Questions and Answers
Which of the following are indications for Amoxapine (Asendin)? (Select all that apply)
What is the drug classification of Amoxapine (Asendin)?
What are some side effects of Amoxapine (Asendin)? (Select all that apply)
What does Amoxapine (Asendin) potentiate?
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Amoxapine (Asendin) is contraindicated in patients with angle closure glaucoma.
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What should be monitored as part of nursing responsibility when administering Amoxapine?
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What should be done if a patient is taking antidepressants while on Amoxapine?
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It is safe to use Amoxapine (Asendin) in pediatric patients without any concerns.
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Amoxapine may lead to __________, which is a serious condition.
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Match the following conditions with their relation to Amoxapine (Asendin):
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Study Notes
Amoxapine (Asendin) Overview
- Amoxapine is used to treat depression, anxiety, insomnia, and chronic pain.
- Classified as an antidepressant, it's designated as Category C for pregnancy and is typically administered orally (PO).
Key Side Effects
- Potentially life-threatening conditions include Neuroleptic Malignant Syndrome (NMS) and extrapyramidal symptoms.
- Common side effects: fatigue, sedation, blurred vision, dry eyes and mouth, arrhythmias, and lower blood pressure.
- Other effects include constipation, increased appetite, weight gain, testicular swelling, urinary retention, photosensitivity, and sexual dysfunction.
Nursing Responsibilities
- Monitor mental status and vital signs including blood pressure.
- Watch for extrapyramidal symptoms (EPS), tardive dyskinesia (TD), neuroleptic malignant syndrome (NMS), and sexual dysfunction.
- Regular complete blood count (CBC) checks are recommended.
Mechanism of Action
- Amoxapine works by potentiating serotonin and norepinephrine, exhibiting anticholinergic properties.
Contraindications and Cautions
- Contraindicated in patients with angle closure glaucoma, prolonged QT interval, heart failure, or arrhythmias.
- Caution advised for patients with cardiovascular disease, prostatic hyperplasia, history of seizures, and those at increased risk for suicidality.
- During pregnancy, assess if benefits outweigh risks; safety in pediatric patients is not established.
Drug Interactions
- Dosage adjustments may be necessary when used with other antidepressants, phenothiazines, carbamazepine, or class 1C antiarrhythmics.
- MAOIs can lead to lower blood pressure and heightened heart rate, increasing the risk of fatal outcomes.
- Concomitant use with cimetidine, quinidine, amiodarone, or SSRIs can enhance toxicity.
- Avoid combining with clonidine due to potential hypertensive crises, and be mindful of increased levodopa levels when taken together.
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Description
Explore the various aspects of Amoxapine, including its uses, side effects, and nursing responsibilities. This quiz covers crucial information about monitoring patients and understanding the mechanism of action of this antidepressant. Ideal for nursing students and healthcare professionals.
