Podcast
Questions and Answers
What percentage of NEC are BM maturing monocytic cells?
What percentage of NEC are BM maturing monocytic cells?
- ≥ 30%
- > 10%
- ≤ 10% (correct)
- 20%
What is the normal value of lysozyme estimation in serum?
What is the normal value of lysozyme estimation in serum?
- 5.5 µg/mL
- 11.5 ± 4 µg/mL (correct)
- 20.5 µg/mL
- 15.5 µg/mL
What type of AML is characterized by the presence of maturation?
What type of AML is characterized by the presence of maturation?
- AML M1
- AML M4
- AML M2 (correct)
- AML M3
What is the minimum value of lysozyme estimation that should be exceeded in serum?
What is the minimum value of lysozyme estimation that should be exceeded in serum?
What is the minimum percentage of blasts required for ANC in AML?
What is the minimum percentage of blasts required for ANC in AML?
Which of the following is a criteria for diagnosing AML M1?
Which of the following is a criteria for diagnosing AML M1?
What is the normal value of lysozyme estimation in urine?
What is the normal value of lysozyme estimation in urine?
What is the subtype of AML that exhibits minimal maturation?
What is the subtype of AML that exhibits minimal maturation?
What is the minimum value of lysozyme estimation that should be exceeded in urine?
What is the minimum value of lysozyme estimation that should be exceeded in urine?
What is the purpose of estimating lysozyme levels?
What is the purpose of estimating lysozyme levels?
What are Auer rods primarily composed of?
What are Auer rods primarily composed of?
What is the characteristic staining pattern of Auer rods?
What is the characteristic staining pattern of Auer rods?
In which type of cells are Auer rods typically seen?
In which type of cells are Auer rods typically seen?
What is the significance of Auer rods in AML diagnosis?
What is the significance of Auer rods in AML diagnosis?
What is the cellular component that Auer rods represent?
What is the cellular component that Auer rods represent?
What percentage of ANC must be composed of blasts to meet the diagnostic criteria for AML?
What percentage of ANC must be composed of blasts to meet the diagnostic criteria for AML?
In AML-M5a (Monoblastic), what percentage of the bone marrow monocytic component must be composed of monoblasts?
In AML-M5a (Monoblastic), what percentage of the bone marrow monocytic component must be composed of monoblasts?
What percentage of NEC must be composed of blasts to meet the diagnostic criteria for AML?
What percentage of NEC must be composed of blasts to meet the diagnostic criteria for AML?
Which of the following is a characteristic feature of AML-M5a (Monoblastic)?
Which of the following is a characteristic feature of AML-M5a (Monoblastic)?
What type of cells does Sudan Black B bind to?
What type of cells does Sudan Black B bind to?
What is the characteristic feature of blasts in AML?
What is the characteristic feature of blasts in AML?
What is the property of Sudan Black B?
What is the property of Sudan Black B?
In which type of leukemia is Sudan Black B typically positive?
In which type of leukemia is Sudan Black B typically positive?
What is the result of Sudan Black B in ALL?
What is the result of Sudan Black B in ALL?
What type of granule component does Sudan Black B bind to?
What type of granule component does Sudan Black B bind to?
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Study Notes
AML Classification
- AML is classified based on morphological features, including Auer rods.
Auer Rods
- Auer rods are distinctive red-staining rods seen in the cytoplasm of myeloblasts.
- They represent abnormal azurophilic granules.
AML M1
- Criteria for diagnosis of AML M1 include:
- Blasts ≥ 30% of ANC.
- Blasts ≥ 30% of NEC.
- BM maturing monocytic cells (promonocytes & monocytes) ≤ 10% of NEC.
AML M2
- AML M2 is characterized by AML with maturation.
AML M5a (Monoblastic)
- Monoblasts ≥ 80% of BM monocytic component.
Cytochemistry
- Sudan Black B (SBB) is a lipophilic dye that binds irreversibly to an undefined granule component in:
- Granulocytes.
- Eosinophils.
- Some monocytes.
- SBB is:
- Positive in AML M1 – M4.
- Negative in ALL.
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