Aminoglycoside Resistance and Beta-Lactam Antibiotic Synergy Quiz
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Questions and Answers

Which of the following is the definition of an antibiotic?

  • A chemical that has no effect on microorganisms
  • A chemical that kills or inhibits the growth of microorganisms
  • A chemical that promotes the growth of microorganisms
  • A chemical produced by a microorganism that kills or inhibits the growth of another microorganism (correct)

What is the consequence of antibiotic treatment on the gastrointestinal tract?

  • Increased risk of antibiotic-resistant organisms (correct)
  • Antibiotics have no effect on the gastrointestinal tract
  • No effect on antibiotic-resistant organisms
  • Decreased risk of antibiotic-resistant organisms

What is the lowest concentration that results in inhibition of visible growth in antibiotic susceptibility testing?

  • Minimum bactericidal concentration (MBC)
  • Maximum bactericidal concentration (MBC)
  • Minimum inhibitory concentration (MIC) (correct)
  • Maximum inhibitory concentration (MIC)

Which pathogen is most frequently acquired in hospitals?

<p>MRSA (B)</p> Signup and view all the answers

What is the proposed solution to combat antimicrobial resistance?

<p>Use antibiotics only when necessary (B)</p> Signup and view all the answers

What is combination therapy?

<p>Using two different antibiotics at the same time (B)</p> Signup and view all the answers

What is the main cause of resistance to antiviral drugs?

<p>Changes in the virus genome (B)</p> Signup and view all the answers

What is the main factor that promotes antimicrobial resistance?

<p>Exposure to microbes carrying resistance genes (C)</p> Signup and view all the answers

Which of the following is a common cause of bacterial resistance to penicillins?

<p>Heavy use of penicillins (A)</p> Signup and view all the answers

What is the main difference between cephalosporins and cephamycins?

<p>Cephalosporins contain oxygen in place of sulfur in the dihydrothiazine ring (C)</p> Signup and view all the answers

Which antibiotic is generally used against Mycobacterium tuberculosis?

<p>Rifampicin (D)</p> Signup and view all the answers

What is the mode of action of quinolones?

<p>They prevent supercoiling of DNA (D)</p> Signup and view all the answers

What is the spectrum of activity of sulfonamides and sulfones?

<p>Broad range activity against gram-positive and gram-negative bacteria (B)</p> Signup and view all the answers

What is the mode of action of trimethoprim?

<p>They bind to dihydrofolate reductase (B)</p> Signup and view all the answers

What is the mode of action of tetracyclines?

<p>They interfere with mRNA interaction with the 30S ribosome (A)</p> Signup and view all the answers

What is the first choice of treatment for infections caused by gram-negative bacilli?

<p>Aminoglycosides (D)</p> Signup and view all the answers

What is the mechanism of resistance for chloramphenicol?

<p>Acetylation reaction (D)</p> Signup and view all the answers

What is the mode of action of macrolides?

<p>They inhibit translocation (B)</p> Signup and view all the answers

Which enzyme is responsible for catalyzing the crosslinking of NAM and NAG in peptidoglycan?

<p>Transpeptidase (B)</p> Signup and view all the answers

What are penicillin-binding proteins (PBPs) and why are they important?

<p>PBPs are targets for penicillin and other beta-lactam antibiotics (B)</p> Signup and view all the answers

What are the three general mechanisms by which bacteria can become resistant to beta-lactam antibiotics?

<p>Prevention of interaction between the antibiotic and the target PBP, modification of the binding of the antibiotic to the PBP, hydrolysis of the antibiotic by bacterial enzymes (B)</p> Signup and view all the answers

What are beta-lactamase inhibitors and how do they work?

<p>Molecules that bind and inactivate beta-lactamase, allowing penicillins to enter the bacterial cell (A)</p> Signup and view all the answers

Which antibiotic therapy is used to prevent the emergence of resistant strains?

<p>Antimicrobial cocktails (C)</p> Signup and view all the answers

What is MRSA?

<p>A nosocomial pathogen (D)</p> Signup and view all the answers

What is the proposed solution to combat antimicrobial resistance?

<p>Use antimicrobial cocktails (D)</p> Signup and view all the answers

What is the mode of action of Rifampicin?

<p>Inhibits transcription process (B)</p> Signup and view all the answers

What is the mode of action of quinolones?

<p>Prevents supercoiling of DNA (D)</p> Signup and view all the answers

What is the spectrum of activity of Sulfonamides and Sulfones?

<p>Broad range activity against gram-positive and gram-negative bacteria (B)</p> Signup and view all the answers

What is the mode of action of Trimethoprim?

<p>Inhibits formation of tetrahydrofolic acid (A)</p> Signup and view all the answers

What is the mode of action of spectinomycin?

<p>It interferes with m-RNA interaction with the 30S ribosome (D)</p> Signup and view all the answers

What is the spectrum of activity of tetracyclines?

<p>Broad-spectrum against gram positive and some gram negative bacteria (B)</p> Signup and view all the answers

What is the mode of action of fusidic acid?

<p>It binds to elongation factor G (EF-G) and inhibits release of EF-G from the EF-G/GDP complex (C)</p> Signup and view all the answers

What is the mode of action of macrolides?

<p>They inhibit translocation (D)</p> Signup and view all the answers

What is the mode of action of vancomycin?

