Analyzing Unknown Drug Samples

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How should an unknown drug sample be analyzed in the lab?

By performing a preliminary analysis followed by a confirmatory analysis (correct)
By performing a preliminary analysis only and not conducting a confirmatory analysis
By skipping the confirmatory analysis and directly performing a preliminary analysis
By skipping the preliminary analysis and directly performing a confirmatory analysis

What is the purpose of the final confirmatory analysis for an unknown drug sample?

To determine the quantity of the drug in the sample
To definitively identify the drug in the sample (correct)
To assess the purity of the drug in the sample
To gather initial information about the drug

What is the recommended approach for analyzing an unknown drug sample from the time it arrives in the lab?

Performing a confirmatory analysis only
Performing a preliminary analysis first, followed by a confirmatory analysis (correct)
Performing a confirmatory analysis first, followed by a preliminary analysis
Performing a preliminary analysis only

What are the steps involved in analyzing an unknown drug sample from the time it arrives in the lab through final confirmatory analysis?

<ol> <li>Sample receipt and documentation, 2. Preliminary testing, 3. Sample preparation, 4. Instrumental analysis, 5. Data interpretation and analysis, 6. Final confirmatory analysis.</li> </ol> Signup and view all the answers

Why is it important to properly document the receipt of an unknown drug sample in the lab?

Proper documentation of sample receipt ensures traceability and integrity of the sample, which is crucial in maintaining chain of custody and preserving the evidentiary value of the sample. Signup and view all the answers

What is the purpose of the final confirmatory analysis for an unknown drug sample?

The purpose of the final confirmatory analysis is to conclusively identify and quantify the presence of specific drugs or compounds in the sample, providing legally defensible results. Signup and view all the answers

Explain the similarities between liquid-liquid extraction and solid phase extraction.

Both liquid-liquid extraction and solid phase extraction are sample preparation techniques used in analytical chemistry. They both involve the separation of compounds from a mixture based on their physical and chemical properties. Both techniques are commonly used to isolate and concentrate analytes from complex matrices before analysis. Signup and view all the answers

Explain the differences between liquid-liquid extraction and solid phase extraction.

The main difference between liquid-liquid extraction and solid phase extraction is the type of phase used for extraction. In liquid-liquid extraction, two immiscible liquid phases are used, typically an organic solvent and an aqueous phase. The target analytes partition between these two phases based on their solubility. In solid phase extraction, a solid sorbent material is used to selectively retain the analytes while the unwanted components are washed away. The retained analytes are then eluted for further analysis. Signup and view all the answers

How does liquid-liquid extraction function?

Liquid-liquid extraction functions by taking advantage of the differential solubility of analytes in two immiscible liquid phases. The sample is mixed with an organic solvent and an aqueous phase. The target analytes partition between these two phases based on their solubility. After separation, the organic phase containing the analytes of interest is collected and further processed for analysis. Signup and view all the answers

How does solid phase extraction function?

Solid phase extraction functions by selectively retaining the target analytes on a solid sorbent material while the unwanted components are washed away. The sample is loaded onto a solid phase extraction cartridge or disk containing the sorbent material. The analytes of interest adsorb onto the sorbent while the interfering compounds pass through. After washing away the unwanted components, the retained analytes are eluted from the sorbent for subsequent analysis. Signup and view all the answers

Which one of these is a similarity between liquid-liquid extraction and solid phase extraction?

Both methods rely on the principle of partitioning (A) Signup and view all the answers

Which one of these is a difference between liquid-liquid extraction and solid phase extraction?

Liquid-liquid extraction uses a solid support, while solid phase extraction uses a liquid support (D) Signup and view all the answers

How does liquid-liquid extraction function?

By partitioning analytes between two immiscible liquid phases (D) Signup and view all the answers

What are the steps involved in the typical analysis protocol for an unknown drug sample?

The steps involved in the typical analysis protocol for an unknown drug sample include preliminary visual examination, weighing of evidence, selection of representative samples, screening tests, confirmatory tests, and quantitation if necessary. Signup and view all the answers

What are the steps involved in marijuana analysis?

The steps involved in marijuana analysis include observation under a stereomicroscope for cystolith hairs, Duquenois-Levine color test, thin layer chromatography, and possibly a confirmatory test for THC or other cannabinoids. Signup and view all the answers

What tests can be performed on liquids and residues in syringes for drug analysis?

Liquids and residues in syringes can be subjected to color tests, thin layer chromatography, UV spectroscopy as screening procedures, followed by GC-MS confirmation. Signup and view all the answers

Analyzing Unknown Drug Samples

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Questions and Answers

How should an unknown drug sample be analyzed in the lab?

What is the purpose of the final confirmatory analysis for an unknown drug sample?

What is the recommended approach for analyzing an unknown drug sample from the time it arrives in the lab?

What are the steps involved in analyzing an unknown drug sample from the time it arrives in the lab through final confirmatory analysis?

Why is it important to properly document the receipt of an unknown drug sample in the lab?

What is the purpose of the final confirmatory analysis for an unknown drug sample?

Explain the similarities between liquid-liquid extraction and solid phase extraction.

Explain the differences between liquid-liquid extraction and solid phase extraction.

How does liquid-liquid extraction function?

How does solid phase extraction function?

Which one of these is a similarity between liquid-liquid extraction and solid phase extraction?

Which one of these is a difference between liquid-liquid extraction and solid phase extraction?

How does liquid-liquid extraction function?

What are the steps involved in the typical analysis protocol for an unknown drug sample?

What are the steps involved in marijuana analysis?

What tests can be performed on liquids and residues in syringes for drug analysis?

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