Analytical Chemistry Methods

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Questions and Answers

What is the name of the chemical formula of acetaminophen?

C9H11NO2

C6H5NO2

C8H9NO2 (correct)

C10H13NO2

What type of analysis uses only 5 mg of a sample?

Spectrophotometry

Optical method

Gravimetric Analysis

Microanalysis (correct)

What is the name of the first pharmacopeia in the US?

National Formulary

Lititz Pharmacopeia (correct)

United States Pharmacopeia

British Pharmacopeia

In what year was the first combined USP-NF published?

1980 (C) Signup and view all the answers

What type of analysis involves the accurate measurement of weight?

Gravimetric Analysis (B) Signup and view all the answers

What is an example of an optical method of analysis?

Spectrophotometry (A) Signup and view all the answers

What is the reference standard for acetaminophen?

United States Pharmacopeia (A) Signup and view all the answers

What is the purpose of a pharmacopeial monograph?

To provide standards for the quality of a drug (B) Signup and view all the answers

What is the range for physical tests and determinations, microbiological tests, chemical tests and assays, and biological tests and assays?

1 to 999 (A) Signup and view all the answers

What type of information is provided in the range of 1000 to 1999?

General Information (C) Signup and view all the answers

Where are monographs for dietary supplements and ingredients found?

A separate section of the USP (D) Signup and view all the answers

What is the purpose of a monograph?

To provide a specification by way of a name, definition, description, tests, procedures, and acceptance criteria (D) Signup and view all the answers

What is included in the USP-NF?

A combination of the United States Pharmacopeia and the National Formulary (A) Signup and view all the answers

What is the purpose of a reference standard in a monograph?

To provide a standard against which a substance can be compared (C) Signup and view all the answers

What type of information is included in a monograph?

A range of information including chemical structure, chemical name, purity rubric, and more (A) Signup and view all the answers

What is the purpose of identification tests in a monograph?

To identify the substance and confirm its identity (B) Signup and view all the answers

Who published the First National Formulary in 1820?

American Pharmacists Association (C) Signup and view all the answers

In which year was the title of the National Formulary designated by the Federal Pure Food and Drug Act?

1906 (A) Signup and view all the answers

What is the primary purpose of the General Notices Section in USP?

To present basic assumptions and default conditions for USP and NF (C) Signup and view all the answers

What is the frequency of USP revision and publication since 2002?

Annually, effective every 1st of May (D) Signup and view all the answers

What is the significance of the year 1975 in the history of USP-NF?

USP acquired NF and Drug standards Laboratory from APhA (A) Signup and view all the answers

What is the topic of the 6th section of the General Notices in USP?

Prescribing and dispensing (D) Signup and view all the answers

What is the date of the Department Order that declared the Phil Pharmacopeia as the official book of standards and reference for pharmaceutical products and crude plant drugs in the Philippines?

March 29, 2004 (C) Signup and view all the answers

In what year was the first British Pharmacopeia published?

1864 (C) Signup and view all the answers

What is the frequency of revision of the British Pharmacopeia?

Annually (D) Signup and view all the answers

In what year was the International Pharmacopeia published by the World Health Organization (WHO)?

1951 (B) Signup and view all the answers

What is the name of the first American formulary compiled by General William Brown?

Lititz Pharmacopeia (C) Signup and view all the answers

Who were the key figures involved in the development of the first US Pharmacopeia?

Dr. Lyman Spalding, Dr. Samuel Mitchill, and Dr. William Brown (B) Signup and view all the answers

What is the primary principle of Volumetric Analysis?

Measurement of volume of a solution of known concentration (C) Signup and view all the answers

Which of the following is NOT a classical method of analysis?

Electroanalytical analysis (B) Signup and view all the answers

What is the term used to describe the process of reacting a substance with another substance to form a precipitate?

Precipitation (D) Signup and view all the answers

Which of the following types of analysis involves the measurement of weight?

Gravimetric analysis (C) Signup and view all the answers

What is the term used to describe the process of reacting a substance with another substance of known concentration?

Titration (A) Signup and view all the answers

Which of the following is an instrumental method of analysis?

Spectrophotometry (B) Signup and view all the answers

Study Notes

Methods of Analysis

Classified into three categories: Classical, Instrumental, and Misc
Classical methods include Volumetric and Gravimetric analysis
Volumetric analysis involves measuring the volume of a solution of known concentration required to react with the desired constituent
Gravimetric analysis involves accurate measurement of weight by making it react quantitatively with another substance, usually a precipitant

Pharmacopeia

A book of standards and reference for pharmaceutical products and crude plant drugs
Examples: British Pharmacopeia (BP), United States Pharmacopeia (USP), International Pharmacopeia (IP), and European Pharmacopeia (EP)
History of USP:
- First US Pharmacopeia published in 1820
- First National Formulary (NF) published in 1888
- President Theodore Roosevelt signed the first Federal Pure Food and Drug Act in 1906, establishing legal standards for medical and pharmaceutic substances
- USP acquired NF and Drug Standards Laboratory from APhA in 1975
- First combined USP-NF published in 1980
- USP revised and published annually, made official every 1st of May each year

Parts of USP

General Notices: presents basic assumptions, definitions, and default conditions for the interpretation and application of USP and NF
General Chapters:
- Enforceable chapters (1-999) for physical tests, microbiological tests, chemical tests, and assays
- General information chapters (1000-1999) with no mandatory requirement
- Chapters above 2000 apply to dietary ingredients or supplements
Monograph: provides a specification by way of a name, definition, description, tests, procedures, and acceptance criteria, and sometimes packaging and labeling requirements
Examples of General Chapters: Weights and Balances, Alcohol Determination, Melting Range or Temperature, etc.

Parts of a Monograph

Chemical structure and formula
Purity rubric
Packaging and storage
Reference standard
Identification tests
Corresponding tests for chemical and physical constants
Assay procedure
Water content

Examples of Monographs

Acetaminophen monograph:
- Chemical structure and formula
- Identification test
- Assay
- Test for impurities
- Specific test
- Packaging and storage
- Reference standard

Review Questions

Microanalysis involves the use of only 5mg of a sample
Gravimetric analysis involves the accurate measurement of weight
Spectrophotometry is an example of an optical method of analysis
The first pharmacopeia in the US is the Lititz Pharmacopeia
The first combined USP-NF was published in 1980

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Description

This quiz covers various methods of analysis in analytical chemistry, including classical, instrumental, and miscellaneous techniques such as titration, spectrophotometry, and electroanalytical methods.