Podcast
Questions and Answers
Which of the following techniques is NOT a method for examining the structure of the human body?
Which of the following techniques is NOT a method for examining the structure of the human body?
What is the primary difference between gross anatomy and histology?
What is the primary difference between gross anatomy and histology?
Which of these is NOT a sub-discipline of physiology?
Which of these is NOT a sub-discipline of physiology?
How does comparative physiology contribute to our understanding of human physiology?
How does comparative physiology contribute to our understanding of human physiology?
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What is the main purpose of medical imaging?
What is the main purpose of medical imaging?
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Which of the following is NOT a vestigial structure?
Which of the following is NOT a vestigial structure?
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What genetic similarity between humans and chimpanzees indicates a close evolutionary relationship?
What genetic similarity between humans and chimpanzees indicates a close evolutionary relationship?
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What does the study of evolutionary relationships help us determine?
What does the study of evolutionary relationships help us determine?
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Which of these is NOT a level of human structure from the most complex to simplest?
Which of these is NOT a level of human structure from the most complex to simplest?
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What is the main idea of reductionism in the context of human structure?
What is the main idea of reductionism in the context of human structure?
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Which of the following is an example of anatomical variation in humans?
Which of the following is an example of anatomical variation in humans?
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What is the significance of anatomical variation in humans?
What is the significance of anatomical variation in humans?
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What characteristic distinguishes living organisms from nonliving objects?
What characteristic distinguishes living organisms from nonliving objects?
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Which of the following is a reason why precise spelling is important in anatomy and physiology?
Which of the following is a reason why precise spelling is important in anatomy and physiology?
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Which of the following statements accurately describes the historical evolution of anatomical terminology?
Which of the following statements accurately describes the historical evolution of anatomical terminology?
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What is the primary reason for the use of Latin in anatomical terminology?
What is the primary reason for the use of Latin in anatomical terminology?
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What does "brachium" refer to?
What does "brachium" refer to?
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How is the term "biceps brachii" constructed?
How is the term "biceps brachii" constructed?
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What is the function of combining vowels in scientific terms?
What is the function of combining vowels in scientific terms?
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Which of the following is an example of an acronym used in medical terminology?
Which of the following is an example of an acronym used in medical terminology?
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What is the plural form of "corpus"?
What is the plural form of "corpus"?
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Why is it important to consider physiological variation amongst individuals when treating patients?
Why is it important to consider physiological variation amongst individuals when treating patients?
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Which of the following is NOT a characteristic of life?
Which of the following is NOT a characteristic of life?
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Which of the following is an example of positive feedback in the human body?
Which of the following is an example of positive feedback in the human body?
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What is the primary role of negative feedback in homeostasis?
What is the primary role of negative feedback in homeostasis?
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What is a gradient in the context of human physiology?
What is a gradient in the context of human physiology?
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Which of the following is NOT an example of a gradient in human physiology?
Which of the following is NOT an example of a gradient in human physiology?
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The statement 'Living matter is always compartmentalized into one or more cells' describes which fundamental characteristic of life?
The statement 'Living matter is always compartmentalized into one or more cells' describes which fundamental characteristic of life?
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In the context of physiological variation, why is it important to consider reference values like 'reference man' and 'reference woman'?
In the context of physiological variation, why is it important to consider reference values like 'reference man' and 'reference woman'?
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What is the purpose of a control group in an experiment?
What is the purpose of a control group in an experiment?
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Which of the following best describes a scientific law?
Which of the following best describes a scientific law?
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What is the role of peer review in the scientific process?
What is the role of peer review in the scientific process?
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Which of the following is NOT a characteristic of a scientific theory?
Which of the following is NOT a characteristic of a scientific theory?
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What is the primary purpose of a double-blind study?
What is the primary purpose of a double-blind study?
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Which of the following individuals is credited with the discovery of blood circulation?
Which of the following individuals is credited with the discovery of blood circulation?
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Who made the first detailed observations of bacteria?
Who made the first detailed observations of bacteria?
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Which of the following is NOT a contribution attributed to Aristotle?
Which of the following is NOT a contribution attributed to Aristotle?
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What is the name of the book published by Andreas Vesalius that revolutionized anatomical understanding?
What is the name of the book published by Andreas Vesalius that revolutionized anatomical understanding?
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Which of the following physicians considered disease to have both natural and supernatural causes?
Which of the following physicians considered disease to have both natural and supernatural causes?
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Who wrote the first comprehensive book on microscopy, titled "Micrographia"?
Who wrote the first comprehensive book on microscopy, titled "Micrographia"?
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What was the primary reason why Claudius Galen conducted animal dissections instead of human dissections?
What was the primary reason why Claudius Galen conducted animal dissections instead of human dissections?
