Altose - BLOOD Chapter 6 Quiz
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Questions and Answers

What is considered the best treatment for angioedema caused by Bradykinin-mediated mechanism?

  • Kallikrein inhibitors (ecallantide)
  • Epinephrine
  • Purified C1-INH (correct)
  • H1-antagonist

What is the main goal of prophylactic treatment for angioedema?

  • Prevent histamine release
  • Prevent bradykinin generation (correct)
  • Reduce airway swelling
  • Increase complement levels

In a severe acute attack of angioedema, which of the following may be life-saving if performed early?

  • Tracheal intubation (correct)
  • Systemic corticosteroid
  • Epinephrine (IM/SC)
  • H1-antagonist

Which of the following is NOT likely to be effective in treating Bradykinin-mediated angioedema?

<p>Epinephrine (C)</p> Signup and view all the answers

What does FFP provide that may exacerbate Hereditary Angioedema (HAE)?

<p>Kininase II which is ACE (B)</p> Signup and view all the answers

What is the main characteristic of angioedema?

<p>Swelling of deep dermis, subcutaneous, or submucosal tissue (C)</p> Signup and view all the answers

What is the typical peak level timing of serum or plasma tryptase during an angioedema event?

<p>60-90 minutes after onset (C)</p> Signup and view all the answers

In terms of prophylactic treatment, what is the role of corticosteroids in managing angioedema?

<p>No evidence to support routine use except with severe bronchospasm in asthmatics (B)</p> Signup and view all the answers

What is the main mechanism of action of ACE inhibitors that contributes to angioedema in susceptible individuals?

<p>Enhanced bradykinin levels (B)</p> Signup and view all the answers

Which prophylactic treatment is specifically contraindicated for acquired angioedema type II?

<p>Androgen (danazol) (B)</p> Signup and view all the answers

What is the recommended management prior to airway manipulation in patients experiencing acute angioedema?

<p>Provide 2 units of Fresh Frozen Plasma (FFP) (C)</p> Signup and view all the answers

Flashcards

Treatment for Bradykinin-mediated Angioedema

Purified C1-INH is considered the best treatment for angioedema caused by Bradykinin-mediated mechanism.

Prophylactic Angioedema Treatment Goal

The main goal of prophylactic treatment for angioedema is to prevent bradykinin generation.

Life-Saving Intervention in Angioedema

In a severe acute attack of angioedema, early tracheal intubation can be life-saving.

Ineffective Treatment for Bradykinin-Mediated Angioedema

Epinephrine is not likely to be effective in treating Bradykinin-mediated angioedema.

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FFP and Hereditary Angioedema

FFP contains Kininase II (ACE), which can exacerbate Hereditary Angioedema (HAE).

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Characteristic of Angioedema

Angioedema is characterized by swelling of deep dermal, subcutaneous, or submucosal tissues.

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Tryptase Peak Timing in Angioedema

The typical peak level timing of serum or plasma tryptase during an angioedema event is 60-90 minutes after onset.

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Corticosteroids in Angioedema Management

Corticosteroids have no proven benefit for routine use in managing angioedema, except for severe bronchospasm in asthmatics.

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ACE Inhibitors and Angioedema

ACE inhibitors increase bradykinin levels, thereby contributing to angioedema in susceptible individuals.

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Contraindicated Prophylaxis for Acquired Angioedema Type II

Androgen (danazol) is specifically contraindicated for acquired angioedema type II.

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Management Before Airway Manipulation in Angioedema

Providing 2 units of Fresh Frozen Plasma (FFP) is recommended before airway manipulation in patients experiencing acute angioedema.

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