Anemia and Hemoglobinopathies Quiz
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Questions and Answers

What is the specific cause of sickle cell anemia?

  • Thalassemia mutation
  • Globin chain deletion (correct)
  • Gene expression deletion
  • Haptoglobin deficiency
  • Which test is used to differentiate between Hemoglobin S and Hemoglobin C in electrophoresis?

  • Hemoglobin electrophoresis migration pattern (correct)
  • Dithionite solubility test
  • Prussian Blue stain
  • New Methylene Blue stain
  • What is the primary cause of Thalassemia?

  • Globin chain deletion (correct)
  • Hemoglobin C crystals
  • Lead poisoning
  • Globin chain substitution
  • Which laboratory test indicates intravascular hemolysis?

    <p>Dithionite solubility test (B)</p> Signup and view all the answers

    In hemolytic anemias, what is the primary characteristic of extravascular hemolysis?

    <p>Increased Haptoglobin levels (C)</p> Signup and view all the answers

    What distinguishes autoimmune hemolytic anemia from hemolytic anemias due to other causes?

    <p>Elevated Retic counts (C)</p> Signup and view all the answers

    What are the three main causes of megaloblastic anemia?

    <p>Iron deficiency, folic acid deficiency, vitamin B12 deficiency (B)</p> Signup and view all the answers

    What is the most common cause of nonmegaloblastic anemia?

    <p>Iron deficiency (A)</p> Signup and view all the answers

    Define anemia and describe the clinical features.

    <p>Anemia is a deficiency of red blood cells; it presents with weakness, fatigue, and pale skin. (C)</p> Signup and view all the answers

    Differentiate between iron deficiency anemia, sideroblastic anemia, and anemia of chronic disease based on laboratory findings.

    <p>Iron deficiency anemia has low iron, sideroblastic anemia has normal iron, and anemia of chronic disease has high iron. (A)</p> Signup and view all the answers

    Explain the importance of distinguishing between vitamin B12 and folic acid deficiencies.

    <p>Misdiagnosis can lead to inappropriate treatment and potentially worsen the condition. (A)</p> Signup and view all the answers

    What are the expected findings on the peripheral blood smear that differentiate between folic acid and vitamin B12 deficiencies?

    <p>Folic acid deficiency shows hypersegmented neutrophils while vitamin B12 deficiency shows oval macrocytes. (C)</p> Signup and view all the answers

    Flashcards

    Sickle Cell Anemia Cause

    Globin chain deletion leads to Sickle Cell Anemia

    Hb S vs Hb C Electrophoresis

    Differentiated by migration pattern in electrophoresis

    Thalassemia Cause

    Globin chain deletion is the root cause of Thalassemia.

    Intravascular Hemolysis Test

    Dithionite solubility test indicates intravascular hemolysis.

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    Extravascular Hemolysis

    Increased Haptoglobin levels signify extravascular hemolysis.

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    Autoimmune Hemolytic Anemia

    High reticulocyte counts distinguish it from other hemolytic anemias.

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    Megaloblastic Anemia Causes

    Iron deficiency, folic acid deficiency, and vitamin B12 deficiency cause megaloblastic anemia.

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    Nonmegaloblastic Anemia Cause

    Iron deficiency is the most common cause of non-megaloblastic anemia.

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    Anemia Definition

    A condition characterized by low red blood cell count, causing symptoms like weakness and fatigue.

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    Iron Deficiency Anemia vs Other Anemia (Lab)

    Iron deficiency anemia has low iron, sideroblastic anemia has normal iron, and anemia of chronic disease has high iron levels.

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    B12 vs Folate Deficiency Importance

    Differentiating them is vital for correct treatment and prevents worsening.

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    Folic Acid vs B12 Deficiency (Peripheral Blood)

    Folic acid deficiency shows hypersegmented neutrophils, while B12 deficiency shows oval macrocytes.

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    Peripheral Blood Smear - Folic Acid Deficiency

    Hypersegmented Neutrophils are seen.

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    Peripheral Blood Smear - Vitamin B12 Deficiency

    Oval macrocytes are seen.

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    Peripheral Blood Smear

    A microscopic examination of blood cells to detect abnormalities.

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    Sideroblastic Anemia

    An abnormality of iron metabolism characterized by ringed sideroblasts in the bone marrow.

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    Anemia of Chronic Disease

    Anemia that develops during or as a result of an ongoing illness.

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