12 Questions
What is the specific cause of sickle cell anemia?
Globin chain deletion
Which test is used to differentiate between Hemoglobin S and Hemoglobin C in electrophoresis?
Hemoglobin electrophoresis migration pattern
What is the primary cause of Thalassemia?
Globin chain deletion
Which laboratory test indicates intravascular hemolysis?
Dithionite solubility test
In hemolytic anemias, what is the primary characteristic of extravascular hemolysis?
Increased Haptoglobin levels
What distinguishes autoimmune hemolytic anemia from hemolytic anemias due to other causes?
Elevated Retic counts
What are the three main causes of megaloblastic anemia?
Iron deficiency, folic acid deficiency, vitamin B12 deficiency
What is the most common cause of nonmegaloblastic anemia?
Iron deficiency
Define anemia and describe the clinical features.
Anemia is a deficiency of red blood cells; it presents with weakness, fatigue, and pale skin.
Differentiate between iron deficiency anemia, sideroblastic anemia, and anemia of chronic disease based on laboratory findings.
Iron deficiency anemia has low iron, sideroblastic anemia has normal iron, and anemia of chronic disease has high iron.
Explain the importance of distinguishing between vitamin B12 and folic acid deficiencies.
Misdiagnosis can lead to inappropriate treatment and potentially worsen the condition.
What are the expected findings on the peripheral blood smear that differentiate between folic acid and vitamin B12 deficiencies?
Folic acid deficiency shows hypersegmented neutrophils while vitamin B12 deficiency shows oval macrocytes.
Test your knowledge on anemia, erythropoiesis, classifications of anemia, intrinsic factor, EPO, hemoglobin electrophoresis, thalassemia, megaloblastic changes, Prussian Blue stain, New Methylene Blue stain, and globin chain deletions.
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