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Altose - BLOOD Chapter 6 Quiz

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Questions and Answers

What is considered the best treatment for angioedema caused by Bradykinin-mediated mechanism?

Kallikrein inhibitors (ecallantide)

Epinephrine

Purified C1-INH (correct)

H1-antagonist

What is the main goal of prophylactic treatment for angioedema?

Prevent histamine release

Prevent bradykinin generation (correct)

Reduce airway swelling

Increase complement levels

In a severe acute attack of angioedema, which of the following may be life-saving if performed early?

Tracheal intubation (correct)

Systemic corticosteroid

Epinephrine (IM/SC)

H1-antagonist

Which of the following is NOT likely to be effective in treating Bradykinin-mediated angioedema?

Epinephrine Signup and view all the answers

What does FFP provide that may exacerbate Hereditary Angioedema (HAE)?

Kininase II which is ACE Signup and view all the answers

What is the main characteristic of angioedema?

Swelling of deep dermis, subcutaneous, or submucosal tissue Signup and view all the answers

What is the typical peak level timing of serum or plasma tryptase during an angioedema event?

60-90 minutes after onset Signup and view all the answers

In terms of prophylactic treatment, what is the role of corticosteroids in managing angioedema?

No evidence to support routine use except with severe bronchospasm in asthmatics Signup and view all the answers

What is the main mechanism of action of ACE inhibitors that contributes to angioedema in susceptible individuals?

Enhanced bradykinin levels Signup and view all the answers

Which prophylactic treatment is specifically contraindicated for acquired angioedema type II?

Androgen (danazol) Signup and view all the answers

What is the recommended management prior to airway manipulation in patients experiencing acute angioedema?

Provide 2 units of Fresh Frozen Plasma (FFP) Signup and view all the answers