AML Morphological Features: Auer Rods
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Questions and Answers

What percentage of NEC are BM maturing monocytic cells?

  • ≥ 30%
  • > 10%
  • ≤ 10% (correct)
  • 20%

    • What is the normal value of lysozyme estimation in serum?

  • 5.5 µg/mL
  • 11.5 ± 4 µg/mL (correct)
  • 20.5 µg/mL
  • 15.5 µg/mL

    • What type of AML is characterized by the presence of maturation?

  • AML M1
  • AML M4
  • AML M2 (correct)
  • AML M3

    • What is the minimum value of lysozyme estimation that should be exceeded in serum?

    <p>33.5 µg/mL</p> Signup and view all the answers

    What is the minimum percentage of blasts required for ANC in AML?

    <p>30%</p> Signup and view all the answers

    Which of the following is a criteria for diagnosing AML M1?

    <p>Blasts ≥ 30% of ANC</p> Signup and view all the answers

    What is the normal value of lysozyme estimation in urine?

    <p>2.5 µg/mL</p> Signup and view all the answers

    What is the subtype of AML that exhibits minimal maturation?

    <p>AML M1</p> Signup and view all the answers

    What is the minimum value of lysozyme estimation that should be exceeded in urine?

    <p>7.5 µg/mL</p> Signup and view all the answers

    What is the purpose of estimating lysozyme levels?

    <p>Not mentioned in the content</p> Signup and view all the answers

    What are Auer rods primarily composed of?

    <p>Abnormal azurophilic granules</p> Signup and view all the answers

    What is the characteristic staining pattern of Auer rods?

    <p>Red</p> Signup and view all the answers

    In which type of cells are Auer rods typically seen?

    <p>Myeloblasts</p> Signup and view all the answers

    What is the significance of Auer rods in AML diagnosis?

    <p>They are a diagnostic feature</p> Signup and view all the answers

    What is the cellular component that Auer rods represent?

    <p>Abnormal azurophilic granules</p> Signup and view all the answers

    What percentage of ANC must be composed of blasts to meet the diagnostic criteria for AML?

    <p>30%</p> Signup and view all the answers

    In AML-M5a (Monoblastic), what percentage of the bone marrow monocytic component must be composed of monoblasts?

    <p>80%</p> Signup and view all the answers

    What percentage of NEC must be composed of blasts to meet the diagnostic criteria for AML?

    <p>30%</p> Signup and view all the answers

    Which of the following is a characteristic feature of AML-M5a (Monoblastic)?

    <p>High percentage of monoblasts in the bone marrow monocytic component</p> Signup and view all the answers

    What type of cells does Sudan Black B bind to?

    <p>Granulocytes, eosinophils, and some monocytes</p> Signup and view all the answers

    What is the characteristic feature of blasts in AML?

    <p>Presence of Auer rods</p> Signup and view all the answers

    What is the property of Sudan Black B?

    <p>Lipophilic</p> Signup and view all the answers

    In which type of leukemia is Sudan Black B typically positive?

    <p>AML</p> Signup and view all the answers

    What is the result of Sudan Black B in ALL?

    <p>Negative</p> Signup and view all the answers

    What type of granule component does Sudan Black B bind to?

    <p>Undefined</p> Signup and view all the answers

    Study Notes

    AML Classification

    • AML is classified based on morphological features, including Auer rods.

    Auer Rods

    • Auer rods are distinctive red-staining rods seen in the cytoplasm of myeloblasts.
    • They represent abnormal azurophilic granules.

    AML M1

    • Criteria for diagnosis of AML M1 include:
      • Blasts ≥ 30% of ANC.
      • Blasts ≥ 30% of NEC.
      • BM maturing monocytic cells (promonocytes & monocytes) ≤ 10% of NEC.

    AML M2

    • AML M2 is characterized by AML with maturation.

    AML M5a (Monoblastic)

    • Monoblasts ≥ 80% of BM monocytic component.

    Cytochemistry

    • Sudan Black B (SBB) is a lipophilic dye that binds irreversibly to an undefined granule component in:
      • Granulocytes.
      • Eosinophils.
      • Some monocytes.
    • SBB is:
      • Positive in AML M1 – M4.
      • Negative in ALL.

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    Acute Leukemia: Morphology and Cytochemistry PDF

    Description

    This quiz covers the morphological features of Acute Myeloid Leukemia (AML), specifically Auer rods, which are distinctive red staining rods seen in the cytoplasm of myeloblasts. Learn about abnormal azurophilic granules and their significance in AML diagnosis.

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