?
Iron deficiency anemia
What is the term for the condition of having elevated platelet levels?
Thrombocytosis
What is the characteristic of Polycythemia Vera that leads to hyperviscosity?
Increased total blood contents
Which of the following is a cause of hypercoagulability?
All of the above
What is the term for the laboratory test that assesses platelet function?
PFA
What is the primary function of hemoglobin inside red blood cells?
To carry oxygen from the lungs to tissues and organs
Which of the following is NOT a risk factor for anemia?
Having a healthy immune system
What is the approximate proportion of the world's population affected by anemia?
30%
What is the primary site of blood production in adults?
The bone marrow
What is the most common type of white blood cell?
Neutrophil
Which of the following is a consequence of anemia?
Decreased ability to remove CO2 from tissues
What is the primary diagnostic test for iron overload?
Liver biopsy
What is the hepatic iron index used to diagnose?
Homozygous hemochromatosis
Which of the following bacteria is not associated with infections in patients with hemochromatosis?
Staphylococcus aureus
What is the estimated percentage of affected males that develop cirrhosis?
10%
What is the characteristic radiologic finding in the MCP joints of patients with hemochromatosis?
Hook-like osteophytes
What is the treatment for dilated cardiomyopathy in patients with hemochromatosis?
Phlebotomy
What is the most common endocrine abnormality in patients with hemochromatosis?
Hypogonadism
What is the goal of phlebotomy treatment in patients with hemochromatosis?
Maintain ferritin levels at 3
What is the recommended dose of morphine for pain management in patients with hemochromatosis?
5-10mg IV
What is the purpose of transfusion in patients with hemochromatosis?
Increase oxygenation
What is the percentage of RBCs in the blood that Hematocrit (Hct) measures?
The percentage of RBCs in your blood
What is the term for the measurement of the Red Blood Cell Volume?
Mean Corpuscular Volume
What is the difference between a decrease in RDW and a normal RDW?
A decrease in RDW indicates very little variation in size of RBC, while a normal RDW indicates variation in size of RBC
What is the MCV range for microcytic anemia?
MCV < 100
What is the additional category of macrocytic anemia besides MCV > 110?
Megaloblastic
What is the cause of megaloblastic anemia due to cells sticking together and being read as one by the machine?
Spurious Megaloblastic anemia
What is the treatment for B12 deficiency in patients with intrinsic factor deficiency?
IM injection of B12 for life
What is the test used to differentiate between B12 and folate deficiencies?
Methylmalonic acid (MMA) levels and homocysteine levels
What is the diagnostic value of ferritin levels?
A proxy for storage of iron in the body
What is the significance of transferrin saturation levels less than 20%?
Iron deficiency
What is the primary goal of therapeutic phlebotomy in the treatment of Polycythemia Vera?
Achieving hemoglobin levels within normal range
Which of the following is NOT a major criterion for the diagnosis of Polycythemia Vera?
Serum EPO level below normal
What is the underlying mechanism of Factor V Leiden mutation that leads to hypercoagulability?
Resistance of Factor V to inactivation by Protein C
Which of the following is a common inherited cause of hypercoagulability that results from a single point mutation?
Factor V Leiden mutation
What is the effect of sleep apnea on hematopoiesis?
Increased production of red blood cells
What is the purpose of daily aspirin in the treatment of Polycythemia Vera?
Reducing platelet activity
What is the risk of first VTE for compound heterozygotes with FVL and G20210A?
20
What is the function of Protein C in the coagulation cascade?
Inactivate Factor V and Factor VIII
What is the most common type of Protein C deficiency?
Type 1: reduced protein C
What is the purpose of the Wells Score in diagnosing DVT?
To determine the probability of DVT
What is the treatment for acute proximal DVT?
Three months of continuous anticoagulation
What is the purpose of the PERC rule in diagnosing PE?
To determine the probability of PE in low-risk patients
What is the testing of choice for diagnosing PE?
CTA with PE protocol
What is the definition of a massive PE?
Hemodynamic instability, generally hypotension/shock
What is the purpose of obtaining troponin values in patients with PE?
To categorize PE into low-risk, submassive, or massive
What is the significance of a superficial thrombosis in the context of DVT?
Treatment depends on multiple factors and is not always required
What is a recommended treatment duration for low-risk Pulmonary Embolism?
3-6 months
When is it recommended to consider testing for thrombophilias?
Only when it will change the treatment plan
What is the primary function of IVC Filters?
To catch a clot trying to travel to the lungs from the lower extremities
What is the typical treatment duration for an unprovoked Pulmonary Embolism?
Long-term anticoagulation
What is the name of the condition caused by antibodies that form to heparin-platelet complex?
Heparin-Induced Thrombocytopenia
What is the recommended method of prophylaxis in patients with a high risk of VTE?
Pharmacologic and mechanical prophylaxis
What is the diagnosis of VITT based on?
All 5 criteria: COVID vaccine, thrombosis, thrombocytopenia, PF4-ELISA, and imaging
What is the recommended treatment for confirmed VITT?
Initiate therapy with non-heparin anticoagulation
What is the name of the disorder characterized by decreased platelets and bleeding?
Thrombocytopenia
What is a condition that can raise ferritin levels?
All of the above
Test your knowledge of anemia, a condition characterized by a decrease in red blood cells or hemoglobin, leading to insufficient oxygen delivery to tissues. This quiz covers the general causes, symptoms, and epidemiology of anemia, including bleeding, underproduction, and increased needs. Assess your understanding of this prevalent health issue affecting 30% of the world's population.
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