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What innovative technique did Andreas Vesalius utilize in his anatomical studies?
What innovative technique did Andreas Vesalius utilize in his anatomical studies?
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Which of the following statements is TRUE about the 'cell theory'?
Which of the following statements is TRUE about the 'cell theory'?
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Which of these individuals was NOT a physician?
Which of these individuals was NOT a physician?
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Flashcards
Sample Size
Sample Size
The number of subjects included in a study.
Control Group
Control Group
A group that resembles the treatment group but does not receive the treatment.
Peer Review
Peer Review
The evaluation of research by experts before publication or funding.
Scientific Fact
Scientific Fact
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Theory
Theory
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Inspection
Inspection
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Histology
Histology
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Gross anatomy
Gross anatomy
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Cytology
Cytology
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Comparative anatomy
Comparative anatomy
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Vestigial structures
Vestigial structures
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Embryological similarities
Embryological similarities
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Molecular markers
Molecular markers
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Chimpanzee and humans
Chimpanzee and humans
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Hierarchy of Complexity
Hierarchy of Complexity
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Reductionism
Reductionism
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Holism
Holism
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Anatomical Variation
Anatomical Variation
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Physiological Variation
Physiological Variation
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Homeostasis
Homeostasis
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Negative Feedback
Negative Feedback
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Example of Negative Feedback
Example of Negative Feedback
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Positive Feedback
Positive Feedback
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Example of Positive Feedback
Example of Positive Feedback
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Gradient in Physiology
Gradient in Physiology
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Forms of Flowing Matter and Energy
Forms of Flowing Matter and Energy
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Importance of Precise Spelling
Importance of Precise Spelling
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Source of Medical Terms
Source of Medical Terms
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Eponyms in Anatomy
Eponyms in Anatomy
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Terminologia Anatomica (TA)
Terminologia Anatomica (TA)
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Medical Terminology Structure
Medical Terminology Structure
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Acronyms in Medicine
Acronyms in Medicine
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Pluralization Rules
Pluralization Rules
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Adjectives in Medical Terms
Adjectives in Medical Terms
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Hippocrates
Hippocrates
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Aristotle
Aristotle
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Claudius Galen
Claudius Galen
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Avicenna
Avicenna
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Andreas Vesalius
Andreas Vesalius
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William Harvey
William Harvey
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Robert Hooke
Robert Hooke
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Antony van Leeuwenhoek
Antony van Leeuwenhoek
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Cell Theory
Cell Theory
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Scientific Method
Scientific Method
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Study Notes
Chapter 1: Major Themes of Anatomy and Physiology
- Anatomy and Physiology (A&P) are about the structure and function of the human body
- A&P is a foundation for advanced studies in healthcare, exercise physiology, pathophysiology, and related fields
- This chapter introduces the history of A&P, human evolution, central physiological concepts, and medical terminology
1.1 The Scope of Anatomy and Physiology
- Expected Learning Outcomes: Define anatomy and physiology, relate them, describe ways to study human anatomy, define subdisciplines of human physiology
Anatomy—The Study of Form
- Methods of Studying Human Anatomy:
- Inspection: Observing the body's structure
- Palpation: Feeling the body's structures
- Auscultation: Listening to body sounds
- Percussion: Tapping on the body to elicit sounds
- Cadaver Dissection: Dissecting human tissues to reveal structure
- Comparative Anatomy: Studying multiple species to understand form, function, and evolution
- Exploratory Surgery: Viewing inside the body to observe without surgery
- Medical Imaging: Using various methods to visualize the internal structures, including Radiography, Histology (microscopic anatomy), Histopathology, Cytology, and Ultrastructure
Anatomy—The Study of Form (Second Part)
- Further Methods of studying anatomy:
- Gross Anatomy: Examining structures with the naked eye
- Histology (Microscopic Anatomy): Examining tissues with a microscope
- Histopathology: Microscopic examination of tissues to identify signs of disease
- Cytology: Studying the structure and function of cells;
- Ultrastructure: Examining cell detail under an electron microscope
Physiology—The Study of Function
- Subdisciplines:
- Neurophysiology: Physiology of the nervous system
- Endocrinology: Physiology of hormones
- Pathophysiology: Mechanisms of disease
- Comparative Physiology: Studying different species to understand body functions, fundamental to our understanding of human physiology, used in drug development
1.2 The Origins of Biomedical Science
- Expected Learning Outcomes: Examples of how modern biomedical science emerged from previous superstitions and authoritarianism, contributions of key people
- Greek and Roman Legacy (Part 1):
- Hippocrates: "Father of medicine," established a code of ethics, urged seeking natural causes of disease.
- Aristotle: Believed diseases could have supernatural or physical causes, early concepts of physician and physiology.
