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Questions and Answers
What is the name of the chemical formula of acetaminophen?
What is the name of the chemical formula of acetaminophen?
What type of analysis uses only 5 mg of a sample?
What type of analysis uses only 5 mg of a sample?
What is the name of the first pharmacopeia in the US?
What is the name of the first pharmacopeia in the US?
In what year was the first combined USP-NF published?
In what year was the first combined USP-NF published?
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What type of analysis involves the accurate measurement of weight?
What type of analysis involves the accurate measurement of weight?
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What is an example of an optical method of analysis?
What is an example of an optical method of analysis?
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What is the reference standard for acetaminophen?
What is the reference standard for acetaminophen?
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What is the purpose of a pharmacopeial monograph?
What is the purpose of a pharmacopeial monograph?
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What is the range for physical tests and determinations, microbiological tests, chemical tests and assays, and biological tests and assays?
What is the range for physical tests and determinations, microbiological tests, chemical tests and assays, and biological tests and assays?
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What type of information is provided in the range of 1000 to 1999?
What type of information is provided in the range of 1000 to 1999?
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Where are monographs for dietary supplements and ingredients found?
Where are monographs for dietary supplements and ingredients found?
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What is the purpose of a monograph?
What is the purpose of a monograph?
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What is included in the USP-NF?
What is included in the USP-NF?
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What is the purpose of a reference standard in a monograph?
What is the purpose of a reference standard in a monograph?
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What type of information is included in a monograph?
What type of information is included in a monograph?
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What is the purpose of identification tests in a monograph?
What is the purpose of identification tests in a monograph?
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Who published the First National Formulary in 1820?
Who published the First National Formulary in 1820?
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In which year was the title of the National Formulary designated by the Federal Pure Food and Drug Act?
In which year was the title of the National Formulary designated by the Federal Pure Food and Drug Act?
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What is the primary purpose of the General Notices Section in USP?
What is the primary purpose of the General Notices Section in USP?
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What is the frequency of USP revision and publication since 2002?
What is the frequency of USP revision and publication since 2002?
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What is the significance of the year 1975 in the history of USP-NF?
What is the significance of the year 1975 in the history of USP-NF?
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What is the topic of the 6th section of the General Notices in USP?
What is the topic of the 6th section of the General Notices in USP?
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What is the date of the Department Order that declared the Phil Pharmacopeia as the official book of standards and reference for pharmaceutical products and crude plant drugs in the Philippines?
What is the date of the Department Order that declared the Phil Pharmacopeia as the official book of standards and reference for pharmaceutical products and crude plant drugs in the Philippines?
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In what year was the first British Pharmacopeia published?
In what year was the first British Pharmacopeia published?
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What is the frequency of revision of the British Pharmacopeia?
What is the frequency of revision of the British Pharmacopeia?
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In what year was the International Pharmacopeia published by the World Health Organization (WHO)?
In what year was the International Pharmacopeia published by the World Health Organization (WHO)?
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What is the name of the first American formulary compiled by General William Brown?
What is the name of the first American formulary compiled by General William Brown?
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Who were the key figures involved in the development of the first US Pharmacopeia?
Who were the key figures involved in the development of the first US Pharmacopeia?
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What is the primary principle of Volumetric Analysis?
What is the primary principle of Volumetric Analysis?
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Which of the following is NOT a classical method of analysis?
Which of the following is NOT a classical method of analysis?
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What is the term used to describe the process of reacting a substance with another substance to form a precipitate?
What is the term used to describe the process of reacting a substance with another substance to form a precipitate?
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Which of the following types of analysis involves the measurement of weight?
Which of the following types of analysis involves the measurement of weight?
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What is the term used to describe the process of reacting a substance with another substance of known concentration?
What is the term used to describe the process of reacting a substance with another substance of known concentration?
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Which of the following is an instrumental method of analysis?
Which of the following is an instrumental method of analysis?
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Study Notes
Methods of Analysis
- Classified into three categories: Classical, Instrumental, and Misc
- Classical methods include Volumetric and Gravimetric analysis
- Volumetric analysis involves measuring the volume of a solution of known concentration required to react with the desired constituent
- Gravimetric analysis involves accurate measurement of weight by making it react quantitatively with another substance, usually a precipitant
Pharmacopeia
- A book of standards and reference for pharmaceutical products and crude plant drugs
- Examples: British Pharmacopeia (BP), United States Pharmacopeia (USP), International Pharmacopeia (IP), and European Pharmacopeia (EP)
- History of USP:
- First US Pharmacopeia published in 1820
- First National Formulary (NF) published in 1888
- President Theodore Roosevelt signed the first Federal Pure Food and Drug Act in 1906, establishing legal standards for medical and pharmaceutic substances
- USP acquired NF and Drug Standards Laboratory from APhA in 1975
- First combined USP-NF published in 1980
- USP revised and published annually, made official every 1st of May each year
Parts of USP
- General Notices: presents basic assumptions, definitions, and default conditions for the interpretation and application of USP and NF
- General Chapters:
- Enforceable chapters (1-999) for physical tests, microbiological tests, chemical tests, and assays
- General information chapters (1000-1999) with no mandatory requirement
- Chapters above 2000 apply to dietary ingredients or supplements
- Monograph: provides a specification by way of a name, definition, description, tests, procedures, and acceptance criteria, and sometimes packaging and labeling requirements
- Examples of General Chapters: Weights and Balances, Alcohol Determination, Melting Range or Temperature, etc.
Parts of a Monograph
- Chemical structure and formula
- Purity rubric
- Packaging and storage
- Reference standard
- Identification tests
- Corresponding tests for chemical and physical constants
- Assay procedure
- Water content
Examples of Monographs
- Acetaminophen monograph:
- Chemical structure and formula
- Identification test
- Assay
- Test for impurities
- Specific test
- Packaging and storage
- Reference standard
Review Questions
- Microanalysis involves the use of only 5mg of a sample
- Gravimetric analysis involves the accurate measurement of weight
- Spectrophotometry is an example of an optical method of analysis
- The first pharmacopeia in the US is the Lititz Pharmacopeia
- The first combined USP-NF was published in 1980
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Description
This quiz covers various methods of analysis in analytical chemistry, including classical, instrumental, and miscellaneous techniques such as titration, spectrophotometry, and electroanalytical methods.
