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Anemia and Hemoglobinopathies Quiz

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Questions and Answers

What is the specific cause of sickle cell anemia?

Thalassemia mutation

Globin chain deletion (correct)

Gene expression deletion

Haptoglobin deficiency

Which test is used to differentiate between Hemoglobin S and Hemoglobin C in electrophoresis?

Hemoglobin electrophoresis migration pattern (correct)

Dithionite solubility test

Prussian Blue stain

New Methylene Blue stain

What is the primary cause of Thalassemia?

Globin chain deletion (correct)

Hemoglobin C crystals

Lead poisoning

Globin chain substitution

Which laboratory test indicates intravascular hemolysis?

Dithionite solubility test Signup and view all the answers

In hemolytic anemias, what is the primary characteristic of extravascular hemolysis?

Increased Haptoglobin levels Signup and view all the answers

What distinguishes autoimmune hemolytic anemia from hemolytic anemias due to other causes?

Elevated Retic counts Signup and view all the answers

What are the three main causes of megaloblastic anemia?

Iron deficiency, folic acid deficiency, vitamin B12 deficiency Signup and view all the answers

What is the most common cause of nonmegaloblastic anemia?

Iron deficiency Signup and view all the answers

Define anemia and describe the clinical features.

Anemia is a deficiency of red blood cells; it presents with weakness, fatigue, and pale skin. Signup and view all the answers

Differentiate between iron deficiency anemia, sideroblastic anemia, and anemia of chronic disease based on laboratory findings.

Iron deficiency anemia has low iron, sideroblastic anemia has normal iron, and anemia of chronic disease has high iron. Signup and view all the answers

Explain the importance of distinguishing between vitamin B12 and folic acid deficiencies.

Misdiagnosis can lead to inappropriate treatment and potentially worsen the condition. Signup and view all the answers

What are the expected findings on the peripheral blood smear that differentiate between folic acid and vitamin B12 deficiencies?

Folic acid deficiency shows hypersegmented neutrophils while vitamin B12 deficiency shows oval macrocytes. Signup and view all the answers