Lecture 3 biochem MCQ
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Questions and Answers

Which part of the adrenal gland is of mesodermal origin?

  • Medulla
  • Bladder
  • Cortex (correct)
  • Fat layer
  • Which hormones are produced by the adrenal cortex?

  • Estrogens
  • Catecholamines
  • Steroid hormones
  • Glucocorticoids, Mineralocorticoids, Androgens (correct)
  • Which part of the adrenal gland is of neural crest origin?

  • Bladder
  • Cortex
  • Medulla (correct)
  • Fat layer
  • Which hormones are produced by the adrenal medulla?

    <p>Catecholamines</p> Signup and view all the answers

    Which of the following accurately describes the site of synthesis for cortisol?

    <p>Adrenal cortex</p> Signup and view all the answers

    What is the influence of stress on cortisol secretion?

    <p>Stress increases cortisol secretion</p> Signup and view all the answers

    How would you investigate a subject suspected of having Addison's disease?

    <p>Synacthen stimulation test</p> Signup and view all the answers

    What are some of the metabolic manifestations of Cushing's disease?

    <p>Hyperglycemia and weight gain</p> Signup and view all the answers

    Which of the following is a cause of hypercortisolism?

    <p>Long term therapy with glucocorticoids</p> Signup and view all the answers

    Which of the following is a manifestation of primary Addison's disease?

    <p>Hyperpigmentation</p> Signup and view all the answers

    What is the purpose of the Synacthen stimulation test?

    <p>To test responsiveness of adrenal glands to stimulation</p> Signup and view all the answers

    What is the normal result of the Synacthen stimulation test?

    <p>Plasma cortisol increases by 200 nmol/L</p> Signup and view all the answers

    Which of the following is a reference interval for salivary cortisol in adults in the afternoon?

    <p>&lt; 9.9 nmol/L</p> Signup and view all the answers

    What is the reference interval for salivary cortisol in neonatal babies in the morning?

    <p>&lt; 94.3 nmol/L</p> Signup and view all the answers

    Which of the following is a possible cause of Cushing's disease?

    <p>Pituitary secretion</p> Signup and view all the answers

    What is the recommended storage temperature for saliva samples for cortisol measurement?

    <p>-20C</p> Signup and view all the answers

    Which of the following is true about the measurement of ACTH Circadian rhythm?

    <p>It requires immediate centrifugation at 4°C and then freezing.</p> Signup and view all the answers

    What is the most common form of steroid hormone found in plasma?

    <p>Bound to Albumin</p> Signup and view all the answers

    How do unbound (free) steroid hormones enter cells?

    <p>They diffuse across cell membranes.</p> Signup and view all the answers

    What is the role of heat shock protein 90 (HSP 90) in the complex with unoccupied receptors?

    <p>Prevent binding of unoccupied receptors to DNA.</p> Signup and view all the answers

    Which of the following is a test used to determine the cause of hypercortisolism in Cushing's syndrome?

    <p>Dexamethasone suppression test</p> Signup and view all the answers

    What is the normal result for a low dose overnight dexamethasone suppression test?

    <p>Suppression to &lt;190 nmol/L</p> Signup and view all the answers

    Which of the following is NOT a manifestation of Cushing's syndrome?

    <p>Hypothyroidism</p> Signup and view all the answers

    What is the primary cause of hypercortisolism in Cushing's syndrome?

    <p>Excessive production of cortisol by the adrenals</p> Signup and view all the answers

    Which process decreases the synthesis/release of hormones?

    <p>Steroid Hormone Inactivation/Excretion</p> Signup and view all the answers

    Where does metabolism to water soluble forms of steroids mostly occur?

    <p>Liver</p> Signup and view all the answers

    What does the binding of the glucocorticoid receptor complex inhibit?

    <p>Activation of gene transcription by NFkB</p> Signup and view all the answers

    What is the primary organ responsible for excreting water soluble forms of steroids?

    <p>Kidney</p> Signup and view all the answers

    What is the process that removes/inactivates hormones?

    <p>Steroid Hormone Inactivation &amp; Excretion</p> Signup and view all the answers

    What is the role of NFkB in gene transcription of the IL6 gene?

    <p>Activates gene transcription</p> Signup and view all the answers

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