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Anemia Mechanisms Quiz

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Questions and Answers

What is the primary pathophysiologic mechanism for the anemia in this patient?

Microvascular thrombi

Cytoskeleton abnormalities

Mechanical trauma to RBCs (correct)

Impaired DNA synthesis

Which of the following RBC morphological changes is NOT typically seen in this patient's peripheral smear?

Oval-macrocytes (correct)

Helmet cells

Red blood cell fragments

Burr cells

What is the mechanism by which a prosthetic heart valve can cause hemolysis?

Microvascular thrombi formation

Cytoskeleton abnormalities in red blood cells

Excessive shear and turbulence in the cardiac circulation (correct)

Impaired DNA synthesis in red blood cells

What is the characteristic RBC morphology associated with cytoskeleton abnormalities?

Spherocytes, elliptocytes, or stomatocytes Signup and view all the answers

What is the characteristic RBC morphology associated with megaloblastic anemia?

Oval-macrocytes Signup and view all the answers

What is the association between burr cells and microangiopathic hemolytic anemia?

Burr cells can occur as an artifact or in association with microangiopathic hemolytic anemia Signup and view all the answers

Why is the normal platelet count in this patient important in ruling out microangiopathic hemolytic anemia?

Thrombocytopenia is the pathophysiologic mechanism for microangiopathic hemolytic anemia Signup and view all the answers

What is the characteristic peripheral blood finding associated with megaloblastic anemia, in addition to oval-macrocytes?

Hypersegmented neutrophils Signup and view all the answers

Why are the RBC fragments, burr cells, and helmet cells seen in this patient's peripheral smear?

They are consistent with mechanical trauma to the red blood cells Signup and view all the answers

What is the most likely cause of the patient's anemia, based on the information provided?

Mechanical hemolysis from a prosthetic heart valve Signup and view all the answers