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Questions and Answers
What is the purpose of the urea cycle?
What is the purpose of the urea cycle?
- Synthesis of glucose
- Excretion of nitrogen as urea (correct)
- Transporting amino acids
- Production of ATP
Which molecule serves as a 'vehicle' for the removal of NH2 groups in transamination?
Which molecule serves as a 'vehicle' for the removal of NH2 groups in transamination?
- Citrulline
- Glutamate (correct)
- Aspartate
- Arginine
What is the rate-limiting enzyme in the urea cycle?
What is the rate-limiting enzyme in the urea cycle?
- N-acetylglutamate
- Aminotransferases
- Carbamoyl phosphate synthetase I (CPS-1) (correct)
- Ornithine
Which process involves the excretion of excess bicarbonate (HCO3-)?
Which process involves the excretion of excess bicarbonate (HCO3-)?
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What is the role of ornithine in the urea cycle?
What is the role of ornithine in the urea cycle?
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Which molecule is synthesized during the urea cycle?
Which molecule is synthesized during the urea cycle?
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What is the function of N-acetylglutamate in the urea cycle?
What is the function of N-acetylglutamate in the urea cycle?
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What is the key function of fumarate in the urea cycle?
What is the key function of fumarate in the urea cycle?
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Study Notes
- Amino acid catabolism involves deamination, where nitrogen is a crucial building block, leading to nitrogen intake, excretion, and balance.
- Transamination is a process where the amino group is transferred from one amino acid to an α-keto acid by aminotransferases to form glutamate, acting as a "vehicle" for the removal of the NH2-group.
- Oxidative deamination is another biosynthetic process involving the conversion of glutamate to α-ketoglutarate, leading to the removal of NH2 through the citric acid cycle.
- Urea cycle in the liver plays a crucial role in excreting nitrogen as urea, involving various steps such as carbamoyl phosphate synthesis, ornithine metabolism, and the synthesis of arginine and fumarate.
- The purpose of the urea cycle includes the excretion of nitrogen as urea, elimination of excess bicarbonate, synthesis of arginine, and production of fumarate.
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