Aminoglycosides: Aminocyclitols

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Questions and Answers

Which of the following is classified as an aminocyclitol antimicrobial?

Lincomycin
Amoxicillin
Spectinomycin (correct)
Doxycycline

Spectinomycin is often combined with lincomycin to:

Enhance its bactericidal effect against Gram-negative bacteria
Expand the spectrum of activity against Gram-positive aerobic and anaerobic bacteria (correct)
Improve its pharmacokinetics
Reduce the risk of resistance development

What is the primary mechanism of action of spectinomycin?

It inhibits protein synthesis

Spectinomycin is typically considered:

Narrow-spectrum (C) Signup and view all the answers

In which of the following conditions is spectinomycin used in small animals?

Tonsillitis, conjunctivitis, laryngitis, and pneumonia (B) Signup and view all the answers

In ruminants, spectinomycin is used to treat respiratory diseases caused by which pathogens?

Mannheimia hemolytica, Pasteurella multocida, and Histophilus somni (B) Signup and view all the answers

In swine, spectinomycin combined with lincomycin is used to treat:

Swine dysentery and porcine proliferative enteropathy (A) Signup and view all the answers

Spectinomycin is used in poultry to control:

Pasteurellosis (fowl cholera), salmonellosis, and Mycoplasma synoviae (A) Signup and view all the answers

Which statement is TRUE about spectinomycin?

It has widespread natural resistance in many enteric bacteria (D) Signup and view all the answers

What are the three main clinical uses of aminocyclitols?

To treat mycoplasma infections, diseases caused by enterobacteriaceae and respiratory diseases caused by Gram - bacteria Signup and view all the answers

Flashcards

What is Spectinomycin?

An antimicrobial drug classified as an aminocyclitol.

Why combine Spectinomycin and Lincomycin?

To broaden its effect against Gram-positive aerobic and anaerobic bacteria.