Podcast
Questions and Answers
What is the primary pathophysiologic mechanism for the anemia in this patient?
What is the primary pathophysiologic mechanism for the anemia in this patient?
- Microvascular thrombi
- Cytoskeleton abnormalities
- Mechanical trauma to RBCs (correct)
- Impaired DNA synthesis
Which of the following RBC morphological changes is NOT typically seen in this patient's peripheral smear?
Which of the following RBC morphological changes is NOT typically seen in this patient's peripheral smear?
- Oval-macrocytes (correct)
- Helmet cells
- Red blood cell fragments
- Burr cells
What is the mechanism by which a prosthetic heart valve can cause hemolysis?
What is the mechanism by which a prosthetic heart valve can cause hemolysis?
- Microvascular thrombi formation
- Cytoskeleton abnormalities in red blood cells
- Excessive shear and turbulence in the cardiac circulation (correct)
- Impaired DNA synthesis in red blood cells
What is the characteristic RBC morphology associated with cytoskeleton abnormalities?
What is the characteristic RBC morphology associated with cytoskeleton abnormalities?
What is the characteristic RBC morphology associated with megaloblastic anemia?
What is the characteristic RBC morphology associated with megaloblastic anemia?
What is the association between burr cells and microangiopathic hemolytic anemia?
What is the association between burr cells and microangiopathic hemolytic anemia?
Why is the normal platelet count in this patient important in ruling out microangiopathic hemolytic anemia?
Why is the normal platelet count in this patient important in ruling out microangiopathic hemolytic anemia?
What is the characteristic peripheral blood finding associated with megaloblastic anemia, in addition to oval-macrocytes?
What is the characteristic peripheral blood finding associated with megaloblastic anemia, in addition to oval-macrocytes?
Why are the RBC fragments, burr cells, and helmet cells seen in this patient's peripheral smear?
Why are the RBC fragments, burr cells, and helmet cells seen in this patient's peripheral smear?
What is the most likely cause of the patient's anemia, based on the information provided?
What is the most likely cause of the patient's anemia, based on the information provided?