<p>It interferes with the formation of bridges in gram-positive bacteria. (A)</p> Signup and view all the answers

What is the mechanism of resistance for β-lactam antibiotics in gram-negative bacteria?

<p>No entrance through the outer membrane. (A)</p> Signup and view all the answers

What is the spectrum of activity of aminoglycosides?

<p>Active against most gram-positive bacteria and some gram-negative bacteria. (D)</p> Signup and view all the answers

What is the function of beta-lactamase inhibitors?

<p>They bind and inactivate beta-lactamase and allow penicillins to enter the bacterial cell without undergoing enzymatic degradation. (D)</p> Signup and view all the answers

What is the difference between an antibiotic and an antimicrobial agent?

<p>Antibiotics are natural substances produced by microorganisms, while antimicrobial agents are synthetic chemicals (D)</p> Signup and view all the answers

What is the consequence of antibiotic treatment on the gastrointestinal tract?

<p>It can lead to the growth of antibiotic-resistant organisms and C. difficile (A)</p> Signup and view all the answers

What are the five principal mechanisms of resistance to antibacterial drugs?

<p>Prevention of drug penetration, alteration and interference in conveying the drug, activation of efflux pumps, modification of the target site of antibiotic, enzymatic drug destruction or inactivation (C)</p> Signup and view all the answers

What is the main cause of bacterial resistance to penicillins?

<p>Heavy use of penicillins (D)</p> Signup and view all the answers

What is the difference between cephalosporins and cephamycins?

<p>Cephalosporins contain sulfur in the dihydrothiazine ring, while cephamycins contain oxygen (A)</p> Signup and view all the answers

What is the mechanism of action of carbapenems?

<p>They have a rapid bactericidal action and are stable to beta-lactamase hydrolysis (C)</p> Signup and view all the answers

What are the factors that promote antimicrobial resistance?

<p>Exposure to sub-optimal levels of antimicrobial, inappropriate antimicrobial use, spread of resistant microbes in hospitals, abuse of antibiotics in animals and foods (C)</p> Signup and view all the answers

Which pathogen is most frequently acquired in hospitals?

<p>Methicillin-Resistant Staphylococcus aureus (C)</p> Signup and view all the answers

What is the proposed solution to combat antimicrobial resistance?

<p>Use more narrow spectrum antibiotics (B)</p> Signup and view all the answers

What is combination therapy?

<p>Using multiple antimicrobials to treat an infection (B)</p> Signup and view all the answers

Which enzyme is responsible for catalyzing the crosslinking of NAM and NAG in peptidoglycan?

<p>Transpeptidase (A)</p> Signup and view all the answers

What is the mode of action of vancomycin?

<p>Inhibits proper cell wall synthesis in Gram-positive bacteria (D)</p> Signup and view all the answers

What is the mechanism of resistance for β-lactam antibiotics in gram-negative bacteria?

<p>No entrance through the outer membrane (C)</p> Signup and view all the answers

What is the spectrum of activity of aminoglycosides?

<p>Many gram-negative and some gram-positive bacteria (C)</p> Signup and view all the answers

What is the mode of action of aminoglycosides?

<p>They interfere with mRNA interaction with the 30S ribosome (B)</p> Signup and view all the answers

What is the spectrum of activity of tetracyclines?

<p>Broad-spectrum against gram positive and some gram negative bacteria (D)</p> Signup and view all the answers

What is the mode of action of chloramphenicol?

<p>They bind to the 50S ribosome and block the peptide extension (A)</p> Signup and view all the answers

What is the mode of action of macrolides?

<p>They inhibit translocation (B)</p> Signup and view all the answers

What is the mode of action of Rifampicin?

<p>It inhibits transcription process (A)</p> Signup and view all the answers

What is the spectrum of activity of Quinolones?

<p>Active against gram-positive and urinary tract infections (B)</p> Signup and view all the answers

What is the mode of action of Sulfonamides and Sulfones?

<p>They inhibit the synthesis of folic acid (D)</p> Signup and view all the answers

What is the mode of action of Trimethoprim?

<p>It inhibits the synthesis of folic acid (C)</p> Signup and view all the answers

Which antibiotic is active against most gram-positive bacteria such as staphylococci and streptococci?

<p>Penicillins (C)</p> Signup and view all the answers

What is the difference between cephalosporins and cephamycins?

<p>Cephamycins are more stable to beta-lactamase hydrolysis than cephalosporins (A)</p> Signup and view all the answers

What are the factors that promote antimicrobial resistance?

<p>Abuse of antibiotics in animals and foods (D)</p> Signup and view all the answers

What is the characteristic feature of carbapenems?

<p>They have a broad bacterial spectrum and a rapid bactericidal action (C)</p> Signup and view all the answers

Which microorganisms can proliferate in the gastrointestinal tract due to antibiotic treatment?

<p>Enterococcus (B)</p> Signup and view all the answers

What is the lowest concentration that kills 99.9% of the original inoculum in antibiotic susceptibility testing?

<p>Minimum bactericidal concentration (MBC) (C)</p> Signup and view all the answers

What are the principal mechanisms of resistance to antibacterial drugs?

<p>Activation of efflux pumps and rapid ejection of the drug (A)</p> Signup and view all the answers

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