- Complex structures are built from simpler parts
- Greek and Roman Legacy (Part 2):
- Galen: Physician to Roman gladiators, did animal dissections due to cadaver bans, his work was dogma in the middle ages.
The Birth of Modern Medicine (Part 1)
- Maimonides: Jewish physician, wrote influential medical texts, served as physician to the Egyptian sultan Saladin
- Avicenna: (From the Muslim world) "the Galen of Islam", combined Galen and Aristotle's findings with original discoveries, wrote The Canon of Medicine, influential for 500 years
The Birth of Modern Medicine (Part 2)
- Andreas Vesalius: Catholic Church relaxed restrictions on cadaver dissection, performed his own dissections, published De Humani Corporis Fabrica (On the Structure of the Human Body) in 1543
- William Harvey: Early physiologist, experimental physiology, published De Motu Cordis (On the Motion of the Heart) in 1628, described blood flow through the heart
The Birth of Modern Medicine (Part 3)
- Robert Hooke: Made improvements to the compound microscope, first to see and name "cells", Published Micrographia in 1665.
- Antony van Leeuwenhoek: Invented a simple microscope, great magnification, published observations of blood, water, sperm, bacteria (aided by microscope)
The Birth of Modern Medicine (Part 4)
- Matthias Schleiden and Theodor Schwann: Examined many specimens, concluded that all organisms composed of cells, first tenet of cell theory. A major breakthrough in Biomedical history
1.3 Scientific Method (Part 1)
- Expected Learning Outcomes: Describe inductive and hypothetico-deductive methods of obtaining scientific knowledge, describe experimental design for objective and reliable results, explain terms like 'hypothesis', 'fact', 'law', and 'theory'
The Inductive Method
- Described by Francis Bacon
- Making numerous observations; generalizations & predictions
- Knowledge of anatomy obtained by this method
- Proof in science: reliable observations repeatedly confirmed, not falsified by any credible observation.
- All scientific truth is tentative.
The Hypothetico-Deductive Method
- Most physiological knowledge is gained by this method
- Investigator forms a hypothesis
- Formulating an educated speculation or possible solution to the question.
- Good hypotheses are consistent with existing knowledge and testable.
- Falsifiability- If a claim is true, evidence must be available to prove it wrong.
Inductive vs. Deductive reasoning
- Inductive reasoning: Observation, generalizations, predictions, leads to theory
- Deductive reasoning: Theory, predictions, observation, experiment. Uses what's known to predict
Experimental Design
- Sample size: Number of subjects in a study
- Controls: Control group similar to treatment group but does not receive the treatment, to observe effect
- Psychosomatic effects: Effects of subject's state of mind on physiology (placebo effects in a control group)
- Experimenter bias: Avoided through double-blind studies
- Statistical testing: Provides probability statement if treatment is effective.
Peer Review
- Critical evaluation by experts
- Done before funding or publication
- Using verification & repeatability of results
- Guarantees honesty, objectivity, & quality
Facts, laws, and theories
- Scientific Fact: Independently verifiable information.
- Law of Nature: Generalization about how matter/energy behave, resulting from inductive reasoning and repeated observations, typically expressed in verbal statements or mathematical formulas.
- Theory: An explanatory statement or set of statements, derived from facts, laws, and confirmed hypotheses. Summarises knowledge and suggests further studies
1.4 Human Origins and Adaptations (Part 1)
- Expected Learning Outcomes: Explain the relevance of evolution to understanding human form and function, define evolution and natural selection, describe human characteristics from tree-dwelling habits and later evolution, like upright walking.
Human Origins and Adaptations (Part 2)
- Charles Darwin: On the Origin of Species (1859) and Descent of Man (1871)—explained human evolution and relationships with other animals
Evolution, Selection, and Adaptation
- Evolution: Change in genetic composition of populations, driven by natural selection. Example: bacterial resistance to antibiotics.
- Natural Selection: How evolution works; selection pressures promote reproductive success. Example: predators favoring camouflage.
- Adaptations: Inherited characteristics (anatomy and physiology) that enable organisms to succeed. Example: better camouflage from predators
Evidence for Evolution (Exploration & Fossils)
- Exploration: Variation in organisms when isolated; separate populations change over time, this may lead to speciation.
- Fossils: Record of past organisms, which may represent organisms that didn't survive, or represent missing links in evolutionary history
Evidence for Evolution (Homologous Structures)
- Homologous Structures: Structures with same origin, but different functions in divergent organisms. Example: bat wing and human arm (same evolutionary origin)
- Analogous Structures: Similar structures, but different origin. Example: dolphin fin and shark fin (do not share the same evolutionary origin)
Evidence for Evolution (Vestigial, Embryological, and Genetic)
- Vestigial Structures: Structures no longer used in same way as in ancestors.
