Amino Acid Metabolism Quiz
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Questions and Answers

Which amino acid is the precursor for thyroid hormones?

  • Serine
  • Methionine
  • Tryptophan
  • Tyrosine (correct)
  • Which of the following is a derivative of tryptophan?

  • Cysteine
  • Serotonin (correct)
  • Creatine
  • Urea
  • Arginine can be synthesized by micro-organisms from which amino acid?

  • Methionine
  • Glutamate (correct)
  • Serine
  • Tyrosine
  • What role does methionine play in biological processes?

    <p>Methyl donor (B)</p> Signup and view all the answers

    Which amino acid is involved in the synthesis of niacin?

    <p>Tryptophan (B)</p> Signup and view all the answers

    What is one of the functions of glutamic acid?

    <p>Synthesis of glutamine (D)</p> Signup and view all the answers

    Which of the following is NOT a product of serine metabolism?

    <p>Creatine (C)</p> Signup and view all the answers

    What is the significance of S-adenosyl methionine (SAM) in biological pathways?

    <p>Serves as a methyl donor (C)</p> Signup and view all the answers

    What is the role of glycine in collagen synthesis?

    <p>It is found in every third position (D)</p> Signup and view all the answers

    Which compound is formed by the conjugation of glycine and benzoate?

    <p>Hippuric acid (A)</p> Signup and view all the answers

    What is the fate of glycine in heme synthesis?

    <p>It reacts with succinyl CoA (B)</p> Signup and view all the answers

    Which amino acid is essential and contributes to the formation of tyrosine?

    <p>Phenylalanine (B)</p> Signup and view all the answers

    What is the primary function of glycine as a neurotransmitter?

    <p>It acts as an inhibitory transmitter (B)</p> Signup and view all the answers

    Which condition is associated with a deficiency in the conversion of phenylalanine to tyrosine?

    <p>Phenylketonuria (D)</p> Signup and view all the answers

    Which of the following derivatives is synthesized from tyrosine?

    <p>Catecholamines (A)</p> Signup and view all the answers

    Flashcards

    What is Glycine?

    Glycine is a non-essential amino acid that plays a vital role in various metabolic processes. It's classified as glucogenic, meaning it can be converted into glucose for energy.

    How does Glycine contribute to purine bases?

    Glycine is a key component of purine bases, which make up DNA and RNA. Specifically, it contributes to the carbon atoms at positions 4 and 5, as well as nitrogen atom 7.

    What is the role of Glycine in glutathione?

    Glutathione is a tripeptide composed of glutamate, cysteine, and glycine. It acts as a powerful antioxidant, protecting cells from damage caused by free radicals.

    What is the role of Glycine in creatine synthesis?

    Creatine is a molecule used by muscles for energy during intense activity. It's synthesized from glycine, arginine, and methionine.

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    What is the role of Glycine in collagen synthesis?

    Glycine is a crucial amino acid for collagen synthesis, a protein that provides structural support to tissues and organs. It's present in every third position in the collagen helix, ensuring its stability.

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    How does Glycine contribute to bile salt formation?

    Glycine is conjugated with primary bile acids, like cholic acid, to form glycocholic acid, a component of bile that aids in fat digestion.

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    How is Glycine related to serine?

    Glycine can be converted into serine, another amino acid, through the action of serine hydroxymethyltransferase.

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    What is the role of Glycine in detoxification?

    Glycine conjugates with toxic benzoate, a byproduct of certain metabolic processes, to form hippuric acid, a non-toxic compound that can be excreted.

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    Serine

    A non-essential amino acid that serves as a precursor for various important biomolecules, including glycine, cysteine, and sphingosine.

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    Methionine

    An essential amino acid involved in the biosynthesis of various critical compounds, including creatine, polyamines, and S-adenosyl methionine (SAM).

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    Glutamic acid

    This non-essential amino acid is synthesized from α-ketoglutarate and plays a crucial role in various metabolic processes.

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    Arginine

    A semi-essential amino acid that can be synthesized from glutamate by microorganisms. It is involved in the production of various important compounds, including creatine, urea, and nitric oxide.

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    Tryptophan

    An essential amino acid that serves as a precursor for various important compounds, including niacin, serotonin, and melatonin.

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    Thyroid hormones

    The amino acid tyrosine is the precursor for the thyroid hormones T3 and T4. These hormones play a vital role in regulating metabolism.

