Anemia Mechanisms Quiz
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Anemia Mechanisms Quiz

Test your knowledge of anemia mechanisms by identifying key features in patient history and peripheral smear. Learn about the connection between red blood cell fragments, burr cells, and helmet cells with traumatic hemolysis from conditions like microangiopathic hemolytic anemia or mechanical damage.

Created by
@FineLookingSerpent

Questions and Answers

What is the primary pathophysiologic mechanism for the anemia in this patient?

Mechanical trauma to RBCs

Which of the following RBC morphological changes is NOT typically seen in this patient's peripheral smear?

Oval-macrocytes

What is the mechanism by which a prosthetic heart valve can cause hemolysis?

Excessive shear and turbulence in the cardiac circulation

What is the characteristic RBC morphology associated with cytoskeleton abnormalities?

<p>Spherocytes, elliptocytes, or stomatocytes</p> Signup and view all the answers

What is the characteristic RBC morphology associated with megaloblastic anemia?

<p>Oval-macrocytes</p> Signup and view all the answers

What is the association between burr cells and microangiopathic hemolytic anemia?

<p>Burr cells can occur as an artifact or in association with microangiopathic hemolytic anemia</p> Signup and view all the answers

Why is the normal platelet count in this patient important in ruling out microangiopathic hemolytic anemia?

<p>Thrombocytopenia is the pathophysiologic mechanism for microangiopathic hemolytic anemia</p> Signup and view all the answers

What is the characteristic peripheral blood finding associated with megaloblastic anemia, in addition to oval-macrocytes?

<p>Hypersegmented neutrophils</p> Signup and view all the answers

Why are the RBC fragments, burr cells, and helmet cells seen in this patient's peripheral smear?

<p>They are consistent with mechanical trauma to the red blood cells</p> Signup and view all the answers

What is the most likely cause of the patient's anemia, based on the information provided?

<p>Mechanical hemolysis from a prosthetic heart valve</p> Signup and view all the answers

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