- Embryological: Similar development patterns among organisms, particularly in early stages.
- Molecular Markers: Genetic similarities between related organisms.
Evolution, Selection, and Adaptation (Part 2)
- Closest relative to humans: Chimpanzee, with only 1.6% difference in DNA
- Study of evolutionary relationships and aid in choosing animals for biomedical research; rats/mice used over chimpanzees
1.5 Human Structure
- Expected Learning Outcomes: List levels of human structure from complex to simple, discuss reductionistic and holistic viewpoints to understand human form and function, and discuss the clinical significance of anatomical variation among humans.
Hierarchy of Complexity (Level 1)
- Organism composed of organ systems
- Organ systems made of organs
- Organs made of tissues
- Tissues made of cells
- Cells are made of organelles
- Organelles are made of molecules
- Molecules made of atoms
Hierarchy of Complexity (Level 2)
- Reductionism: Studying simple components to understand complex systems; essential to scientific thinking.
- Holism: Emergent properties of whole organisms cannot be predicted from the separate parts; treat patient not only the disease
Anatomical Variation
- No two humans are exactly alike; anatomy books show common organization but variation exists
- Individuals may lack specific muscles or have atypical numbers of vertebrae or organs.
- Some individuals show situs inversus (left-right reversal of organs
1.6 Human Function
- Expected Learning Outcomes: State characteristics of living organisms, explain physiological variation among individuals, define homeostasis and its relevance; negative feedback mechanisms, its role in homeostasis, giving examples.
Characteristics of Life (Part 1)
- Organization - living things are more highly organized
- Cellular composition- living matter compartmentalized
- Metabolism- internal chemical reactions
- Responsiveness/Irritability - ability to react to stimulus
- Movement - movement either of organism or components
Characteristics of Life (Part 2)
- Homeostasis- stable internal conditions
- Development- differentiation & growth
- Reproduction - copying and passing on genes
- Evolution - changes of genes
Physiological Variation
- Factors influence physiological values: sex, age, diet, weight, physical activity, genetics, and environment.
- Typical physiological values for reference (e.g., reference man vs. woman).
- Failure to consider normal variation can lead to inappropriate treatment.
Negative Feedback and Homeostasis (Part 1)
- Homeostasis is the ability to maintain stable internal conditions.
- Negative feedback allows dynamic equilibrium around a set point, by altering the initial change.
Negative Feedback and Homeostasis (Part 2)
- Homeostasis in body temperature; examples of regulation of temperature using negative feedback (sweating or shivering)
- Mechanism and Components: Receptor(senses the change) ➞ Integrating center(Processes the sensory info) ➞ Effector(response to maintain homeostasis)
Positive Feedback and Rapid Change
- Self-amplifying cycle leads to a greater change in the same direction
- Feedback loop repeats, change produces more change
- Normal way of producing rapid changes, such as childbirth, blood clotting.
- Sometimes dangerous, for example, runaway fever
Gradients and Flow
- Gradient is a difference in chemical concentration, charge, temperature or pressure between two points.
- Materials tend to flow down gradients. Example: blood flows from high to low pressure.
- Moving 'up the gradient' requires metabolic energy.
1.7 The Language of Medicine
- Expected Learning Outcomes: Explain why medical terminology is based on Greek/Latin, recognize eponyms, describe efforts for uniform anatomical terminology, break terms into elements.
History of Anatomical Terminology
- About 90% of current medical terms have Greek/Latin roots; reflecting ancient origins.
- Renaissance progress brought confusion (different naming for the same structures in different countries)
- Anatomists created worldwide conventions for naming; avoiding eponyms, introducing Latin names, and providing equivalents.
- 1998: Terminologia Anatomica (TA), using Latin names and widely adopted by anatomists.
Analyzing Medical Terms
- Terminology based on word elements;
- Lexicon of specialized words.
- Scientists use one root (stem) with a core meaning, with combining vowels connecting roots
- Prefixes and suffixes can modify meaning
Plurals, Adjectives, & Possessive Forms
- Plural forms vary. Examples: cortex-cortices, corpus-corpora
- Adjectives often modify nouns. Example: Biceps brachii
- Adjectival forms can be different from noun forms. Example: brachium (n.) vs. brachii (adj.).
The Importance of Spelling
- Accurate spelling is paramount in healthcare; small errors can have significant consequences.
- Many medical terms share similar spellings but have entirely different meanings.
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Description
Explore the foundational themes of Anatomy and Physiology in this quiz. Learn about the history, the relationship between structure and function, and the various methods of studying human anatomy. This chapter sets the groundwork for advanced healthcare education and understanding human biology.