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    Melanin pigment

    Melanin is responsible for pigmentation in various tissues, including the eyes, hair, and skin. It serves as a protective pigment against UV radiation.

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    Phenol, cresol, and tyramine

    These are byproducts of bacterial activity in the large intestine, formed from the breakdown of tyrosine. They can contribute to the foul odor of feces.

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    Study Notes

    Amino Acid Metabolism

    • Glycine:

      • Non-essential, glucogenic amino acid
      • Important in purine base synthesis (carbon atoms 4, 5, and nitrogen atom 7 derived from glycine)
      • Component of glutathione (a tripeptide with glutamate and cysteine), acting as a hydrogen carrier
      • Used in creatine synthesis (combining with arginine and methionine)
      • Used in heme synthesis (reacting with succinyl CoA)
      • Involved in collagen synthesis (present in every third position in the triple helix)
      • Used in bile salt formation (conjugated with primary bile acids, e.g., cholic acid, to form glycocholic acid)
      • Involved in hippuric acid formation (conjugates with toxic benzoate)
      • Acts as an inhibitory neurotransmitter in the spinal cord
      • Involved in glyoxylic acid formation
    • Phenylalanine:

      • Essential, mixed glucogenic and ketogenic amino acid
      • Important in body protein structure
      • Precursor for tyrosine synthesis primarily in the liver
      • Deficiency in the enzymes of the phenylalanine hydroxylase pathway leads to phenylketonuria.
      • The reaction is irreversible
    • Tyrosine:

      • Non-essential amino acid
      • Derived from phenylalanine
      • Mixed glucogenic and ketogenic
      • Important in catecholamine synthesis (precursor to dopamine, noradrenaline, and adrenaline)
      • Precursor to thyroid hormones (T3 and T4)
      • Forms melanin pigment in tissues, particularly in the eye, hair, and skin
      • Involved in the formation of phenol, cresol, and tyramine (putrefactive substances from bacterial action)
    • Tryptophan:

      • Essential amino acid
      • Mixed glucogenic and ketogenic
      • Important in tryptophan derivatives:
        • Biosynthesis of alanine and acetoacetyl CoA
        • Biosynthesis of niacin (vitamin B complex)
        • Biosynthesis of serotonin (5-hydroxytryptamine, a neurotransmitter)
        • Biosynthesis of melatonin (a hormone from the pineal gland)
        • Synthesis of indol and skatole
    • Arginine:

      • Semi-essential, glucogenic amino acid
      • Microorganisms can synthesize it
      • Important in a-ketoglutarate synthesis
      • Involved in creatine synthesis
      • Part of streptomycin synthesis, ornithine conversion to other compounds, urea synthesis, and arginine phosphate synthesis in invertebrates
      • Involved in nitric acid synthesis
    • Serine:

      • Non-essential, glucogenic amino acid
      • Involved in glycine synthesis
      • Part of cysteine and ethanolamine/choline synthesis
      • Involved in sphingosine synthesis
      • Involved in the formation of purine and pyrimidine bases (methyl group source)
      • Involved in phosphoprotein synthesis (e.g., casein)
    • Methionine:

      • Essential, glucogenic amino acid
      • Involved in methyl donor function (as S-adenosylmethionine, SAM)
      • Crucial in creatine, noradrenaline/adrenaline, ethanolamine/choline, carnosine, and anserine synthesis
      • Important in glucose, cysteine, and polyamine synthesis (spermine/spermidine)
    • Glutamic Acid:

      • Non-essential, glucogenic amino acid
      • Synthesized from a-ketoglutarate
      • Involved in a-ketoglutarate synthesis for glucose production
      • Crucial in glutamine, proline, hydroxyproline, ornithine, glutathione, and GABA (inhibitory neurotransmitter) synthesis
    • Aspartic Acid:

      • Non-essential, glucogenic amino acid
      • Synthesized from oxaloacetate through transamination
      • Important in purine and pyrimidine synthesis (source of N1, C4, C5, and C6)
      • Plays a role in urea synthesis
      • Involved in beta-alanine and asparagine synthesis

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    Description

    Test your knowledge on amino acid metabolism, focusing on the roles and functions of glycine and phenylalanine. This quiz covers their synthesis, metabolism, and physiological importance in the human body. Dive into the complex world of biochemistry and enhance your understanding.

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