11 Questions
What is considered the best treatment for angioedema caused by Bradykinin-mediated mechanism?
Purified C1-INH
What is the main goal of prophylactic treatment for angioedema?
Prevent bradykinin generation
In a severe acute attack of angioedema, which of the following may be life-saving if performed early?
Tracheal intubation
Which of the following is NOT likely to be effective in treating Bradykinin-mediated angioedema?
Epinephrine
What does FFP provide that may exacerbate Hereditary Angioedema (HAE)?
Kininase II which is ACE
What is the main characteristic of angioedema?
Swelling of deep dermis, subcutaneous, or submucosal tissue
What is the typical peak level timing of serum or plasma tryptase during an angioedema event?
60-90 minutes after onset
In terms of prophylactic treatment, what is the role of corticosteroids in managing angioedema?
No evidence to support routine use except with severe bronchospasm in asthmatics
What is the main mechanism of action of ACE inhibitors that contributes to angioedema in susceptible individuals?
Enhanced bradykinin levels
Which prophylactic treatment is specifically contraindicated for acquired angioedema type II?
Androgen (danazol)
What is the recommended management prior to airway manipulation in patients experiencing acute angioedema?
Provide 2 units of Fresh Frozen Plasma (FFP)
Test your knowledge on the acute treatment of attacks related to mast cell and bradykinin-mediated reactions. Learn about airway management, use of antihistamines, steroids, and epinephrine in different scenarios.
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