Lecture 3 biochem MCQ
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Questions and Answers

Which part of the adrenal gland is of mesodermal origin?

  • Medulla
  • Bladder
  • Cortex (correct)
  • Fat layer

Which hormones are produced by the adrenal cortex?

  • Estrogens
  • Catecholamines
  • Steroid hormones
  • Glucocorticoids, Mineralocorticoids, Androgens (correct)

Which part of the adrenal gland is of neural crest origin?

  • Bladder
  • Cortex
  • Medulla (correct)
  • Fat layer

Which hormones are produced by the adrenal medulla?

<p>Catecholamines (A)</p> Signup and view all the answers

Which of the following accurately describes the site of synthesis for cortisol?

<p>Adrenal cortex (C)</p> Signup and view all the answers

What is the influence of stress on cortisol secretion?

<p>Stress increases cortisol secretion (C)</p> Signup and view all the answers

How would you investigate a subject suspected of having Addison's disease?

<p>Synacthen stimulation test (C)</p> Signup and view all the answers

What are some of the metabolic manifestations of Cushing's disease?

<p>Hyperglycemia and weight gain (B)</p> Signup and view all the answers

Which of the following is a cause of hypercortisolism?

<p>Long term therapy with glucocorticoids (D)</p> Signup and view all the answers

Which of the following is a manifestation of primary Addison's disease?

<p>Hyperpigmentation (D)</p> Signup and view all the answers

What is the purpose of the Synacthen stimulation test?

<p>To test responsiveness of adrenal glands to stimulation (C)</p> Signup and view all the answers

What is the normal result of the Synacthen stimulation test?

<p>Plasma cortisol increases by 200 nmol/L (D)</p> Signup and view all the answers

Which of the following is a reference interval for salivary cortisol in adults in the afternoon?

<p>&lt; 9.9 nmol/L (A)</p> Signup and view all the answers

What is the reference interval for salivary cortisol in neonatal babies in the morning?

<p>&lt; 94.3 nmol/L (C)</p> Signup and view all the answers

Which of the following is a possible cause of Cushing's disease?

<p>Pituitary secretion (C)</p> Signup and view all the answers

What is the recommended storage temperature for saliva samples for cortisol measurement?

<p>-20C (B)</p> Signup and view all the answers

Which of the following is true about the measurement of ACTH Circadian rhythm?

<p>It requires immediate centrifugation at 4°C and then freezing. (C)</p> Signup and view all the answers

What is the most common form of steroid hormone found in plasma?

<p>Bound to Albumin (A)</p> Signup and view all the answers

How do unbound (free) steroid hormones enter cells?

<p>They diffuse across cell membranes. (D)</p> Signup and view all the answers

What is the role of heat shock protein 90 (HSP 90) in the complex with unoccupied receptors?

<p>Prevent binding of unoccupied receptors to DNA. (D)</p> Signup and view all the answers

Which of the following is a test used to determine the cause of hypercortisolism in Cushing's syndrome?

<p>Dexamethasone suppression test (C)</p> Signup and view all the answers

What is the normal result for a low dose overnight dexamethasone suppression test?

<p>Suppression to &lt;190 nmol/L (C)</p> Signup and view all the answers

Which of the following is NOT a manifestation of Cushing's syndrome?

<p>Hypothyroidism (B)</p> Signup and view all the answers

What is the primary cause of hypercortisolism in Cushing's syndrome?

<p>Excessive production of cortisol by the adrenals (C)</p> Signup and view all the answers

Which process decreases the synthesis/release of hormones?

<p>Steroid Hormone Inactivation/Excretion (C)</p> Signup and view all the answers

Where does metabolism to water soluble forms of steroids mostly occur?

<p>Liver (C)</p> Signup and view all the answers

What does the binding of the glucocorticoid receptor complex inhibit?

<p>Activation of gene transcription by NFkB (D)</p> Signup and view all the answers

What is the primary organ responsible for excreting water soluble forms of steroids?

<p>Kidney (B)</p> Signup and view all the answers

What is the process that removes/inactivates hormones?

<p>Steroid Hormone Inactivation &amp; Excretion (B)</p> Signup and view all the answers

What is the role of NFkB in gene transcription of the IL6 gene?

<p>Activates gene transcription (C)</p> Signup and view all the answers

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